Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Zachary A Hing"'
Autor:
Nathan C Edwards, Zachary A Hing, Avital Perry, Adam Blaisdell, David B Kopelman, Robert Fathke, William Plum, Jordan Newell, Courtni E Allen, Geetha S, Aaron Shapiro, Chinyere Okunji, Idit Kosti, Noam Shomron, Vahan Grigoryan, Teresa M Przytycka, Zuben E Sauna, Raheleh Salari, Yael Mandel-Gutfreund, Anton A Komar, Chava Kimchi-Sarfaty
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38864 (2012)
Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these "silent"
Externí odkaz:
https://doaj.org/article/1425d58426564ce68f4b13d5944197e4
Autor:
Zachary A. Hing, Janek S. Walker, Ethan C. Whipp, Lindsey Brinton, Matthew Cannon, Pu Zhang, Steven Sher, Casey B. Cempre, Fiona Brown, Porsha L. Smith, Claudio Agostinelli, Stefano A. Pileri, Jordan N. Skinner, Katie Williams, Hannah Phillips, Jami Shaffer, Larry P. Beaver, Alexander Pan, Kyle Shin, Charles T. Gregory, Gulcin H. Ozer, Selen A. Yilmaz, Bonnie K. Harrington, Amy M. Lehman, Lianbo Yu, Vincenzo Coppola, Pearlly Yan, Peggy Scherle, Min Wang, Philip Pitis, Chaoyi Xu, Kris Vaddi, Selina Chen-Kiang, Jennifer Woyach, James S. Blachly, Lapo Alinari, Yiping Yang, John C. Byrd, Robert A. Baiocchi, Bradley W. Blaser, Rosa Lapalombella
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Richter’s Transformation is a treatment-resistant and fatal progression from Chronic Lymphocytic Leukemia (CLL) to an aggressive lymphoma. Here, the authors show that PRMT5 is upregulated months prior to and after transformation, PRMT5 overexpressi
Externí odkaz:
https://doaj.org/article/69b4b26dffde485788921c4c7e1fc14a
Autor:
Janek S. Walker, Zachary A. Hing, Steven Sher, James Cronin, Katie Williams, Bonnie Harrington, Jordan N. Skinner, Casey B. Cempre, Charles T. Gregory, Alexander Pan, Max Yano, Larry P. Beaver, Brandi R. Walker, Jadwiga M. Labanowska, Nyla A. Heerema, Krzysztof Mrózek, Jennifer A. Woyach, Amy S. Ruppert, Amy Lehman, Hatice Gulcin Ozer, Vincenzo Coppola, Pearlly Yan, John C. Byrd, James S. Blachly, Rosa Lapalombella
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Some genes that are part of balanced translocations are reported as drivers for tumourigenesis. Here, the authors report a translocation involving MTCP1 in chronic lymphocytic leukemia and show that MTCP1 overexpression leads to the disease in a muri
Externí odkaz:
https://doaj.org/article/810bfd0089064a989b380ab83b7f18b0
Autor:
Janek S. Walker, Zachary A. Hing, Bonnie Harrington, Jordan Baumhardt, Hatice Gulcin Ozer, Amy Lehman, Brian Giacopelli, Larry Beaver, Katie Williams, Jordan N. Skinner, Casey B. Cempre, Qingxiang Sun, Sharon Shacham, Benjamin R. Stromberg, Matthew K. Summers, Lynne V. Abruzzo, Laura Rassenti, Thomas J. Kipps, Sameer Parikh, Neil E. Kay, Kerry A. Rogers, Jennifer A. Woyach, Vincenzo Coppola, Yuh Min Chook, Christopher Oakes, John C. Byrd, Rosa Lapalombella
Publikováno v:
Journal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-21 (2021)
Abstract Background Exportin 1 (XPO1/CRM1) is a key mediator of nuclear export with relevance to multiple cancers, including chronic lymphocytic leukemia (CLL). Whole exome sequencing has identified hot-spot somatic XPO1 point mutations which we foun
Externí odkaz:
https://doaj.org/article/5d10b5b0f27b4de5a2529f4fedcb0538
Autor:
Rosa Lapalombella, John C. Byrd, Gideon Bollag, Ewy A. Mathé, Chao Zhang, Prabha Ibrahim, Gaston Habets, Bernice Matusow, Marika Nespi, Hamid Rezaei, Laura Sanftner, Jason Walters, Christina Tantoy, Adhirai Marimuthu, Todd Ewing, Ken Dong, Garson Tsang, Heidi Carias, Rafe Shellooe, Paul Severson, Songyuan Shi, Wayne Spevak, Ying Zhang, Yan Ma, Jiazhong Zhang, Lianbo Yu, Amy M. Lehman, Deepa Sampath, Jennifer A. Woyach, David M. Lucas, Virginia M. Goettl, Larry Beaver, Matthew Cannon, Elizabeth Baskin, Lindsey Brinton, Robert A. Baiocchi, Lapo Alinari, Tzung-Huei Lai, Katie Williams, Nicole R. Grieselhuber, Shaneice Mitchell, Bonnie Harrington, James S. Blachly, Zachary A. Hing, Ben Powell, Dalia El-Gamal, Hatice Gulcin Ozer
Supplementary Figures S1-S7 with captions and Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7533dd2eb9678807fc10bb97d5617e
