Zobrazeno 1 - 10
of 729
pro vyhledávání: '"ZFN"'
Publikováno v:
Зерновое хозяйство России, Vol 16, Iss 3, Pp 18-26 (2024)
Over the past few decades, haploid biotechnologies have become an integral part of breeding programs for many crops. Using the strategy of doubling haploids induced in the culture of gametic cells and tissues in vitro, through androgenesis, gynogenes
Externí odkaz:
https://doaj.org/article/ba51c19fe17f4054ab207cc863798bed
Autor:
Subaya Manzoor, Sajad Un Nabi, Tariq Rasool Rather, Gousia Gani, Zahoor Ahmad Mir, Ab Waheed Wani, Sajad Ali, Anshika Tyagi, Nazia Manzar
Publikováno v:
Frontiers in Genome Editing, Vol 6 (2024)
Modern agriculture has encountered several challenges in achieving constant yield stability especially due to disease outbreaks and lack of long-term disease-resistant crop cultivars. In the past, disease outbreaks in economically important crops had
Externí odkaz:
https://doaj.org/article/54ea0a05ea3d4994a5a91cc7d2d93471
Autor:
Arunkumar Singh Koijam, Kabrambam Dasanta Singh, Bunindro Singh Nameirakpam, Reena Haobam, Yallappa Rajashekar
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 170, Iss , Pp 115951- (2024)
Drug addiction is a complex disease affected by numerous genetic and environmental factors. Brain regions in reward pathway, neuronal adaptations, genetic and epigenetic interactions causing transcriptional enhancement or repression of multiple genes
Externí odkaz:
https://doaj.org/article/8c5f6d3e0ff84c8da300647583d2394f
Autor:
Roman Krzanowski
Publikováno v:
Zagadnienia Filozoficzne w Nauce, Vol 73, Pp 7-13 (2022)
This special edition of Philosophical Problems in Science (Zagadnienia Filozoficzne w Nauce or ZFN) focuses on concepts of information and computing. On reading this issue, you may be surprised by the absence of traditional perspectives and themes th
Externí odkaz:
https://doaj.org/article/1bda955708bf42dba880fa300f149ca8
Publikováno v:
National Science Open, Vol 2 (2023)
In recent decades, gene-editing technologies, typically based on deoxyribonucleases to specifically modify genomic sequences, have dramatically remodeled various aspects of life sciences, including fundamental research, breeding, and medical therapeu
Externí odkaz:
https://doaj.org/article/1a87e2cab37d40beb958a19cca20fee7
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14057 (2023)
Cardiovascular diseases, particularly coronary artery disease (CAD), remain the leading cause of death worldwide in recent years, with myocardial infarction (MI) being the most common form of CAD. Atherosclerosis has been highlighted as one of the dr
Externí odkaz:
https://doaj.org/article/10dfe28a00b34dbea77e4deea2fcfd65
Publikováno v:
Frontiers in Genome Editing, Vol 4 (2023)
Lessons learned from decades-long practice in the transplantation of hematopoietic stem and progenitor cells (HSPCs) to treat severe inherited disorders or cancer, have set the stage for the current ex vivo gene therapies using autologous gene-modifi
Externí odkaz:
https://doaj.org/article/7106183c0655472c80c786b209d022eb
Autor:
Zifeng Cui, Hui Liu, Hongfeng Zhang, Zhaoyue Huang, Rui Tian, Lifang Li, Weiwen Fan, Yili Chen, Lijie Chen, Sen Zhang, Bhudev C. Das, Konstantin Severinov, Inga Isabel Hitzeroth, Priya Ranjan Debata, Zhuang Jin, Jiashuo Liu, Zheying Huang, Weiling Xie, Hongxian Xie, Bin Lang, Ji Ma, Haiyan Weng, Xun Tian, Zheng Hu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1466-1478 (2021)
Zinc-finger nucleases (ZFNs), transcription activator-like endonucleases (TALENs), and CRISPR-associated Cas9 endonucleases are three major generations of genome editing tools. However, no parallel comparison about the efficiencies and off-target act
Externí odkaz:
https://doaj.org/article/2f11fed289fb4cdd859d753a95202f12
Optimization of AAV6 transduction enhances site-specific genome editing of primary human lymphocytes
Autor:
Geoffrey L. Rogers, Chun Huang, Robert D.E. Clark, Eduardo Seclén, Hsu-Yu Chen, Paula M. Cannon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 198-209 (2021)
Adeno-associated virus serotype 6 (AAV6) is a valuable reagent for genome editing of hematopoietic cells due to its ability to serve as a homology donor template. However, a comprehensive study of AAV6 transduction of hematopoietic cells in culture,
Externí odkaz:
https://doaj.org/article/9fdee5f6efeb40e4b94781cdff956508
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells rem
Externí odkaz:
https://doaj.org/article/d1ce988184354b54b4107b2f9529c336