Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Z. S. Shprakh"'
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 13, Iss 2-1, Pp 316-332 (2023)
Liposomes are one of the most well-known and promising nanoscale drug delivery systems. Liposomal medicinal products are successfully used in clinical practice for cardiovascular, oncological, dermatological, and other indications. The development of
Externí odkaz:
https://doaj.org/article/4e60d2a7f704403587226ef2e5845e80
Autor:
E. V. Ignateva, I. V. Yartseva, Z. S. Shprakh, A. P. Bud'ko, L. V. Ektova, D. A. Kozin, V. Yu. Reshetnyak, O. V. Nesterova, E. A. Pankratova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 10, Iss 3, Pp 88-94 (2021)
Introduction. Indolocarbazole derivatives are of increasing scientific interest for practical oncology. A number of N-glycosides, indolo[2,3-a] carbazole under the laboratory code LCS, were synthesized in the laboratory of chemical synthesis of the N
Externí odkaz:
https://doaj.org/article/fc4644ba786d4cac8104170bc04a9510
Autor:
D. A. Kozin, Z. S. Shprakh, V. Yu. Reshetnyak, O. V. Nesterova, I. N. Avertseva, G. M. Rodionova
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 4, Pp 128-135 (2020)
Introduction. Currently, more than 600 thousand people a year are affected by malignant tumors on the territory of the Russian Federation. Despite the large selection of antitumor drugs and the variety of mechanisms of their action, the effectiveness
Externí odkaz:
https://doaj.org/article/194137cc14854787a3f68186eea93780
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 9, Iss 4, Pp 93-98 (2020)
Introduction. Quantitative assessment of the active substance is necessary and perhaps the most significant part of the drug quality control. Validation of the analytical methods of quantitative assessment ensures their compliance with high requireme
Externí odkaz:
https://doaj.org/article/450c53cb94374261a314cab42fc32600
Autor:
Z. S. Shprakh
Publikováno v:
Регуляторные исследования и экспертиза лекарственных средств, Vol 10, Iss 3, Pp 184-191 (2020)
Open borders of the present-day pharmaceutical market call for improvement and harmonisation of the legal basis underlying drug circulation. Part of the overall process of harmonisation of regulatory requirements is the alignment of the terminologica
Externí odkaz:
https://doaj.org/article/e31b9a08435445129e4f3187e0cff878
Autor:
I. D. Gulyakin, L. L. Nikolaeva, M. V. Dmitrieva, N. A. Oborotova, E. V. Ignatieva, N. A. Dmitricheva, I. V. Yartseva, Z. S. Shprakh
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 118-122 (2019)
In order to ensure reliable and accurate results, the authors carried out the validation procedure developed technique for spectrophotometric quantification of the active substance for the lyophilized liposomal formulation of national hydrophobic ant
Externí odkaz:
https://doaj.org/article/5fb6cc02d6134201a32942286d819812
Autor:
I. D. Gulyakin, L. L. Nikolaeva, M. V. Dmitrieva, O. L. Orlova, A. P. Polozkova, N. A. Oborotova, E. V. Ignatieva, N. A. Dmitricheva, I. V. Yartseva, Z. S. Shprakh
Publikováno v:
Разработка и регистрация лекарственных средств, Vol 0, Iss 4, Pp 62-67 (2019)
The work is dedicated to the development of technology for obtaining a freeze-dried dosage form LHS-1208 and the establishment of methods of quality control of the drug. The authors have shown spectrophotometric analysis techniques and flash chromato
Externí odkaz:
https://doaj.org/article/c758b46251224c65b6a7a11af9cbe183
Autor:
E. V. Ignatieva, I. V. Yartseva, Z. S. Shprakh, A. P. Kolpaksidi, M. V. Dmitrieva, A. V. Lantsova, L. L. Nikolaeva, I. R. Prosalkova
Publikováno v:
Russian Journal of Biotherapy. 21:61-71
Background. A glycoside derivative of indolocarbazole LHS-1269, one of the new drugs selectively affecting tumors, which was first synthesized at the N.N. Blokhin National Medical-Research Center of Oncology of the Ministry of Health of Russia, is of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a6baa9d664d8aa5d239ca23fb0257d7
https://doi.org/10.17650/1726-9784-2022-21-3-61-71
https://doi.org/10.17650/1726-9784-2022-21-3-61-71
Autor:
M. P. Kiseleva, L. M. Borisova, V. V. Delektorskaya, Z. S. Shprakh, S. V. Ustinkina, I. Yu. Kubasova
Publikováno v:
Russian Journal of Biotherapy. 21:50-60
Background. Expression evaluation of somatostatin receptors (SSTRs) in tumor cells is necessary for the reasonable use of therapy directed at such receptors.Aim. The affinity determination of the original analogue of somatostatin cyphetrylin for SSTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e5a4ccf176369da3b9572ae4b57e2f
https://doi.org/10.17650/1726-9784-2022-21-3-50-60
https://doi.org/10.17650/1726-9784-2022-21-3-50-60
Autor:
E. A. Pankratova, Z. S. Shprakh
Publikováno v:
Russian Journal of Biotherapy. 21:10-20
Neuroendocrine tumors (NET) is a rare pathology characterized by dysfunction of the pituitary gland and endocrine glands. The survival prognosis depends on the stage of the disease at which the malignant growth was detected.The study objective was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba3093f32262ae97555ccbd697df07f9
https://doi.org/10.17650/1726-9784-2022-21-1-10-20
https://doi.org/10.17650/1726-9784-2022-21-1-10-20