Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

Autor: Cédric Auffray, Naishitha Anaparthy, Douglas T. Fearon, Z. Larkin Kelley, Mikala Egeblad, Arnaud Pommier, Ran Yan, Nicoletta Memos, Christine A. Iacobuzio-Donahue, Alizee Gouronnec, Scott K. Lyons, Jean Albrengues

Publikováno v: Science. 360

Chronic stress as a survival tactic Most patients with pancreatic ductal adenocarcinoma (PDA) develop liver metastases after surgical removal of their primary tumor. These metastases are thought to potentially arise from quiescent disseminated cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9803813c6d7ab7136c51eba738c6eb7
https://doi.org/10.1126/science.aao4908

Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

Autor: Elizabeth A. Musgrove, Krishna Epari, Gokce Askan, Katia Nones, Virginia Papangelis, Roberta Zappasodi, Rita T. Lawlor, John W. Chen, Marina Pajic, Umesh Bhanot, Taha Merghoub, Vincent Lam, Claudio Bassi, Mehrdad Nikfarjam, Adnan Nagrial, Jaswinder S. Samra, Z. Larkin Kelley, Michael Texler, Ray Asghari, Conrad Leonard, Venessa T. Chin, Paul Timpson, Benjamin Greenbaum, Stefania Beghelli, Olca Basturk, Nan Q. Nguyen, Amitabha Das, Jonathan Fawcett, Peter Bailey, Sanjay Mukhedkar, Oliver Hofmann, Sacha Gnjatic, Anthony J. Gill, Marta Łuksza, Ali Drury, Hilda High, Nikolajs Zeps, Mithat Gonen, James G. Kench, John Alec Moral, Duncan J. Mcleod, Marc A. Attiyeh, Douglas T. Fearon, Peter Hodgkinson, Jennifer Q. Zhang, Peter J. Allen, Andrew V. Biankin, Michael Hatzifotis, Peter Grimison, Joseph Saglimbeni, David Williams, Nigel B. Jamieson, Amber L. Johns, Stephen H. Kazakoff, Vladimir Makarov, Anubhav Mittal, Felicity Newell, Angela Steinmann, Skye McKay, Cindy Forest, Chris Worthley, Nicola Waddell, Sancha Martin, R. Scott Mead, Charbel Sandroussi, Olivera Grbovic-Huezo, Jennifer Arena, Andrew Barbour, David Hermann, Mark Pinese, Arnold J. Levine, Charles Ian Ormsby Cary, Chelsie O'Connor, Neil D. Merrett, Vinod P. Balachandran, Romain Remark, Peter H. Cosman, Annabel Goodwin, Julia N. Zhao, P. Martin, Kellee Slater, Venkateswar Addala, Ashleigh Morgan, Mark Brooke-Smith, Jeremy L. Humphris, Claire Vennin, Darren Pavey, Miriam Merad, Timothy J. C. Bruxner, Mo Ballal, Mary Hodgin, Jedd D. Wolchok, Martin Smoragiewicz, Angelika N. Christ, Vincenzo Corbo, Caroline Cooper, Oliver Holmes, Pamela Mukhopadhyay, Sean M. Grimmond, Jennifer K. Loo, Kasim Ismail, Yasin Senbabaoglu, Steven D. Leach, Maria Beilin, Thomas J. O'Rourke, Danielle Froio, Benjamin D. Medina, Brian Herbst, Ronald P. DeMatteo, Ralph H. Hruban, Ann-Marie Patch, Lorraine A. Chantrill, Timothy A. Chan, Lesley Andrews, Nick Pavlakis, Mehreen Arshi, David R. Fletcher, Christopher L. Wolfgang, Virginia James, Christine A. Iacobuzio-Donahue, Kynan Feeney, Sean C. Warren, Angela Chou, Jianmin Wu, David K. Chang, Allan D. Spigelman, Mohsen Abu-Akeel, Andrew Ruszkiewicz, Andreia V. Pinho, Katherine Tucker, John V. Pearson, Marc D. Jones, Alina Stoita, Daniel K. Wells, Craig Nourse, Judy Kirk, Maria Scardoni, Nadeem Riaz, Aldo Scarpa, Christina Xu, Scott Wood, James R. Eshleman, Peter Wilson, Andrew D. Clouston

Pancreatic ductal adenocarcinoma is a lethal cancer with fewer than 7% of patients surviving past 5 years. T-cell immunity has been linked to the exceptional outcome of the few long-term survivors, yet the relevant antigens remain unknown. Here we us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b7f9aa936c28cb4a2fa0ab891f3a63
http://hdl.handle.net/11562/977179

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