Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Zach Madaj"'
Autor:
Noah Lubben, Julia K. Brynildsen, Connor M. Webb, Howard L. Li, Cheryl E. G. Leyns, Lakshmi Changolkar, Bin Zhang, Emily S. Meymand, Mia O’Reilly, Zach Madaj, Daniella DeWeerd, Matthew J. Fell, Virginia M. Y. Lee, Dani S. Bassett, Michael X. Henderson
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-20 (2024)
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). These mutations elevate the LRRK2 kinase activity, making LRRK2 kinase inhibitors an attractive therapeutic. LRRK2
Externí odkaz:
https://doaj.org/article/1f84f0e37fc14d51a4c531d8dca9e20e
Autor:
Qiong Sha, Zach Madaj, Sarah Keaton, Martha L Escobar Galvis, LeAnn Smart, Stanislaw Krzyzanowski, Asgerally T. Fazleabas, Richard Leach, Teodor T. Postolache, Eric D. Achtyes, Lena Brundin
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Depression during and after pregnancy affects up to 20% of pregnant women, but the biological underpinnings remain incompletely understood. As pregnancy progresses, the immune system changes to facilitate fetal development, leading to distin
Externí odkaz:
https://doaj.org/article/5361560700f1439a904d8c6cdd06329d
Autor:
Elizabeth Kenyon, Jennifer J. Westerhuis, Maximilian Volk, Jeremy Hix, Shatadru Chakravarty, Ethan Claucherty, Erin Zaluzec, Lisa Ramsey, Zach Madaj, Galen Hostetter, Bryn Eagleson, Erik Shapiro, Anna Moore, Lorenzo F. Sempere
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Abstract Background Prophylactic mastectomy is the most effective intervention to prevent breast cancer. However, this major surgery has life-changing consequences at the physical, emotional, psychological, and social levels. Therefore, only high-ris
Externí odkaz:
https://doaj.org/article/b1ea0341654f4fce87796e107f278d4b
Autor:
Matti Kiupel, Ian Beddows, Zach Madaj, David J. Monsma, Jennifer J. Westerhuis, Lorenzo F. Sempere, Galen Hostetter, Jose R. Conejo-Garcia, Josh Schipper
Publikováno v:
International Journal of Cancer. 147:2265-2278
The microenvironment of pancreatic cancer adenocarcinoma (PDAC) is highly desmoplastic with distinct tumor-restraining and tumor-promoting fibroblast subpopulations. Re-education rather than indiscriminate elimination of these fibroblasts has emerged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8767ef399720b4018cadf656a86f114d
https://doi.org/10.1002/ijc.33041
https://doi.org/10.1002/ijc.33041
Autor:
Erik M. Shapiro, Maximilian Volk, Zach Madaj, Bryn Eagleson, Elizabeth Kenyon, Anna Moore, Jennifer J. Westerhuis, Lorenzo F. Sempere, Lisa Ramsey, Erin Zaluzec, Galen Hostetter, Jeremy M. L. Hix, Ethan Claucherty, Shatadru Chakravarty
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Breast Cancer Research, Vol 21, Iss 1, Pp 1-14 (2019)
Background Prophylactic mastectomy is the most effective intervention to prevent breast cancer. However, this major surgery has life-changing consequences at the physical, emotional, psychological, and social levels. Therefore, only high-risk individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48f09d489fca0b5b65c84bce305c059
https://doi.org/10.1186/s13058-019-1217-x
https://doi.org/10.1186/s13058-019-1217-x
Autor:
Zhendong A. Zhong, Zach Madaj, Jingchen Cao, Xiangqi Meng, Sourik S. Ganguly, Paul G. Daft, Bart O. Williams, Xiaohong Li, Alexandra Vander Ark, Austin Meadows
Publikováno v:
Cancers
Volume 10
Issue 12
Cancers, Vol 10, Iss 12, p 463 (2018)
Volume 10
Issue 12
Cancers, Vol 10, Iss 12, p 463 (2018)
The role of myeloid cell-specific TGF-&beta
signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF
signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa38fd8d476654431c98e46f42b123b7
https://doi.org/10.3390/cancers10120463
https://doi.org/10.3390/cancers10120463
Autor:
Guillermo Flores, Patrick J. Grohar, Zach Madaj, Kathleen Sorensen, Susan M. Goosen, Jennifer Jess, Elissa Bogulaslawski
Publikováno v:
Cancer Research. 78:5817-5817
Background: Ewing sarcoma (ES) is the second most common childhood bone tumor that is in need of new molecularly targeted agents. This tumor is driven by the aberrant activity of the EWS-FLI1 transcription factor that both drives proliferation and bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9265ffb625b892b7ba1083521c4e24f7
https://doi.org/10.1158/1538-7445.am2018-5817
https://doi.org/10.1158/1538-7445.am2018-5817
Abstract B14: Targeting the intratumoral heterogeneity of receptor tyrosine kinases in breast cancer
Autor:
Mary E. Winn, Julie L. Boerner, Erik S. Linklater, Zach Madaj, Elizabeth A. Tovar, Hasan Korkaya, Curt J. Essenburg, David Cherba, Carrie R. Graveel
Publikováno v:
Molecular Cancer Research. 14:B14-B14
Breast cancers display a remarkable phenotypic diversity that is exploited to promote both tumor progression and therapeutic resistance. Recent studies in several types of cancer have highlighted the significance of intratumoral heterogeneity on both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::823454dabcef6c2de40995ef2155a1de
https://doi.org/10.1158/1557-3125.advbc15-b14
https://doi.org/10.1158/1557-3125.advbc15-b14
Autor:
Angela Y. Bai, Khursheed Iqbal, Zach Madaj, Mary E. Winn, Charles Warden, Arthur X. Li, Piroska E. Szabó, Diana A. Tran, Gerd P. Pfeifer, Purnima Singh, Xiwei Wu
Publikováno v:
Genome Biology
In a recent paper, we described our efforts in search for evidence supporting epigenetic transgenerational inheritance caused by endocrine disrupter chemicals. One aspect of our study was to compare genome-wide DNA methylation changes in the vinclozo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0123f124785ba2c3c00e4c3f9c64be68