Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Zach N. Adelman"'
Autor:
Keun Chae, Bryan Contreras, Joseph S. Romanowski, Chanell Dawson, Kevin M. Myles, Zach N. Adelman
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-12 (2024)
Abstract While gene drive strategies have been proposed to aid in the control of mosquito-borne diseases, additional genome engineering technologies may be required to establish a defined end-of-product-life timeline. We previously demonstrated that
Externí odkaz:
https://doaj.org/article/bc97b98283914ad4987d0d0f92111d5f
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background This study explores the impact of disrupting the circadian clock through a Cycle gene knockout (KO) on the transcriptome of Aedes aegypti mosquitoes. The investigation aims to uncover the resulting alterations in gene expression p
Externí odkaz:
https://doaj.org/article/280f6cc14946489e9d83d22495e07f65
Autor:
Michelle A. E. Anderson, Philip T. Leftwich, Ray Wilson, Leonela Z. Carabajal Paladino, Sanjay Basu, Sara Rooney, Zach N. Adelman, Luke Alphey
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Molecular tools for modulating transgene expression in Aedes aegypti are few. Here we demonstrate that adjustments to the AePUb promoter length can alter expression levels of two reporter proteins in Ae. aegypti cell culture and in mosquitoe
Externí odkaz:
https://doaj.org/article/e4baf41570014ae0bae6694211dc1f2d
Autor:
Vivian Petersen, Micael Santana, Maria Karina-Costa, Julia Jardim Nachbar, Ines Martin-Martin, Zach N. Adelman, Bianca C. Burini
Publikováno v:
Insects, Vol 15, Iss 8, p 600 (2024)
More than 3550 species of mosquitoes are known worldwide, and only a fraction is involved in the transmission of arboviruses. Mosquitoes in sylvatic and semi-sylvatic habitats may rapidly adapt to urban parks and metropolitan environments, increasing
Externí odkaz:
https://doaj.org/article/e2726cb7bf7e443ba4fe2134b465ae39
Autor:
Ines Martin-Martin, Bianca Burini Kojin, Azadeh Aryan, Adeline E. Williams, Alvaro Molina-Cruz, Paola Carolina Valenzuela-Leon, Gaurav Shrivastava, Karina Botello, Mahnaz Minai, Zach N. Adelman, Eric Calvo
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMosquito saliva facilitates blood meal acquisition through pharmacologically active compounds that prevent host hemostasis and immune responses. Here, we generated two knockout (KO) mosquito lines by CRISPR/Cas9 to functionally characterize D
Externí odkaz:
https://doaj.org/article/3cccb39e9ce743b2811975d69e58eeef
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-11 (2022)
Abstract Programmable gene editing systems such as CRISPR-Cas have made mosquito genome engineering more practical and accessible, catalyzing the development of cutting-edge genetic methods of disease vector control. This progress, however, has been
Externí odkaz:
https://doaj.org/article/b60bf54a47534772a1c9a236188ae271
Autor:
Keun Chae, Justin M. Overcash, Chanell Dawson, Collin Valentin, Hitoshi Tsujimoto, Kevin M. Myles, Zach N. Adelman
Publikováno v:
Current Research in Biotechnology, Vol 5, Iss , Pp 100133- (2023)
To maintain genome stability, eukaryotic cells orchestrate DNA repair pathways to process DNA double-strand breaks (DSBs) that result from diverse developmental or environmental stimuli. Bias in the selection of DSB repair pathways, either non-homolo
Externí odkaz:
https://doaj.org/article/2341a7d44b334f06ab0f260f7b6aea3e
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Genetics-based pest management processes, including the sterile insect technique, are an effective method for the control of some pest insects. However, current SIT methods are not directly transferable to many important pest insect species
Externí odkaz:
https://doaj.org/article/5e5bb594c78b4bca85f0e81f86ee920a
Autor:
Madhav Erraguntla, Darpit Dave, Josef Zapletal, Kevin Myles, Zach N. Adelman, Tyler D. Pohlenz, Mark Lawley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Mosquitoes transmit several infectious diseases that pose significant threat to human health. Temperature along with other environmental factors at breeding and resting locations play a role in the organismal development and abundance of mos
Externí odkaz:
https://doaj.org/article/e6e8e1ad67f545708431fc6fc9bab581
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
CRISPR-based autonomous homing gene drives are a potentially transformative technology with the power to reduce the prevalence of, or even eliminate, vector-borne diseases, agricultural pests, and invasive species. However, there are a number of regu
Externí odkaz:
https://doaj.org/article/7cefbcb30f034e9a9369e63bbf2d5e71