Výsledky vyhledávání - "Z R, Vlahcevic"

Akademický článek

Hormonal regulation of cholesterol 7alpha-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat

Autor: W M Pandak, D M Heuman, K Redford, R T Stravitz, J Y Chiang, P B Hylemon, Z R Vlahcevic

Publikováno v: Journal of Lipid Research, Vol 38, Iss 12, Pp 2483-2491 (1997)

In primary cultures of rat hepatocytes, transcription of the cholesterol 7alpha-hydroxylase gene is induced synergistically by glucocorticoid and thyroid hormones. The objective of the present study was to evaluate the role of endogenous glucocortico

Externí odkaz: https://doaj.org/article/07fadeb554a8476c893d58444424d6b5

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Akademický článek

Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation

Autor: Y P Rao, R T Stravitz, Z R Vlahcevic, E C Gurley, J J Sando, P B Hylemon

Publikováno v: Journal of Lipid Research, Vol 38, Iss 12, Pp 2446-2454 (1997)

The feedback repression of cholesterol 7alpha-hydroxylase transcriptional activity and mRNA levels by taurocholate (TCA) occurs via a protein kinase C (PKC)-dependent signal. To determine whether bile acids could activate PKC indirectly via generatio

Externí odkaz: https://doaj.org/article/834e6267283645e9871a33373a71f4bd

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Akademický článek

Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes.

Autor: R T Stravitz, Z R Vlahcevic, E C Gurley, P B Hylemon

Publikováno v: Journal of Lipid Research, Vol 36, Iss 6, Pp 1359-1369 (1995)

Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes. The addition of taurocholate (25 microM) for 6 h decreased cho

Externí odkaz: https://doaj.org/article/7744bbdcc70544dfb899534631550d8d

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Akademický článek

Regulation of rat hepatic 3 alpha-hydroxysteroid dehydrogenase in vivo and in primary cultures of rat hepatocytes.

Autor: R T Stravitz, Z R Vlahcevic, W M Pandak, A Stolz, P B Hylemon

Publikováno v: Journal of Lipid Research, Vol 35, Iss 2, Pp 239-247 (1994)

In the bile acid biosynthetic pathways of humans and the rat, hepatic 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSDH) catalyzes the stereospecific reduction of the 3-oxo group of bile acid precursors. In addition, 3 alpha-HSDH may serve to shuttl

Externí odkaz: https://doaj.org/article/80c698880ed3496dbac6c584b8aa8b79

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Effects of CYP7A1 overexpression on cholesterol and bile acid homeostasis

Autor: Robert A. Fisher, William M. Pandak, C. Schwarz, Kaye Redford, Phillip B. Hylemon, Darrell H. Mallonee, K. Valerie, Z R Vlahcevic, Douglas M. Heuman

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 281:G878-G889

The initial and rate-limiting step in the classic pathway of bile acid biosynthesis is 7α-hydroxylation of cholesterol, a reaction catalyzed by cholesterol 7α-hydroxylase (CYP7A1). The effect of CYP7A1 overexpression on cholesterol homeostasis in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e16b053d7b62469a5d632fe74f8dd9b
https://doi.org/10.1152/ajpgi.2001.281.4.g878

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Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis

Autor: William M. Pandak, Narayan G. Avadhani, Phillip B. Hylemon, Z R Vlahcevic, E. Hall, Darrell H. Mallonee, K. Valerie

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 281:G293-G301

In the liver, sterol 27-hydroxylase (CYP27) participates in the classic and alternative pathways of bile acid biosynthesis from cholesterol (Chol). In extrahepatic tissues, CYP27 converts intracellular Chol to 27-hydroxycholesterol (27OH-Chol), which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deced126b6ffcaf7a82c32146ce5ab13
https://doi.org/10.1152/ajpgi.2001.281.1.g293

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Down-regulation of the rat hepatic sterol 27-hydroxylase

Autor: J Mullick, Phillip B. Hylemon, Z. R. Vlahcevic, Y P Rao, R. T. Stravitz, Darrell H. Mallonee, Narayan G. Avadhani

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 70:1-14

In vitro and in vivo studies have shown that the sterol 27-hydroxylase (CYP27) gene is transcriptionally repressed by hydrophobic bile acids. The molecular mechanism(s) of repression of CYP27 by bile acids is unknown. To identify the bile acid respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ebcd3150c01540ed8074b7678609bea
https://doi.org/10.1016/s0960-0760(99)00099-0

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Akademický článek

An in vivo evaluation of the quantitative significance of several potential pathways to cholic and chenodeoxycholic acids from cholesterol in man

Autor: L Swell, J Gustafsson, C C Schwartz, L G Halloran, H Danielsson, Z R Vlahcevic

Publikováno v: Journal of Lipid Research, Vol 21, Iss 4, Pp 455-466 (1980)

The present study was designed to obtain more definitive information in man on the metabolic pathways to chenodeoxycholic acid and to cholic acid via a pathway not involving an initial 7 alpha-hydroxylation of cholesterol. Four bile fistula patients

Externí odkaz: https://doaj.org/article/9d67d01192674ca6ade0b69cd4db5c8c

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Akademický článek

Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat.

Autor: D M Heuman, P B Hylemon, Z R Vlahcevic

Publikováno v: Journal of Lipid Research, Vol 30, Iss 8, Pp 1161-1171 (1989)

Hepatic bile acid synthesis is thought to be under negative feedback control by bile salts in the enterohepatic circulation, acting at the level of cholesterol 7 alpha-hydroxylase (C7 alpha H), the initial and rate-limiting step in the bile acid bios

Externí odkaz: https://doaj.org/article/ed78dba2e3764054b84e8709e238cb41

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