Bacterial citrullinated epitopes generated by Porphyromonas gingivalis infection—a missing link for ACPA production

Autor: Dirkjan van Schaardenburg, Ute Nonhoff, Madeleine Jenning, Vijay Joshua, Karl Skriner, Jimmy Ytterberg, Anca I. Catrina, Lotte A van de Stadt, Bianka Marklein, Thomas Häupl, Gerd R Burmester, Z. Konthur, Roman A. Zubarev

Publikováno v: Annals of the rheumatic diseases, 79(9), 1194-1202. BMJ Publishing Group

ObjectivesPorphyromonas gingivalis (P.g.) is discussed to be involved in triggering self-reactive immune responses. The aim of this study was to investigate the autocitrullinated prokaryotic peptidylarginine deiminase (PPAD) from P.g. CH2007 (RACH200

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e90f6e39e31a0debc209db7082c30f
https://doi.org/10.1136/annrheumdis-2019-216919

PAWG Pilot Study on Quantification of SARS-CoV-2 Monoclonal Antibody - Part 1

Autor: W Mi, R D Josephs, J E Melanson, X Dai, Y Wang, R Zhai, Z Chu, X Fang, M-P Thibeault, B B Stocks, J Meija, M Bedu, G Martos, S Westwood, R I Wielgosz, Q Liu, T L Teo, H Liu, Y J Tan, M Öztuğ, E Saban, T Kinumi, K Saikusa, R J Schneider, M G Weller, Z Konthur, C Jaeger, M Quaglia, C Mussell, G Drinkwater, C Giangrande, H Vaneeckhoutte, A Boeuf, V Delatour, J E Lee, G O'Connor, R Ohlendorf, A Henrion, P J Beltrão, S M Naressi Scapin, Y B Sade

Publikováno v: Metrologia. 59:08001

Main text Under the auspices of the Protein Analysis Working Group (PAWG) of the Comité Consultatif pour la Quantité de Matière (CCQM) a pilot study, CCQM-P216, was coordinated by the Chinese National Institute of Metrology (NIM), National Researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0dd251348018058a524ea2cbdeb2c80e
https://doi.org/10.1088/0026-1394/59/1a/08001

Genetic rearrangements (VDJ/CSR/SHM) (PP-080)

Autor: S. Sakamoto, Y. Pasman, A. Iivanainen, A. Ekman, M. Aida, Y. Shimada, M. Simonet, C. Kano, H. Kuoppamaa, Y. Yu, V. Sievert, J. Wang, M. D. Lange, S. Fagarasan, N. A. Begum, T. He, W. Fu, S. Fujimoto, Y. Agata, L. Huang, D. Jones, M. Nozaki, E. Jouvin-Marche, A. Stanlie, P. Swanson, T. Kina, C. Zhu, T. S. Lim, Z. Yu, R. Lu, M. Larijani, S. K. Singh, E. Dzneladze, O. Hansen, H. Mori, K. Su, M. Ekblom, K. Suzuki, R. Seggewiss, Y. Li, M. Yamashita, T. Nakayama, N. Sakaguchi, A. K. Kaushik, G. X. Liang, K. Kitamura, H. Nagaoka, E. Smith, L. Stenke, R. Shinkura, T. Moritan, Z. Zhang, N. MInato, V. Juvonen, W. Xie, T. Honjo, Z. Konthur, K. M. Marran-Nichol, S. Mustjoki, J. Demongeot, H. Lehrach, S. S. Saini, V. Saridakis, M. Niku, P. N. Marche, S. Kakinuma, M. Nakata, K. Maeda, Z. Wang, K. Masuda, N. Tamaki, A. Cagigi, K. Zhang, I. Yanagihara, T. H. Tran, K. Skriner, M. Muramatsu, Q. Pan-Hammarström, A. Kreutzman, G. E. Wu, K. Porkka, V. Kairisto, J. Liljavirta, J. Huang, R. Ouchida, S. Hong, R. Singh, K. Wakae, F. Thuderoz, C. Rosner, F. Rubelt

Publikováno v: International Immunology. 22:iv91-iv94

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c0b623aaf4c8b1045c67305b5cbf040
https://doi.org/10.1093/intimm/dxq260

FRI0201 Rituximab Treated Non Responder Rheumatoid Arthritis Patients Are Generating A New Autoantibody Repertoire

Autor: Karl Skriner, Z. Konthur, Gerd R. Burmester, M.M. Wiemkes, T. Häupl

Publikováno v: Annals of the Rheumatic Diseases. 75:503.2-503

Background Rituximab (RTX) has shown clinical efficacy but up to 40% of RTX treated rheumatoid arthritis (RA) patients are poor responders (ref:1) and the commonly used RA biomarkers ( RF/ACPA ) are poor predictors for therapy response. Others report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a27a6be3dd56f9bb82366680823b0eb1
https://doi.org/10.1136/annrheumdis-2016-eular.2977

A7.11 IGA autoantigens – a link between the gut and the anti-TNF therapy response in rheumatoid arthritis patients analysed in two independent clinical trials

Autor: M.M. Wiemkes, Karl Skriner, J.M. Hollidt, Ute Nonhoff, Gerd R. Burmester, Z. Konthur, J. Detert, T. Braun

Publikováno v: Annals of the Rheumatic Diseases. 74:A78.3-A79

Background So far no mechanism for non response to biologicals targeting TNFα has been described, despite one third of rheumatoid arthritis patients treated are Non-Responder. A link to the gut microbiota and its ability to drive an autoimmune disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4fdc0e2846dc204493f67acb940dd55b
https://doi.org/10.1136/annrheumdis-2015-207259.181