Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Zachary A. Rollins"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Pretrained deep learning models self-supervised on large datasets of language, image, and graph representations are often fine-tuned on downstream tasks and have demonstrated remarkable adaptability in a variety of applications including cha
Externí odkaz:
https://doaj.org/article/b6fc068ee5da43d79a37baee6129b5b4
Autor:
Ahmed M. Alhassan, Venktesh S. Shirure, Jean Luo, Bryan B. Nguyen, Zachary A. Rollins, Bhupinder S. Shergill, Xiangdong Zhu, Nicole Baumgarth, Steven C. George
Publikováno v:
Advanced NanoBiomed Research, Vol 4, Iss 6, Pp n/a-n/a (2024)
Assessing B cell affinity to pathogen‐specific antigens prior to or following exposure could facilitate the assessment of immune status. Current standard tools to assess antigen‐specific B cell responses focus on equilibrium binding of the secret
Externí odkaz:
https://doaj.org/article/7c45425654df4ba6af91d65202c169b5
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2124-2133 (2022)
An atomic-scale mechanism of T Cell Receptor (TCR) mechanosensing of peptides in the binding groove of the peptide-major histocompatibility complex (pMHC) may inform the design of novel TCRs for immunotherapies. Using steered molecular dynamics simul
Externí odkaz:
https://doaj.org/article/dae7e6526e144db8a31ffe22e90ed66a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3473-3481 (2022)
The rational design of T Cell Receptors (TCRs) for immunotherapy has stagnated due to a limited understanding of the dynamic physiochemical features of the TCR that elicit an immunogenic response. The physiochemical features of the TCR-peptide major
Externí odkaz:
https://doaj.org/article/5afaa13783d7465cba24ecd3c1dd7445
T Cell Receptor (TCR) recognition of a peptide-major histocompatibility complex (pMHC) is a crucial component of the adaptive immune response. The identification of therapeutically relevant TCR-pMHC pairs is a significant bottleneck in the implementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::202e870d2a7cee989d0a8d192e11a8a8
https://doi.org/10.1101/2022.06.01.494331
https://doi.org/10.1101/2022.06.01.494331
An atomic-scale mechanism describing the role of mechanosensing in T Cell Receptor (TCR) recognition of peptides in the binding groove of the peptide-major histocompatibility complex (pMHC) may inform the design of novel TCRs for immunotherapies. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a35abcb93d52ba9332c004817fdd3de
https://doi.org/10.1101/2021.10.27.466112
https://doi.org/10.1101/2021.10.27.466112
Autor:
Venktesh S. Shirure, Daniel C. Link, Drew Elizabeth Glaser, Natalie R. Ng, Leif S. Anderson, Matthew B. Curtis, Peter A. Sariano, Zachary A. Rollins, Aravind Anand, Steven C. George, Alyssa M. Deely, Jeremy M. Lowen, Bhupinder S. Shergill, Katherine N. Weilbaecher
Publikováno v:
Biomaterials. 280:121245
Animal models of bone marrow have limited spatial and temporal resolution to observe biological events (intravasation and cellular egress) and are inadequate to dissect dynamic events at the niche level (100 microns). Utilizing microfluidic and stem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0178242243ccbfa8650f14d654f9f7d
https://doi.org/10.1016/j.biomaterials.2021.121245
https://doi.org/10.1016/j.biomaterials.2021.121245