Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Zachary, Benet"'
Autor:
Julia Schanin, Wouter Korver, Emily C. Brock, John Leung, Zachary Benet, Thuy Luu, Katherine Chang, Alan Xu, Naomi De Freitas, Kenneth Luehrsen, Michael A. Brehm, Alan Wong, Bradford A. Youngblood
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.
Externí odkaz:
https://doaj.org/article/8555549fd31544c7aa8404b25f5252f9
Autor:
Wouter Korver, Alan Wong, Simon Gebremeskel, Gian Luca Negri, Julia Schanin, Katherine Chang, John Leung, Zachary Benet, Thuy Luu, Emily C. Brock, Kenneth Luehrsen, Alan Xu, Bradford A. Youngblood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immunomodulation of mast cell (MC) activity is warranted in allergic and inflammatory diseases where MCs have a central role in pathogenesis. Targeting Siglec-8, an inhibitory receptor on MCs and eosinophils, has shown promising activity in preclinic
Externí odkaz:
https://doaj.org/article/fc996b1aedce4815b6a0eb6f4573d07f
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108733- (2021)
Summary: Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest.
Externí odkaz:
https://doaj.org/article/4591b4b0d6e846498a6cfa03566414a1
Autor:
Tonya Aaron, Ethan Laudermilch, Zachary Benet, Luis Jose Ovando, Kartik Chandran, David Fooksman
Publikováno v:
The Journal of Immunology. 210:595-608
Both infection and autoimmune disease can disrupt pre-existing Ab titers leading to diminished serological memory, yet the underlying mechanisms are not well understood. In this article, we report that TNF-α, an inflammatory cytokine, is a master re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c93bbb644dba6357cde57287c1472a55
https://doi.org/10.4049/jimmunol.2200053
https://doi.org/10.4049/jimmunol.2200053
Publikováno v:
British Journal of Dermatology. 188
Atopic dermatitis (AD) is a debilitating type 2 inflammatory disease of the skin characterized by pruritus. Mast cells (MCs) and eosinophils (eos) are elevated in AD tissue. Siglecs are inhibitory receptors found on immune cells, with Siglec-8 select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb20b667199a0eeb2650bf1a5afeb7e6
https://doi.org/10.1093/bjd/ljac140.003
https://doi.org/10.1093/bjd/ljac140.003
Autor:
Zachary Benet, Thuy Luu, Emily Brock, Robert Sanchez, Lisa McEwen, Krysta Coyle, Katherine Chang, John Leung, Julia Schanin, Bradford Youngblood
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:AB168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16e55d4f75cb21b5074af6bfdce83bdb
https://doi.org/10.1016/j.jaci.2022.12.526
https://doi.org/10.1016/j.jaci.2022.12.526
Autor:
Marie, Boutet, Zachary, Benet, Erik, Guillen, Caroline, Koch, Saidi, M'Homa Soudja, Fabien, Delahaye, David, Fooksman, Grégoire, Lauvau
Publikováno v:
Science advances. 7(36)
While cognate antigen drives clonal expansion of memory CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe3df70a5122f56dd1c11d3f04fd8215
https://pubmed.ncbi.nlm.nih.gov/34516896
https://pubmed.ncbi.nlm.nih.gov/34516896
Autor:
Marie Boutet, Erik Guillen, David R. Fooksman, Grégoire Lauvau, Fabien Delahaye, Zachary Benet, Saidi M.Homa Soudja, Caroline Koch
Publikováno v:
Science Advances. 7
While cognate antigen drives clonal expansion of memory CD8+ T (CD8+ TM) cells to achieve sterilizing immunity in immunized hosts, not much is known on how cognate antigen contributes to early prot...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a07d06b7c4d0c2c6d8f577751aa973a9
https://doi.org/10.1126/sciadv.abf9975
https://doi.org/10.1126/sciadv.abf9975
Autor:
Grégoire Lauvau, Saidi M.Homa Soudja, Caroline Koch, Fabien Delahaye, Erik Guillen, Marie Boutet, Zachary Benet, David R. Fooksman
SummaryWhile cognate antigen drives clonal expansion of memory CD8+ T cells to achieve sterilizing immunity in immunized hosts, not much is known on how cognate antigen contributes to early mechanisms of protection before clonal expansion occurs. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22dbcbb194be25b6f2a7b7643759321
https://doi.org/10.1101/2021.03.01.433468
https://doi.org/10.1101/2021.03.01.433468
Publikováno v:
Cell Reports, Vol 34, Iss 6, Pp 108733-(2021)
Cell reports
Cell reports
SUMMARY Using intravital imaging, we report that bone marrow (BM) plasma cells (PCs) are motile. BM PCs exhibit a unique migration pattern, characterized by intermittent periods of high motility and longer stretches of confined migration or arrest. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c6af8f1052d98e81736a832ffa449d
http://www.sciencedirect.com/science/article/pii/S2211124721000462
http://www.sciencedirect.com/science/article/pii/S2211124721000462