Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Zach Dwyer"'
Autor:
Zach Dwyer, Melany Chaiquin, Jeffrey Landrigan, Kiara Ayoub, Pragya Shail, Julianna Rocha, Christie L. Childers, Kenneth B. Storey, Dana J. Philpott, Hongyu Sun, Shawn Hayley
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Abstract Background Recent work has established that Parkinson’s disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as w
Externí odkaz:
https://doaj.org/article/ae51a5980fbe41598abca705b69ffe6e
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-13 (2019)
Abstract Background Leucine-rich repeat kinase 2 (LRRK2) is a common gene implicated in Parkinson’s disease (PD) and is also thought to be fundamentally involved in numerous immune functions. Thus, we assessed the role of LRRK2 in the context of th
Externí odkaz:
https://doaj.org/article/55f98499bde14386a634403ba984cd5b
Publikováno v:
Allergy, Asthma & Clinical Immunology, Vol 14, Iss 1, Pp 1-11 (2018)
Abstract Background Accumulating evidence suggests that the gut microbiota shapes developmental processes within the immune system. Early life antibiotic use is one factor which may contribute to immune dysfunction and the recent surge in allergies b
Externí odkaz:
https://doaj.org/article/007912737fd04ac7a522bff5e2c7e69c
Autor:
Zach Dwyer, Chris Rudyk, Divya Situt, Sheryl Beauchamp, Jawaria Abdali, Anu Dinesh, Nathalie Legancher, Hongyu Sun, Michael Schlossmacher, Shawn Hayley
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 5, Iss , Pp 100079- (2020)
Background: Substantial data have implicated microglial-driven neuroinflammation in Parkinson’s disease (PD) and environmental toxicants have been long expected as triggers of such inflammatory processes. Of course, these environmental insults act
Externí odkaz:
https://doaj.org/article/fe2942bfab9b48648796cf50eae30ed0
Autor:
Chris Rudyk, Zach Dwyer, Jessica McNeill, Natalina Salmaso, Kyle Farmer, Natalie Prowse, Shawn Hayley
Publikováno v:
Neurobiology of Stress, Vol 11, Iss , Pp - (2019)
The impact of psychological stressors on the progression of motor and non-motor disturbances observed in Parkinson's disease (PD) has received little attention. Given that PD likely results from many different environmental “hits”, we were intere
Externí odkaz:
https://doaj.org/article/1c7af0148bd14233b612fbe4cfdfd446
Publikováno v:
Neurobiology of Stress, Vol 2, Iss C, Pp 85-93 (2015)
A number of epidemiological and experimental studies have implicated the non-selective herbicide, paraquat, in the development of sporadic Parkinson's disease (PD). While preclinical research has focused mainly on elucidating the nigrostriatal effect
Externí odkaz:
https://doaj.org/article/f9e79826087043ff97bc1ed9ae7b3671
Autor:
Chris A. Rudyk, Jessica McNeill, Natalie Prowse, Zach Dwyer, Kyle Farmer, Darcy Litteljohn, Warren Caldwell, Shawn Hayley
Publikováno v:
Frontiers in Aging Neuroscience, Vol 9 (2017)
Little is known of the age-dependent and long-term consequences of low exposure levels of the herbicide and dopaminergic toxicant, paraquat. Thus, we assessed the dose-dependent effects of paraquat using a typical short-term (3 week) exposure procedu
Externí odkaz:
https://doaj.org/article/3a06d64e825a49ebbaa18a3a60bac014
Autor:
Pragya Shail, Katelyn Ventura, Sheryl Beauchamp, Teresa Fortin, Shawn Hayley, Chris Rudyk, Carlos Torres, Zach Dwyer, Kyle Farmer, Kiara Ayoub, Alexa Derksen
Publikováno v:
Neurobiology of Aging. 100:11-21
The primary motor symptoms of Parkinson's disease (PD) result from the degeneration of dopamine-producing neurons of the substantia nigra pars compacta (SNc), and often, the loss is asymmetrical, resulting in unilateral tremor presentation. Notably,
Publikováno v:
NeuroToxicology. 76:153-161
Parkinson's disease (PD) is characterized by profound microglial driven inflammatory processes and the loss of dopamine neurons of the substantia nigra (SNc). Both microglia and dopamine neurons that are affected in the SNc are particularly vulnerabl
Autor:
Zach Dwyer, Jeffrey Landrigan, Julianna Rocha, Shawn Hayley, Kiara Ayoub, Christie L. Childers, Kenneth B. Storey, Melany Chaiquin, Hongyu Sun, Dana J. Philpott, Pragya Shail
Publikováno v:
Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-15 (2021)
Background Recent work has established that Parkinson’s disease (PD) patients have an altered gut microbiome, along with signs of intestinal inflammation. This could help explain the high degree of gastric disturbances in PD patients, as well as po