Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4

Autor: Jonas Nørskov Søndergaard, Simon J. van Heeringen, Maaike W. G. Looman, Chunling Tang, Vassilis Triantis, Pauline Louche, Eva M. Janssen-Megens, Anieta M. Sieuwerts, John W. M. Martens, Colin Logie, Hendrik G. Stunnenberg, Marleen Ansems, Gosse J. Adema

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Dendritic cell (DC)-based immunotherapy makes use of the DC’s ability to direct the adaptive immune response toward activation or inhibition. DCs perform this immune orchestration in part by secretion of selected cytokines. The most potent anti-inf

Externí odkaz: https://doaj.org/article/ddbaab4a79cd4ec38bc9f51fd0f60db0

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells

Autor: Malou Zuidscherwoude, Maaike W. G. Looman, Anieta M. Sieuwerts, Jonas Nørskov Søndergaard, Marcel Smid, Gosse J. Adema, Vanja de Weerd, John A. Foekens, John W.M. Martens, Marleen Ansems, Annemarie M.A. de Graaf

Publikováno v: Breast Cancer Research and Treatment, 149(3), 693-703. Springer New York
Breast Cancer Research and Treatment, 149, 693-703
Breast Cancer Research and Treatment
Breast Cancer Research and Treatment, 149, 3, pp. 693-703

Breast cancer is one of the most common causes of cancer-related deaths in women. The estrogen receptor (ERα) is well known for having growth promoting effects in breast cancer. Recently, we have identified DC-SCRIPT (ZNF366) as a co-suppressor of E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41694ec83b22c4314913915d56438a7
https://doi.org/10.1007/s10549-015-3281-y

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