Zobrazeno 1 - 10 of 45 pro vyhledávání: '"Z. Kaymakcalan"'
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Potential predictive biomarkers of adalimumab response in patients with hidradenitis suppurativa*
Autor: Z. Kaymakcalan, Yonghao Cao, D M Conlon, L Sidur, F Hong, Carolyn A. Cuff, Y Fang, Melanie C. Ruzek, Kristine M. Smith
Publikováno v: British Journal of Dermatology. 185:804-814
Background Adalimumab provides significant efficacy for patients with hidradenitis suppurativa (HS), which was demonstrated by at least 50% of patients achieving a clinical response by week 12 that was maintained through to week 168 in the PIONEER tr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eb82552402565731a13263e59f58f67
https://doi.org/10.1111/bjd.20097
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3
Adalimumab Induces a Wound Healing Profile in Patients with Hidradenitis Suppurativa by Regulating Macrophage Differentiation and Matrix Metalloproteinase Expression
Autor: Jing Wang, Bohdan P. Harvey, Erin Murphy, Z. Kaymakcalan, Yonghao Cao, Feng Hong, Melanie Ruzek
Publikováno v: The Journal of investigative dermatology. 141(11)
Adalimumab (ADA) is the only Food and Drug Administration‒approved treatment for moderate-to-severe hidradenitis suppurativa, whereas etanercept and certolizumab-pegol have been shown to be ineffective, suggesting that the mechanism of action of AD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b3c99302d31698281d0be86e6a3aee
https://pubmed.ncbi.nlm.nih.gov/33965402
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4
Akademický článek
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5
THU0002 THERAPEUTIC ANTI-TNF BIOLOGIC AGENTS EXHIBIT FUNCTIONAL DIFFERENCES IN BLOCKING TNF-INDUCED EFFECTS ON HUMAN MONOCYTES IN VITRO
Autor: Bohdan P. Harvey, Z. Kaymakcalan
Publikováno v: Poster Presentations.
Background: Therapeutic anti-TNF biologic agents can be distinct in their structure, such as etanercept, a human TNFRII- Fc fusion protein, as compared to adalimumab, a human IgG molecule, and/or in their binding to TNF as shown by crystal structures
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7aae81d052ae5ed2ae045f6589d0e7d
https://doi.org/10.1136/annrheumdis-2019-eular.4796
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6
SAT0058 Adalimumab:tnf complexes are cleared more efficiently by human osteoclasts than those with etanercept through fcg-receptor binding and internalisation
Autor: B.P. Harvey, Z. Kaymakcalan, J. Cohen-Solal
Publikováno v: Saturday, 16 JUNE 2018.
Background TNF-alpha (TNFa) has been shown to contribute to osteoclastogenesis (OCgenesis) independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast (OC) development. We have previously demonstrated that TNF enhan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f079a25e0fdb4a1eca60e857af7e84e
https://doi.org/10.1136/annrheumdis-2018-eular.3804
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7
FRI0034 Adalimumab reduces CXCR4 expression during inflammatory arthritis and in fibroblast-like synoviocytes and osteoclasts under chronic TNF exposure
Autor: S Westmoreland, Z. Kaymakcalan, M Ruzek, Bohdan P. Harvey, L Li, H Knight, M Konrad
Publikováno v: Poster Presentations.
Background The CXCL12/CXCR4 chemokine axis has been implicated in the pathogenesis of RA. The expression of this chemokine and receptor has been shown to be increased in RA synovium, and moreover, CXCR4 levels in synovium have been correlated with jo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b708a8a2f6ff381cb0386456e02b88f
https://doi.org/10.1136/annrheumdis-2017-eular.2982
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9
Characterization of Noncovalent Complexes of Recombinant Human Monoclonal Antibody and Antigen Using Cation Exchange, Size Exclusion Chromatography, and BIAcore
Autor: K. Grant, Ira S. Krull, L.C. Santora, P. Sakorafas, Z. Kaymakcalan
Publikováno v: Analytical Biochemistry. 299:119-129
The binding of fully human monoclonal antibodies (MAbs) D2E7 and 2SD4 to their antigen, human tumor necrosis factor-alpha (TNFalpha), was investigated by BIAcore, cation exchange (CIEX), and size exclusion liquid chromatography (SEC) using ultraviole
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096e2cba8e54c9b59f83917f3f5ca02c
https://doi.org/10.1006/abio.2001.5380
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10
AB0063 Complex of Adalimumab and TNF Induces A Divergent Proteomic Profile in TNF-Stimulated Human Osteoclast Precursors To That Resembling A Monocytic Cell
Autor: Y. Tian, B.P. Harvey, C. Hu, Z. Kaymakcalan, Dongdong Wang
Publikováno v: Annals of the Rheumatic Diseases. 75:918.2-918
Background TNF has been shown to contribute to osteoclastogenesis independently and in conjunction with M-CSF or RANKL, two key cytokines involved in osteoclast (OC) development. We have previously demonstrated that TNF enhances the kinetics of RANKL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86f9cc2a8219b9b1e481ef2845417663
https://doi.org/10.1136/annrheumdis-2016-eular.2982
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