Binding to leukocytes and induction of TNFα production involve different sites within the lipid-A region of LPS-like molecules

Autor: Z. Hmama, Jean-Pierre Revillard, Anne Mey, Hans Binz, Gerard Normier

Publikováno v: International Journal of Immunopharmacology
International Journal of Immunopharmacology, Elsevier, 1994, 16 (5-6), pp.413-417. ⟨10.1016/0192-0561(94)90030-2⟩
International Journal of Immunopharmacology, 1994, 16 (5-6), pp.413-417. ⟨10.1016/0192-0561(94)90030-2⟩

The induction of TNF alpha synthesis in whole blood culture assay and isolated peripheral blood mononuclear cells was investigated, using LPS from Klebsiella pneumoniae and two water-soluble 34 kDa derivatives designed as acylpolygalactoside (APG) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4442abe1c1cb0e39ff9bac618971b7
https://doi.org/10.1016/0192-0561(94)90030-2

Binding of a Bacterial Acylpoly(1,3)Galactoside to Human Blood Leucocytes

Autor: Panaye G, Edouard Kouassi, Hans Binz, G. Normier, Z. Hmama, Jean-Pierre Revillard, Delassan S

Publikováno v: Scandinavian Journal of Immunology. 36:11-20

The binding of a 34-kDa (mol. wt.) acylpoly(1,3)galactoside (APG) extracted from a membrane proteoglycan of Klebsiella pneumoniae to human blood leucocytes was investigated. APG is made of a long poly(1,3)galactose chain, a core-like region and a lip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dacead757d18743d1efacb9055fcc0c8
https://doi.org/10.1111/j.1365-3083.1992.tb02935.x

Attenuation of HLA-DR expression by mononuclear phagocytes infected with Mycobacterium tuberculosis is related to intracellular sequestration of immature class II heterodimers

Autor: Z, Hmama, R, Gabathuler, W A, Jefferies, G, de Jong, N E, Reiner

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 161(9)

MHC class II expression was examined in macrophages infected with Mycobacterium tuberculosis. IFN-gamma increased the surface expression of class II molecules in THP-1 cells and this was markedly reduced in cells infected with M. tuberculosis. Despit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::be9881c27fa31346912f56ddd72ebddb
https://pubmed.ncbi.nlm.nih.gov/9794422

CD14 and CD11b mediate serum-independent binding to human monocytes of an acylpolygalactoside isolated from Klebsiella pneumoniae

Autor: G Normier, Z. Hmama, A. Mey, Jean-Pierre Revillard, H Binz

Publikováno v: Infection and Immunity
Infection and Immunity, American Society for Microbiology, 1994, 62 (5), pp.1520-1527. ⟨10.1128/IAI.62.5.1520-1527.1994⟩

A water-soluble acylpolygalactosyl (APG) of 34 kDa was obtained from the Klebsiella pneumoniae membrane by alkaline hydrolysis and delipidation. APG comprises a poly(1,3)galactose chain, a core, and a lipid moiety made of a glucosamine disaccharide w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03a66465b9c963184888adcb9ac1456
https://hal.archives-ouvertes.fr/hal-02912164

Monocyte cytokine secretion induced by chemically-defined derivatives of Klebsiella pneumoniae

Autor: Claude Vincent, J. Wijdenes, Jean-Pierre Revillard, Gerard Normier, Gerard Lina, Z. Hmama, H Binz

Publikováno v: Clinical and experimental immunology. 89(1)

SUMMARYThe capacity of a K. pneumoniae membrane proteoglycan (Kp-MPG) and four of its chemically defined derivatives to activate human monocytes was studied by measuring immunoreactive IL-1β, IL-6 and tumour necrosis factor-alpha (TNF-α) in culture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f19c583f954d170b4931eaaaaa61f7
https://pubmed.ncbi.nlm.nih.gov/1628418