Zobrazeno 1 - 10
of 95
pro vyhledávání: '"ZK-93426"'
Autor:
Scott C. Harvey, Katrina L. Foster, Rancia Cummings, Marin Garcia, James H. Woods, Dynesha Mason, Harry L. June, Xiaoyan Li, Jason B. Cook, James M. Cook, Shannan McCane, Collette Grey, William J. A. Eiler, Peter F. McKay
Publikováno v:
Alcoholism: Clinical & Experimental Research. 29:1390-1401
Background Previous research has implicated the alpha5-containing GABAA receptors of the hippocampus in the reinforcing properties of alcohol. In the present study, a selective GABAA alpha5 benzodiazepine inverse agonist (e.g., RY 023) was used in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d3dabf1213a29f38c40b4de662d2da
https://doi.org/10.1097/01.alc.0000175073.94575.86
https://doi.org/10.1097/01.alc.0000175073.94575.86
Publikováno v:
European Journal of Neuroscience. 17:2716-2726
The mesocortical and mesolimbic dopaminergic (DAergic) pathways are activated by either aversive or rewarding stimuli. The functional tone of these DAergic neurons also increases during the execution of cognitive tasks. The present study was designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a82a2cb5970c6e266f4b4dbced3b66cd
https://doi.org/10.1046/j.1460-9568.2003.02689.x
https://doi.org/10.1046/j.1460-9568.2003.02689.x
Publikováno v:
Expert Opinion on Investigational Drugs. 7:499-518
Enhancing the release of acetylcholine (ACh) in the brain is one approach to increasing neuronal activity, restoring central cholinergic tone and improving attention and cognition. ACh release is modulated by both ligand-gated (gamma-amino butyric ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f04f6730267cb646d09a56bca4f05e8
https://doi.org/10.1517/13543784.7.4.499
https://doi.org/10.1517/13543784.7.4.499
Autor:
Rhonda Cox, Lucas Torres, Jackie J. Mellor-Burke, Margaret L. Hite, Harry L. June, Scott E. Duemler, Charity R Cason, Terri L. Greene, Ting-Kai Li, Lawrence Lumeng, James M. Murphy, John A. Williams
Publikováno v:
Brain Research. 734:19-34
The present study investigated dose dependence and time course effects of the benzodiazepine (BDZ) partial inverse agonist, RO19-4603 (0.005–0.30 mg/kg) alone, and in combination with the BDZ receptor antagonists flumazenil, ZK 93426, and CGS 8216
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a93f68c18f4dfc083a4e6bd9aa4e40a3
https://doi.org/10.1016/0006-8993(96)00276-4
https://doi.org/10.1016/0006-8993(96)00276-4
Publikováno v:
Psychopharmacology. 123:361-373
The effects of a single dose of scopolamine alone and in combination with ZK 93426 (a beta-carboline antagonist at the GABAA/BZ receptor complex with weak inverse agonist activity) were tested in two studies. In one study (study 1) the emphasis of en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca8b9f3f70dc5d688876f5d15ebbcab
https://doi.org/10.1007/bf02246647
https://doi.org/10.1007/bf02246647
Autor:
Martin Sarter, Jill McGaughy
Publikováno v:
Psychopharmacology. 117:340-357
An operant task for the measurement of sustained attention or vigilance in rats was characterized. The task requires the animals to respond to the presentation of visual signals (presented for 25, 50, or 500 ms) by operating one lever ("hits") and to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da614e8ec2a6e587a789715ff1c30ec
https://doi.org/10.1007/bf02246109
https://doi.org/10.1007/bf02246109
Publikováno v:
Psychopharmacology. 117:178-185
The β-carboline ZK 93 426, a benzodiazepine-antagonist with weak inverse agonist activity, was administered intravenously to human volunteers at a dose of 0.04mg/kg when they initially reached slow-wave sleep during their night's sleep. Eight subjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adfc03b22784d2a9bce05877544572f
https://doi.org/10.1007/bf02245185
https://doi.org/10.1007/bf02245185
Publikováno v:
Journal of psychopharmacology (Oxford, England). 6(3)
It has been suggested from pharmacological studies in animals that ZK 93426 may improve memory and other cognitive processes in humans. Scopolamine has been used to model aspects of memory impairment. To test the effects of ZK 93426 alone and in comb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0502b1c870db3ed11dcd77c07e3e98f8
https://pubmed.ncbi.nlm.nih.gov/22291384
https://pubmed.ncbi.nlm.nih.gov/22291384
Publikováno v:
Journal of Psychopharmacology. 8:141-147
Benzodiazepine receptor (BZR) ligands have been demonstrated to affect the performance in tasks measuring attentional abilities. In such tasks, subjects typically are required to discriminate visual and/or auditory stimuli. The possibility that the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b32de0a4e20924a2cfd444ceaa140b
https://doi.org/10.1177/026988119400800301
https://doi.org/10.1177/026988119400800301
Publikováno v:
Brain Research Bulletin. 34:407-412
Rats were trained to stable performance in a conditional brightness discrimination task and then received infusions of ibotenic acid or vehicle into the basal forebrain. Following 2 weeks of recovery, animals were retested in the original discriminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::906c4fad4bc3fdf4b90970f28df82a6e
https://doi.org/10.1016/0361-9230(94)90037-x
https://doi.org/10.1016/0361-9230(94)90037-x