Zobrazeno 1 - 10
of 366
pro vyhledávání: '"Zaal KOKAIA"'
Autor:
Ninoslav Pandiloski, Vivien Horváth, Ofelia Karlsson, Symela Koutounidou, Fereshteh Dorazehi, Georgia Christoforidou, Jon Matas-Fuentes, Patricia Gerdes, Raquel Garza, Marie E. Jönsson, Anita Adami, Diahann A. M. Atacho, Jenny G. Johansson, Elisabet Englund, Zaal Kokaia, Johan Jakobsson, Christopher H. Douse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The human silencing hub (HUSH) complex binds to transcripts of LINE-1 retrotransposons (L1s) and other genomic repeats, recruiting MORC2 and other effectors to remodel chromatin. How HUSH and MORC2 operate alongside DNA methylation, a centra
Externí odkaz:
https://doaj.org/article/f87b719d040b4e7fb2c512a1ad18871b
Autor:
Juliane F Tampé, Emanuela Monni, Sara Palma-Tortosa, Emil Brogårdh, Charlotta Böiers, Arne G Lindgren, Zaal Kokaia
Publikováno v:
PLoS ONE, Vol 19, Iss 10, p e0300946 (2024)
Aging profoundly affects the immune system leading to an increased propensity for inflammation. Age-related dysregulation of immune cells is implicated in the development and progression of numerous age-related diseases such as: cardiovascular diseas
Externí odkaz:
https://doaj.org/article/5e8fafeb8d254dfb8e8896aba1b97a36
Autor:
Estefanía Estévez-Priego, Martina Moreno-Fina, Emanuela Monni, Zaal Kokaia, Jordi Soriano, Daniel Tornero
Publikováno v:
Stem Cell Reports, Vol 18, Iss 1, Pp 205-219 (2023)
Summary: Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain. Here we investigated whether neuronal cultures derived f
Externí odkaz:
https://doaj.org/article/962ce87c1e414f1eb010c6a04fda8b20
Autor:
Ana Gonzalez-Ramos, Eliška Waloschková, Apostolos Mikroulis, Zaal Kokaia, Johan Bengzon, Marco Ledri, My Andersson, Merab Kokaia
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract Gamma-aminobutyric acid (GABA)-releasing interneurons modulate neuronal network activity in the brain by inhibiting other neurons. The alteration or absence of these cells disrupts the balance between excitatory and inhibitory processes, lea
Externí odkaz:
https://doaj.org/article/a2e6959621cd4950a88ad99f5f68143b
Autor:
David O. Dias, Jannis Kalkitsas, Yildiz Kelahmetoglu, Cynthia P. Estrada, Jemal Tatarishvili, Daniel Holl, Linda Jansson, Shervin Banitalebi, Mahmood Amiry-Moghaddam, Aurélie Ernst, Hagen B. Huttner, Zaal Kokaia, Olle Lindvall, Lou Brundin, Jonas Frisén, Christian Göritz
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-24 (2021)
Fibrotic scar tissue limits central nervous system regeneration. Here, Dias et al. show that fibrotic scarring is common in mice and humans, following distinct lesions to the adult brain and spinal cord, and derives from a discrete population of GLAS
Externí odkaz:
https://doaj.org/article/b2cf5ecacb394539a29e9965db99ad35
Autor:
Marita Grønning Hansen, Cecilia Laterza, Sara Palma‐Tortosa, Giedre Kvist, Emanuela Monni, Oleg Tsupykov, Daniel Tornero, Naomi Uoshima, Jordi Soriano, Johan Bengzon, Gianvito Martino, Galyna Skibo, Olle Lindvall, Zaal Kokaia
Publikováno v:
Stem Cells Translational Medicine, Vol 9, Iss 11, Pp 1365-1377 (2020)
Abstract Several neurodegenerative diseases cause loss of cortical neurons, leading to sensory, motor, and cognitive impairments. Studies in different animal models have raised the possibility that transplantation of human cortical neuronal progenito
Externí odkaz:
https://doaj.org/article/181e28f31b85430e89ba814c4933f424
Autor:
Wei Wang, Elena Di Nisio, Valerio Licursi, Emanuele Cacci, Giuseppe Lupo, Zaal Kokaia, Sergio Galanti, Paolo Degan, Sara D’Angelo, Patrizio Castagnola, Sara Tavella, Rodolfo Negri
Publikováno v:
Life, Vol 12, Iss 11, p 1827 (2022)
We analyzed the morphology and the transcriptomic changes of human neural stem progenitor cells (hNSPCs) grown on laminin in adherent culture conditions and subjected to simulated microgravity for different times in a random positioning machine appar
Externí odkaz:
https://doaj.org/article/068c6363fc754d738bc440627f36ee8c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Stem cell therapy using human skin-derived neural precursors holds much promise for the treatment of stroke patients. Two main mechanisms have been proposed to give rise to the improved recovery in animal models of stroke after transplantation of the
Externí odkaz:
https://doaj.org/article/a37299cedb1641459dcd01c31ee717c7
Autor:
Anna Maria Tolomeo, Cecilia Laterza, Eleonora Grespan, Federica Michielin, Isaac Canals, Zaal Kokaia, Maurizio Muraca, Onelia Gagliano, Nicola Elvassore
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Recent advancements in cell engineering have succeeded in manipulating cell identity with the targeted overexpression of specific cell fate determining transcription factors in a process named transcriptional programming. Neurogenin2 (NGN2) is suffic
Externí odkaz:
https://doaj.org/article/70fb9a7e10ef467b87f3bb33ca6e744c
Autor:
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Härtig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The past decade has brought tremendous progress in diagnostic and therapeutic options for cerebrovascular diseases as exemplified by the advent of thrombectomy in ischemic stroke, benefitting a steeply increasing number of stroke patients and potenti
Externí odkaz:
https://doaj.org/article/b0240d81d38449e096924c6f8ac55632