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The NS3 proteinase domain of hepatitis C virus is a zinc-containing enzyme

Autor: Z. Hostomska, M Stempniak, B.R. Nodes, Z. Hostomsky

Publikováno v: Journal of Virology. 71:2881-2886

NS3 proteinase of hepatitis C virus (HCV), contained within the N-terminal domain of the NS3 protein, is a chymotrypsin-like serine proteinase responsible for processing of the nonstructural region of the HCV polyprotein. In this study, we examined t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285a397e6ca49032b80fedafd9808274
https://doi.org/10.1128/jvi.71.4.2881-2886.1997

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What is the orientation of DNA polymerases on their templates?

Autor: S. F. J. Le Grice, S.H. Hughes, K. Lentz, Z. Hostomsky, Eddy Arnold

Publikováno v: Journal of Virology. 70:2679-2683

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5173796c7e1bccd91bea2ea08a5875b3
https://doi.org/10.1128/jvi.70.5.2679-2683.1996

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Subunit composition and domain structure of the Spo0A sporulation transcription factor of Bacillus subtilis

Autor: James A. Hoch, Z Hostomsky, J. M. Whiteley, T H Bird, Mark A. Strauch, G B Spiegelman, Ronald B. Tjalkens, J K Grimsley

Publikováno v: Journal of Biological Chemistry. 269:16977-16982

The Spo0A transcription factor is responsible for the initiation of sporulation and is active in transcription only after phosphorylation by a specific signal transduction pathway, the phosphorelay. The effect of phosphorylation on the physical prope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1dc70298d7315af94ad76dc6307c1bea
https://doi.org/10.1016/s0021-9258(19)89485-1

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Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesis

Autor: J Taylor, Z Hostomska, Z Hostomsky, T B Fu

Publikováno v: Journal of Virology. 66:3179-3182

From an in vitro analysis of the DNA-synthesizing abilities of certain specifically mutated forms of the heterodimeric reverse transcriptase of human immunodeficiency virus type 1, we can conclude that in a heterodimer, the functionality of p66 is ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91b5ea9db1a55ded6b7ccc2ef2aafccd
https://doi.org/10.1128/jvi.66.5.3179-3182.1992

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Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase

Autor: B.R. Nodes, Z. Hostomsky, Z. Hostomska, J.F. Davies nd, D.A. Matthews

Publikováno v: Journal of Biological Chemistry. 266:14697-14702

The RNase H domain of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase was released from recombinant DHFR-RNase H fusion protein by the action of HIV-1 protease and crystallized as large trigonal prisms that diffract x-rays to at lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eace9673d9eeacea8adc4e906a09cc50
https://doi.org/10.1016/s0021-9258(18)98742-9

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Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines

Autor: C A, Delaney, L Z, Wang, S, Kyle, A W, White, A H, Calvert, N J, Curtin, B W, Durkacz, Z, Hostomsky, D R, Newell

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)

Potent poly(ADP-ribose) polymerase (PARP) inhibitors have been developed that potentiate the cytotoxicity of ionizing radiation and anticancer drugs. The biological effects of two novel PARP inhibitors, NU1025 (8-hydroxy-2-methylquinazolin-4-[3H]one,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c01f8b8f1dca66877b9cd6519475f0a
https://pubmed.ncbi.nlm.nih.gov/10914735

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