Zobrazeno 1 - 10
of 4 057
pro vyhledávání: '"Zachary B"'
Autor:
Rachel (Rae) J. House, Molly T. Soper-Hopper, Michael P. Vincent, Abigail E. Ellis, Colt D. Capan, Zachary B. Madaj, Emily Wolfrum, Christine N. Isaguirre, Carlos D. Castello, Amy B. Johnson, Martha L. Escobar Galvis, Kelsey S. Williams, Hyoungjoo Lee, Ryan D. Sheldon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Metabolite extraction is the critical first-step in metabolomics experiments, where it is generally regarded to inactivate and remove proteins. Here, arising from efforts to improve extraction conditions for polar metabolomics, we discover a
Externí odkaz:
https://doaj.org/article/3c2a5db689674347bf92e9f80980aebe
Autor:
Anand V Sastry, Yuan Yuan, Saugat Poudel, Kevin Rychel, Reo Yoo, Cameron R Lamoureux, Gaoyuan Li, Joshua T Burrows, Siddharth Chauhan, Zachary B Haiman, Tahani Al Bulushi, Yara Seif, Bernhard O Palsson, Daniel C Zielinski
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 10, p e1012546 (2024)
Public gene expression databases are a rapidly expanding resource of organism responses to diverse perturbations, presenting both an opportunity and a challenge for bioinformatics workflows to extract actionable knowledge of transcription regulatory
Externí odkaz:
https://doaj.org/article/012b0c0d41224b3b907edb195e4abdcc
Autor:
Kate J. Dixon, Kristin M. Snyder, Melissa Khaw, Robert Hullsiek, Zachary B. Davis, Anders W. Matson, Soheila Shirinbak, Bryan Hancock, Ryan Bjordahl, Martin Hosking, Jeffrey S. Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionNK cells can mediate tumor cell killing by natural cytotoxicity and by antibody-dependent cell-mediated cytotoxicity (ADCC), an anti-tumor mechanism mediated through the IgG Fc receptor CD16A (FcγRIIIA). CD16A polymorphisms conferring in
Externí odkaz:
https://doaj.org/article/25f0bc6b630e4c64ae1fcc8be73d5e42
Autor:
Matthew G. Romei, Brandon Leonard, Zachary B. Katz, Daniel Le, Yanli Yang, Eric S. Day, Christopher W. Koo, Preeti Sharma, Jack Bevers III, Ingrid Kim, Huiguang Dai, Farzam Farahi, May Lin, Andrey S. Shaw, Gerald Nakamura, Jonathan T. Sockolosky, Greg A. Lazar
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The ability to leverage antibodies to agonize disease relevant biological pathways has tremendous potential for clinical investigation. Yet while antibodies have been successful as antagonists, immune mediators, and targeting agents, they ar
Externí odkaz:
https://doaj.org/article/17d263c9cfc746cea0b227c5efde646d
Autor:
Zachary B Madaj, Michael S. Dahabieh, Vijayvardhan Kamalumpundi, Brejnev Muhire, J. Pettinga, Rebecca A. Siwicki, Abigail E. Ellis, Christine Isaguirre, Martha L. Escobar Galvis, Lisa DeCamp, Russell G. Jones, Scott A. Givan, Marie Adams, Ryan D. Sheldon
Publikováno v:
RNA Biology, Vol 20, Iss 1, Pp 186-197 (2023)
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA extraction for multi-‘omics readout. Using pulverized frozen livers of mice injected with lymphocytic choriomeningitis virus (LCMV) or vehicle (Veh), we isolate
Externí odkaz:
https://doaj.org/article/04874c3865a64c46a4a4eabd9d1a05ee
Publikováno v:
PLoS Genetics, Vol 20, Iss 3, p e1011174 (2024)
A striking paradox is that genes with conserved protein sequence, function and expression pattern over deep time often exhibit extremely divergent cis-regulatory sequences. It remains unclear how such drastic cis-regulatory evolution across species a
Externí odkaz:
https://doaj.org/article/9b7bbe7ae2254769bb29aa955f5949bf
Autor:
Macauley Smith Breault, Pierre Sacré, Zachary B. Fitzgerald, John T. Gale, Kathleen E. Cullen, Jorge A. González-Martínez, Sridevi V. Sarma
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Humans’ ability to adapt and learn relies on reflecting on past performance. These experiences form latent representations called internal states that induce movement variability that improves how we interact with our environment. Our stud
Externí odkaz:
https://doaj.org/article/3f6da8aae07047e591f43338a1b15e52
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1346 (2024)
Kilohertz high-frequency spinal cord stimulation (kHF-SCS) is a rapidly advancing neuromodulatory technique in the clinical management of chronic pain. However, the precise cellular mechanisms underlying kHF-SCS-induced paresthesia-free pain relief,
Externí odkaz:
https://doaj.org/article/c590a15e4d4642ed931e4856080aaec1
Autor:
Cassandra R. Diegel, Ina Kramer, Charles Moes, Gabrielle E. Foxa, Mitchell J. McDonald, Zachary B. Madaj, Sabine Guth, Jun Liu, Jennifer L. Harris, Michaela Kneissel, Bart O. Williams
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signaling components, which increase the activity of the pathway in the skeleton, cause high bone mass in human subjects and
Externí odkaz:
https://doaj.org/article/61eebd1859c547e987869a53f524eaf5
Publikováno v:
mSystems, Vol 9, Iss 2 (2024)
ABSTRACT Understanding the dynamics of biological systems in evolving environments is a challenge due to their scale and complexity. Here, we present a computational framework for the timescale decomposition of biochemical reaction networks to distil
Externí odkaz:
https://doaj.org/article/42278b1b5367444ea9b472a346c84c03