Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Z. Pittel"'
Publikováno v:
Journal of Neurochemistry. 70:1991-1997
Recent studies suggest that apolipoprotein E (apoE) plays a specific role in brain cholinergic function and that the E4 allele of apoE (apoE4), a major risk factor for Alzheimer's disease (AD), may predict the extent of cholinergic dysfunction and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00d2fd0da0e7d3568c5599db57cea34
https://doi.org/10.1046/j.1471-4159.1998.70051991.x
https://doi.org/10.1046/j.1471-4159.1998.70051991.x
Publikováno v:
Life Sciences. 59:1651-1657
Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal cortex, significantly declines with advanced age. We have previously demonstrated that DHEA prevents the reduction in non-amyloidogenic APP processing, following prolonge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b1ea7cdc518a2d065f7f6d98efea0b
https://doi.org/10.1016/0024-3205(96)00496-1
https://doi.org/10.1016/0024-3205(96)00496-1
Autor:
Eliahu Heldman, Haim Meshulam, Jacob Barg, Abraham Fisher, Rachel Haring, A. Wengier, David Gurwitz, H.D. Danenberg, Ronit Pinkas-Kramarski, Y. Karton, Z. Pittel, D. Marciano
Publikováno v:
Biochemical and Biophysical Research Communications. 213:15-23
Processing of beta-amyloid precursor protein (APP) is coupled to several neurotransmitter receptors, including m1 muscarinic (m1AChR), and is associated with decreased amyloid deposition. Muscarinic agonist-stimulated APP secretion and membrane APP w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea054acd4316154646fd0898783ecb14
https://doi.org/10.1006/bbrc.1995.2092
https://doi.org/10.1006/bbrc.1995.2092
Publikováno v:
Journal of neuroendocrinology. 25(10)
Maternal care is the newborn's first experience of social interaction, and this influences infant survival, development and social competences throughout life. We recently found that postpartum blocking of the endocannabinoid receptor-1 (CB1R) altere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be35096c31aa222eac8b3ffd340335af
https://pubmed.ncbi.nlm.nih.gov/23895426
https://pubmed.ncbi.nlm.nih.gov/23895426
Autor:
Antonela Caccamo, Abraham Fisher, Kim N. Green, Rachel Brandeis, Hanoch Elkon, Z. Pittel, Lauren M. Billings, Salvatore Oddo, Nira Bar-Ner, Frank M. LaFerla
Publikováno v:
Alzheimer's & Dementia. 2
contextual memory was also measured. Conclusions: We have identified a number of development candidates aimed at targeting either improved symptomatic therapy or disease slowing. This ‘multiple shots on goal’ approach using multiple platforms and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::860ab39ebe9498c00b387b50037dcebb
https://doi.org/10.1016/j.jalz.2006.05.285
https://doi.org/10.1016/j.jalz.2006.05.285
Autor:
A, Fisher, R, Brandeis, R, Haring, N, Bar-Ner, M, Kliger-Spatz, N, Natan, H, Sonego, I, Marcovitch, Z, Pittel
Publikováno v:
Journal of neural transmission. Supplementum. (62)
The M1 muscarinic agonists AF102B, AF150(S)AF267B--i) restored cognitive impairments in several animal models for AD with an excellent safety margin; ii) elevated alpha-APPs levels; iii) attenuated vicious cycles induced by A beta, and inhibited A be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d0efd0bfdec06c5ebdfe4a7bd6f394d
https://pubmed.ncbi.nlm.nih.gov/12456063
https://pubmed.ncbi.nlm.nih.gov/12456063
Autor:
Abraham Fisher, Z. Pittel, Michal Kliger-Spatz, Itzhak Marcovitch, Hagar Sonego, Rachel Brandeis, Rachel Haring, Nira Bar-Ner, Niva Natan
Publikováno v:
Ageing and Dementia Current and Future Concepts ISBN: 9783211837962
The Ml muscarinic agonists AF102B, AF150(S) & AF267B — i) restored cognitive impairments in several animal models for AD with an excellent safety margin; ii) elevated α-APPs levels; iii) attenuated vicious cycles induced by Aβ, and inhibited Aβ-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::844c1156e3e9f46a5da7b41acc28e670
https://doi.org/10.1007/978-3-7091-6139-5_18
https://doi.org/10.1007/978-3-7091-6139-5_18
Autor:
Daniel M. Michaelson, Z. Pittel, Abraham Fisher, Rachel Brandeis, Rachel Haring, Shira Chapman
Publikováno v:
Annals of the New York Academy of Sciences. 920
A cholinergic hypofunction in Alzheimer's disease (AD) may lead to formation of beta-amyloids that might impair the coupling of M1 muscarinic ACh receptors (mAChRs) with G proteins. This disruption in coupling can lead to decreased signal transductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8339d806297a4bfbac8617151b467a
https://pubmed.ncbi.nlm.nih.gov/11193170
https://pubmed.ncbi.nlm.nih.gov/11193170
Autor:
Eliahu Heldman, Rachel Haring, Yoel Kloog, Abraham Fisher, Z. Pittel, Rivka Levy, N. Eshhar, D. Marciano, Zvi Vogel
Publikováno v:
Advances in Behavioral Biology ISBN: 9781461374350
Selective muscarinic agonists that are directed at the ml muscarinic acetylcholine receptor (Ml mAChR) have been suggested as a rational treatment of Alzheimer’s disease (AD) (Fisher and Barak, 1995). Such muscarinic receptor agonists may activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb62b262c53cfffcb109aa56d2f11d8d
https://doi.org/10.1007/978-1-4615-5337-3_72
https://doi.org/10.1007/978-1-4615-5337-3_72
Autor:
Daniele Marciano, Rachel Haring, Eliahu Heldman, Einat Sadot, Z. Pittel, Abraham Fisher, Yishai Karton, David Gurwitz, Haim Meshulam, Irit Ginzburg, Rachel Brandeis, Leah Behar, Jacob Barg
Publikováno v:
Alzheimer Disease ISBN: 9781461286608
Restoration of ACh levels or replacement with an M1 (or m1) muscarinic agonist may be effective in treating at least some of the cognitive symptoms in Alzheimer’s disease (AD), (see Court and Perry, 1991; Fisher and Barak, 1994). Treatment approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7edd2faf1dc2f42e4948ab6d53f39a
https://doi.org/10.1007/978-1-4612-4116-4_47
https://doi.org/10.1007/978-1-4612-4116-4_47