Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

Autor: Koltun DO; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States. Electronic address: dmitry.koltun@gilead.com., Parkhill EQ; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Kalla R; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Perry TD; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Elzein E; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Li X; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Simonovich SP; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Ziebenhaus C; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Hansen TR; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Marchand B; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Hung WK; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Lagpacan L; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Hung M; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Aoyama RG; Department of Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Murray BP; Department of Drug Metabolism, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Perry JK; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Somoza JR; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Villaseñor AG; Department of Structural Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Pagratis N; Department of Biology, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States., Zablocki JA; Department of Medicinal Chemistry, Gilead Sciences, Inc., 333 Lakeside Dr., Foster City, CA 94404, United States.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Feb 01; Vol. 28 (3), pp. 541-546. Date of Electronic Publication: 2017 Oct 20.

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Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late I Na i), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties.

Autor: Zablocki JA, Elzein E, Li X, Koltun DO, Parkhill EQ, Kobayashi T, Martinez R, Corkey B, Jiang H, Perry T, Kalla R, Notte GT, Saunders O, Graupe M, Lu Y, Venkataramani C, Guerrero J, Perry J, Osier M, Strickley R, Liu G; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Wang WQ; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Hu L; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Li XJ; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., El-Bizri N; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Hirakawa R; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Kahlig K; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Xie C; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Li CH; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Dhalla AK; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Rajamani S; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Mollova N, Soohoo D, Lepist EI, Murray B, Rhodes G, Belardinelli L; Biology, Gilead Sciences Inc. , 7601 Dumbarton Circle, Fremont, California 94555, United States., Desai MC

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Oct 13; Vol. 59 (19), pp. 9005-9017. Date of Electronic Publication: 2016 Oct 03.