Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Z. Razzaque"'
Publikováno v:
The Scientific World Journal, Vol 1, Pp 17-17 (2001)
Calcitonin, CGRP, adrenomedullin, and amylin require both CRLR (calcitonin-gene receptor like receptor) and receptor activity modifying proteins (RAMP1, RAMP2, and RAMP3) in different combinations for expression of selective, functional receptors[1].
Externí odkaz:
https://doaj.org/article/6dffa562d4fd4df2bca066791a8923b4
Publikováno v:
British Journal of Clinical Pharmacology. 53:266-274
AIMS: 5-HT1B-receptor mediated vasoconstriction of cranial arteries is a potential mechanism by which 5-HT1B/1D-receptor agonists such as sumatriptan produce their antimigraine effects. 5-HT1B-receptors exist in other blood vessels which may give ris
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6673acf32b75aa334df5f7aa08fb38a0
https://doi.org/10.1046/j.0306-5251.2001.01536.x
https://doi.org/10.1046/j.0306-5251.2001.01536.x
Publikováno v:
European Journal of Pharmacology. 395:61-68
Neurogenic vasodilation in cranial arteries may be an important mechanism in the pathogenesis of migraine headache. We describe a novel, in vitro assay to characterise neurogenic vasodilator responses in endothelium-denuded segments of rabbit isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7382078a92a94ca2eef15e5f4cd85d
https://doi.org/10.1016/s0014-2999(00)00153-9
https://doi.org/10.1016/s0014-2999(00)00153-9
Autor:
S. L. Shepheard, Josephine A. Stanton, Margaret S. Beer, Austin John Reeve, Victor G. Matassa, Francine Sternfeld, Michael I. Graham, Jeanette Longmore, Richard Alexander Jelley, Richard Hargreaves, Alexander Richard Guiblin, Leslie J. Street, Bindi Sohal, Z. Razzaque, Howard B. Broughton, Raymond Baker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1825-1830
Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole (8) is the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc8a3bdfb587bc6ad4d07bf750ad82b7
https://doi.org/10.1016/0960-894x(96)00324-1
https://doi.org/10.1016/0960-894x(96)00324-1
Publikováno v:
European Journal of Pharmacology. 250:125-131
The effects of three tachykinin NK1 receptor antagonists (L-668,169, (±)-RP 67580, and (±)-CP 96,345) were examined for their ability to antagonise responses evoked by substance P O-methyl ester (a selective NK1 receptor agonist) in isolated neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483a7444a500f45083fb83cfa79a211a
https://doi.org/10.1016/0014-2999(93)90629-v
https://doi.org/10.1016/0014-2999(93)90629-v
Autor:
Z. Razzaque, Richard Hargreaves, Leslie J. Street, Richard Alexander Jelley, Josephine A. Stanton, Bindi Sohal, S. L. Shepheard, Victor G. Matassa, Jeanette Longmore, Alexander Richard Guiblin, Francine Sternfeld, Raymond Baker, Austin John Reeve, Margaret S. Beer, Michael I. Graham, Howard B. Broughton
Publikováno v:
ChemInform. 27
Optimisation of a series of 5-(heterocyclyl)tryptamines led to the identification of the symmetrically substituted, N-4 linked 1,2,4-triazole as the best indole C-5 substituent for 5-HT1D receptor affinity and selectivity. The triazole (8) is the mos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74847d6bfb22278ab8881dec6ddab101
https://doi.org/10.1002/chin.199649147
https://doi.org/10.1002/chin.199649147
Publikováno v:
British Journal of Pharmacology. 112:176-178
1. The effects of the NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on NK1-agonist evoked contractions were compared in isolated rings of guinea-pig tracheal smooth muscle. 2. (+/-)-CP 96,345 and CP 99,994 were similarly effective in antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2acb90031b308ae7b0391a02975f21be
https://doi.org/10.1111/j.1476-5381.1994.tb13048.x
https://doi.org/10.1111/j.1476-5381.1994.tb13048.x
Publikováno v:
European journal of pharmacology. 458(3)
The actions of bradykinin and its metabolite des-Arg 9 bradykinin are mediated through activation of bradykinin B 2 and B 1 receptors, respectively. The aim of the present study was to characterize native bradykinin receptors focusing on induction an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa55a41fb16fc50a189835c19249b77
https://pubmed.ncbi.nlm.nih.gov/12504789
https://pubmed.ncbi.nlm.nih.gov/12504789
Autor:
Michael J Cumberbatch, Richard Hargreaves, Leslie J. Street, Bindi Sohal, G. Seabrook, David J. Williamson, R. G. Hill, M. Beer, J. Stanton, S. L. Shepheard, Z. Razzaque, J. Longmore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e75bea3605eb917bc9fd20faa4d785
https://doi.org/10.1159/000061584
https://doi.org/10.1159/000061584
Autor:
L. Maskell, Jenny Longmore, Raymond G. Hill, M A Heald, Z. Razzaque, John D. Pickard, M. S. Beer
Sumatriptan is a 5-HT1B/1D-receptor agonist which also has affinity for 5-HT1F-receptors. The vasoconstrictor effects of sumatriptan are thought to be 5-HT1B-receptor mediated and these receptors have been shown to be expressed in human cranial blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a6f272e20d2bf764b064be07b91cc4
https://europepmc.org/articles/PMC2014192/
https://europepmc.org/articles/PMC2014192/