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Synthesis of new 4-HPR analogues and use of PET imaging to support the development of drug candidates

Autor: Patruno I., Thomson D., Mody N., Windhorst A. D., Poot A. J., Vugts D. J., Dall'Angelo S., Zanda M.

Publikováno v: Poster at EMIM 2019

Fenretinide (4-HPR) is a synthetic retinoid which has been investigated for decades as an anticancer agent and more recently as a potential drug to treat metabolic syndrome. Here we synthesised a library of 4-HPR analogues - using a SAR approach - wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ff75f307e7a62868b7cc6dfc0abf945e
https://doi.org/10.5281/zenodo.3952481

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KEMTUB012-NI2, a novel potent tubulysin analog that selectively targets hypoxic cancer cells and is potentiated by cytochrome p450 reductase downregulation

Autor: Lazzari P, Spiga M, Sani M, Zanda M, Fleming IN

Publikováno v: Hypoxia, Vol Volume 5, Pp 45-59 (2017)

Paolo Lazzari,1 Marco Spiga,1 Monica Sani,1,2 Matteo Zanda,2,3 Ian N Fleming4 1KemoTech s.r.l., Parco Scientifico della Sardegna, Pula, Cagliari, 2C.N.R. – Istituto di Chimica del Riconoscimento Molecolare, Sezione ‘A. Quilico’, Milano, Italy;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::094d6454f722638911ef4e62bf7dabd0
https://www.dovepress.com/kemtub012-ni2-a-novel-potent-tubulysin-analog-that-selectively-targets-peer-reviewed-article-HP

Trifluoromethyl group as a bioisosteric replacement of aliphatic nitro group in CB, receptor positive allosteric modulators (PAMs)

Autor: Zanda M

Publikováno v: 22th international symposium on fluorine Chemistry, Oxford (UK), 22-27/7/2018
info:cnr-pdr/source/autori:Zanda M/congresso_nome:22th international symposium on fluorine Chemistry/congresso_luogo:Oxford (UK)/congresso_data:22-27%2F7%2F2018/anno:2018/pagina_da:/pagina_a:/intervallo_pagine

aa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::a1a22ae6e911cdc6eeaf2ba7e2c46a3e
https://publications.cnr.it/doc/404427