CSF1R inhibition depletes brain macrophages and reduces brain virus burden in SIV-infected macaques.

Autor: Bohannon DG; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA., Zablocki-Thomas LD; Department of Anatomy, Physiology & Cell Biology, University California, Davis School of Veterinary Medicine, Davis, CA 95616, USA., Leung ES; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA., Dupont JK; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA., Hattler JB; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA., Kowalewska J; Department of Pathology and Anatomy, Eastern Virginia Medical School, Norfolk, VA 23507, USA., Zhao M; Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Luo J; Department of Health Systems and Population Health Sciences, the Tilman J. Fertitta Family College of Medicine, University of Houston, Houston, TX 77204, USA., Salemi M; Department of Epidemiology, University of Florida College of Medicine, Gainesville, FL 32610, USA., Amedee AM; Department of Microbiology, Immunology & Parasitology, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA., Li Q; Nebraska Center for Virology, School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA., Kuroda MJ; Department of Anatomy, Physiology & Cell Biology, University California, Davis School of Veterinary Medicine, Davis, CA 95616, USA., Kim WK; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA.; Division of Microbiology, Tulane National Primate Research Center, Covington, LA, 70433, USA.; Department of Microbiology & Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Publikováno v: Brain : a journal of neurology [Brain] 2024 Sep 03; Vol. 147 (9), pp. 3059-3069.