Zobrazeno 1 - 10
of 40
pro vyhledávání: '"ZK-93423"'
Autor:
Huang Qi, Chunrong Ma, Brad Harris, Mundla S. Reddy, Phil Skolnick, Hernando Diaz-Arauzo, James M. Cook, Ruth McKernan, Eric Cox
Publikováno v:
Journal of Medicinal Chemistry. 41:2537-2552
A pharmacophore and an alignment rule have previously been reported for BzR agonist ligands. The design and synthesis of 6-(propyloxy)-4-(methoxymethyl)-β-carboline-3-carboxylic acid ethyl ester (6-PBC, 24, IC50 = 8.1 nM) was based on this pharmacop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79e81d35b6cb1cfd68c17e05abf63c6e
https://doi.org/10.1021/jm970460b
https://doi.org/10.1021/jm970460b
Publikováno v:
Brain Research Bulletin. 28:605-611
beta-Carboline agonists produced a left shift of the GABA concentration-chloride uptake curve or a reduction in the maximal increase in GABA-stimulated 36Cl- uptake depending on their concentration. The enhancement of the GABA effect occurs only at l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306407ec541d1019f38a7fefc0141905
https://doi.org/10.1016/0361-9230(92)90110-j
https://doi.org/10.1016/0361-9230(92)90110-j
Autor:
Helen C. Jackson, David J. Nutt
Publikováno v:
European Journal of Pharmacology. 193:179-184
The pharmacology of the hypothermia induced by benzodiazepine and beta-carboline full agonists in mice has been investigated using partial agonists and antagonists from both chemical series. The benzodiazepine antagonist flumazenil (10 mg/kg i.p.) bl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127fca2e554816abbaf40bdae84a5f37
https://doi.org/10.1016/0014-2999(91)90034-n
https://doi.org/10.1016/0014-2999(91)90034-n
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 14:249-260
1. Neurobehavioral survey of inverse agonist FG 7142 was performed employing a novel anxiety paradigm namely FR-2 Two-Way crossover in a shuttle box. 2. FG syndrome was found to be similar to learned helplessness following shock treatment. Significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbcf448524f1cd60e22072805e4f01a3
https://doi.org/10.1016/0278-5846(90)90105-p
https://doi.org/10.1016/0278-5846(90)90105-p
Akademický článek
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Publikováno v:
European journal of pharmacology. 236(1)
The benzodiazepine receptor agonists, flurazepam, zolpidem, ZK 93423, and the benzodiazepine inverse agonist, FG 7142, all produced hypothermia when injected i.p. in mice. These compounds are structurally different and do not have the same affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34426eb39df5c7aa549d94809bc94204
https://pubmed.ncbi.nlm.nih.gov/8391449
https://pubmed.ncbi.nlm.nih.gov/8391449
Autor:
Helen C. Jackson, David J. Nutt
Publikováno v:
European journal of pharmacology. 185(2-3)
The benzodiazepine full agonist loprazolam and the β-carboline ZK 93423 produced hypothermia in mice (1–30 mg/kg i.p). Maximal effects were seen at relatively low doses of these compounds. In contrast, the partial agonists Ro 17-1812 (a benzodiaze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe51613fb03e24685d6320c6d286861
https://pubmed.ncbi.nlm.nih.gov/1979276
https://pubmed.ncbi.nlm.nih.gov/1979276
Publikováno v:
British Journal of Pharmacology. 86:357-366
The muscle relaxant action of ZK 93423 (6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate ethyl ester), a novel beta-carboline with agonistic properties at the benzodiazepine receptor, was examined by assessing its effect on the tonic electrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1fe0ccc8ce59fe02daf61c788c4f98
https://doi.org/10.1111/j.1476-5381.1985.tb08904.x
https://doi.org/10.1111/j.1476-5381.1985.tb08904.x
Publikováno v:
Psychopharmacology. 83:233-239
The discriminative stimulus properties of three beta-carboline derivatives were studied in three groups of rats trained, respectively, to discriminate diazepam (2.5 mg/kg IP), chlordiazepoxide (CDP, 5 mg/kg IP) or pentylenetetrazol (PTZ, 15 mg/kg IP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff7c3789d94b005c90229e1d5f4d700
https://doi.org/10.1007/bf00464787
https://doi.org/10.1007/bf00464787
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 321:260-264
The potent benzodiazepine receptor ligands beta-carboline-3-carboxylic acid ethyl ester (beta-CCE) and the corresponding methylester (beta-CCM) administered i.v. depressed segmental dorsal root potentials in spinal cats, reversed the prolongation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d682eed0ab1be0d398985b6cc0340915
https://doi.org/10.1007/bf00498510
https://doi.org/10.1007/bf00498510