https://doi.org/10.1158/2159-8290.22532987
https://doi.org/10.1158/2159-8290.22532987
Autor:
Rosa Lapalombella, John C. Byrd, Gideon Bollag, Ewy A. Mathé, Chao Zhang, Prabha Ibrahim, Gaston Habets, Bernice Matusow, Marika Nespi, Hamid Rezaei, Laura Sanftner, Jason Walters, Christina Tantoy, Adhirai Marimuthu, Todd Ewing, Ken Dong, Garson Tsang, Heidi Carias, Rafe Shellooe, Paul Severson, Songyuan Shi, Wayne Spevak, Ying Zhang, Yan Ma, Jiazhong Zhang, Lianbo Yu, Amy M. Lehman, Deepa Sampath, Jennifer A. Woyach, David M. Lucas, Virginia M. Goettl, Larry Beaver, Matthew Cannon, Elizabeth Baskin, Lindsey Brinton, Robert A. Baiocchi, Lapo Alinari, Tzung-Huei Lai, Katie Williams, Nicole R. Grieselhuber, Shaneice Mitchell, Bonnie Harrington, James S. Blachly, Zachary A. Hing, Ben Powell, Dalia El-Gamal, Hatice Gulcin Ozer
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b606648bc10ea30723eacd8e307e1ba
https://doi.org/10.1158/2159-8290.22532984.v1
https://doi.org/10.1158/2159-8290.22532984.v1
Autor:
Jennifer A. Woyach, Rosa Lapalombella, John C. Byrd, Pearlly Yan, Danielle K. White, Ronni Wasmuth, Lisa L. Smith, Deepa Sampath, Rose Mantel, Parviz Kanga, Zachary A. Hing, Virginia M. Goettl, Ralf Bundschuh, Justin Breitbach, Lianbo Yu, Alexander Pan, Bonnie K. Harrington, Kerry A. Rogers, Fabienne Lucas
Purpose:Aberrant Myc expression is a major factor in the pathogenesis of aggressive lymphoma, and these lymphomas, while clinically heterogeneous, often are resistant to currently available treatments and have poor survival. Myc expression can also b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5018b4badb203541096ba4b3eaff1e04
https://doi.org/10.1158/1078-0432.c.6528003.v1
https://doi.org/10.1158/1078-0432.c.6528003.v1
Autor:
Jennifer A. Woyach, Rosa Lapalombella, John C. Byrd, Pearlly Yan, Danielle K. White, Ronni Wasmuth, Lisa L. Smith, Deepa Sampath, Rose Mantel, Parviz Kanga, Zachary A. Hing, Virginia M. Goettl, Ralf Bundschuh, Justin Breitbach, Lianbo Yu, Alexander Pan, Bonnie K. Harrington, Kerry A. Rogers, Fabienne Lucas
Supplemental Table 4: Abundance information of top 20 CDR3 sequences and top 10 heavy chains and top 10 light chains (see supplemental Excel file) Supplemental Table 5: DESeq2 normalized counts, log2-fold change, and p-values and adjusted p-values fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d043b9370501e6f6f0432db79a7c14
https://doi.org/10.1158/1078-0432.22471764
https://doi.org/10.1158/1078-0432.22471764
Autor:
Jennifer A. Woyach, Rosa Lapalombella, John C. Byrd, Pearlly Yan, Danielle K. White, Ronni Wasmuth, Lisa L. Smith, Deepa Sampath, Rose Mantel, Parviz Kanga, Zachary A. Hing, Virginia M. Goettl, Ralf Bundschuh, Justin Breitbach, Lianbo Yu, Alexander Pan, Bonnie K. Harrington, Kerry A. Rogers, Fabienne Lucas
Supplemental Figure 1: Commonly used murine cell surface markers of B-cell development Supplemental Figure 2: Multicolor flow cytometry gating strategy and representative flow plots from a WT spleen sample Supplemental Figure 3: Histopathological ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5554d034a94e47c52c61b5b513009ac
https://doi.org/10.1158/1078-0432.22471767.v1
https://doi.org/10.1158/1078-0432.22471767.v1
Autor:
Amy S. Ruppert, Larry Beaver, Bonnie K. Harrington, Janek S. Walker, Brandi R. Walker, Katie Williams, James Cronin, Zachary A. Hing, Alexander Pan, Jordan N. Skinner, Jennifer A. Woyach, Nyla A. Heerema, Steven Sher, Amy Lehman, Charles Thomas Gregory, Vincenzo Coppola, Rosa Lapalombella, Krzysztof Mrózek, Max Yano, Pearlly S. Yan, Hatice Gulcin Ozer, James S. Blachly, Jadwiga Labanowska, John C. Byrd, Casey Cempre
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Rare, recurrent balanced translocations occur in a variety of cancers but are often not functionally interrogated. Balanced translocations with the immunoglobulin heavy chain locus (IGH; 14q32) in chronic lymphocytic leukemia (CLL) are infrequent but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4020fc2f6408fa397a551b9d41261e40
https://doaj.org/article/810bfd0089064a989b380ab83b7f18b0
https://doaj.org/article/810bfd0089064a989b380ab83b7f18b0