Single episode of moderate to severe traumatic brain injury leads to chronic neurological deficits and Alzheimer's-like pathological dementia.

Autor: Vaibhav K; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA. kvaibhav@augusta.edu.; Transdisciplinary Research Initiative in Inflammaging and Brain Aging (TRIBA), Augusta University, Augusta, GA, USA. kvaibhav@augusta.edu., Gulhane M; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Ahluwalia P; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Kumar M; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA., Ahluwalia M; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA.; Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA., Rafiq AM; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA., Amble V; Center for Undergraduate Research Studies, Augusta University, Augusta, GA, USA., Zabala MG; Center for Undergraduate Research Studies, Augusta University, Augusta, GA, USA., Miller JB; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA.; The Graduate School, Augusta University, Augusta, GA, USA., Goldman L; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA., Mondal AK; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Deak F; Department of Neuroscience and Regenerative Medicine, Medical College of Georgia, Augusta University, Augusta, GA, USA., Kolhe R; Department of Pathology, Medical College of Georgia, Augusta University, Augusta, GA, USA., Arbab AS; Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, GA, USA., Vale FL; Brain Injury, Senescence, and Translational Neuroscience Lab, Department of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.

Publikováno v: GeroScience [Geroscience] 2024 Dec; Vol. 46 (6), pp. 5439-5457. Date of Electronic Publication: 2024 May 11.