Zobrazeno 1 - 10
of 141
pro vyhledávání: '"ZENG-HONG LI"'
Throughout the course of the SARS-CoV-2 pandemic, genetic variation has contributed to the spread and persistence of the virus. For example, various mutations have allowed SARS-CoV-2 to escape antibody neutralization or to bind more strongly to the r
Externí odkaz:
http://arxiv.org/abs/2403.14202
We use Direct Coupling Analysis (DCA) to determine epistatic interactions between loci of variability of the SARS-CoV-2 virus, segmenting genomes by month of sampling. We use full-length, high-quality genomes from the GISAID repository up to October
Externí odkaz:
http://arxiv.org/abs/2112.12957
We compute the allele frequencies of the alpha (B.1.1.7), beta (B.1.351) and delta (B.167.2) variants of SARS-CoV-2 from almost two million genome sequences on the GISAID repository. We find that the frequencies of a majority of the defining mutation
Externí odkaz:
http://arxiv.org/abs/2109.02962
Publikováno v:
2023 Rep. Prog. Phys. 86 052601
This review is about statistical genetics, an interdisciplinary topic between statistical physics and population biology. The focus is on the phase of quasi-linkage equilibrium (QLE). Our goals here are to clarify under which conditions the QLE phase
Externí odkaz:
http://arxiv.org/abs/2105.01428
Genome-wide epistasis analysis is a powerful tool to infer gene interactions, which can guide drug and vaccine development and lead to a deeper understanding of microbial pathogenesis. We have considered all complete SARS-CoV-2 genomes deposited in t
Externí odkaz:
http://arxiv.org/abs/2010.01260
We consider a population evolving due to mutation, selection and recombination, where selection includes single-locus terms (additive fitness) and two-loci terms (pairwise epistatic fitness). We further consider the problem of inferring fitness in th
Externí odkaz:
http://arxiv.org/abs/2006.16735
Autor:
Pelckmans, Kristiaan, Zeng, Hong-Li
We consider the problem of learning a classifier from observed functional data. Here, each data-point takes the form of a single time-series and contains numerous features. Assuming that each such series comes with a binary label, the problem of lear
Externí odkaz:
http://arxiv.org/abs/2002.09763
The interactions between players of prisoner's dilemma (PD) game are reconstructed with evolutionary game data. All participants play the game with their counterparts and gain corresponding rewards during each round of the game. However, their strate
Externí odkaz:
http://arxiv.org/abs/2002.09105
Autor:
Zeng, Hong-Li, Aurell, Erik
As a problem in data science the inverse Ising (or Potts) problem is to infer the parameters of a Gibbs-Boltzmann distributions of an Ising (or Potts) model from samples drawn from that distribution. The algorithmic and computational interest stems f
Externí odkaz:
http://arxiv.org/abs/2002.05222
Autor:
Zeng, Hong-Li, Aurell, Erik
Publikováno v:
Phys. Rev. E 101, 052409 (2020)
The genetic composition of a naturally developing population is considered as due to mutation, selection, genetic drift and recombination. Selection is modeled as single-locus terms (additive fitness) and two-loci terms (pairwise epistatic fitness).
Externí odkaz:
http://arxiv.org/abs/2001.02173