Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Z Hong Zhou"'
Autor:
Elizabeth B Draganova, Hui Wang, Melanie Wu, Shiqing Liao, Amber Vu, Gonzalo L Gonzalez-Del Pino, Z Hong Zhou, Richard J Roller, Ekaterina E Heldwein
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011936 (2024)
Nuclear egress is an essential process in herpesvirus replication whereby nascent capsids translocate from the nucleus to the cytoplasm. This initial step of nuclear egress-budding at the inner nuclear membrane-is coordinated by the nuclear egress co
Externí odkaz:
https://doaj.org/article/4ec664c6fbd343e48c9bf997df69f327
Publikováno v:
eLife, Vol 9 (2020)
During herpesvirus infection, egress of nascent viral capsids from the nucleus is mediated by the viral nuclear egress complex (NEC). NEC deforms the inner nuclear membrane (INM) around the capsid by forming a hexagonal array. However, how the NEC co
Externí odkaz:
https://doaj.org/article/2469880ec5a84047bf02675c259545a6
Autor:
Simon Imhof, Jiayan Zhang, Hui Wang, Khanh Huy Bui, Hoangkim Nguyen, Ivo Atanasov, Wong H Hui, Shun Kai Yang, Z Hong Zhou, Kent L Hill
Publikováno v:
eLife, Vol 8 (2019)
The 96-nm axonemal repeat includes dynein motors and accessory structures as the foundation for motility of eukaryotic flagella and cilia. However, high-resolution 3D axoneme structures are unavailable for organisms among the Excavates, which include
Externí odkaz:
https://doaj.org/article/ae870c1baf4a4029ab51a487dfc3a810
Autor:
Kaituo Wang, Sarah Spruce Preisler, Liying Zhang, Yanxiang Cui, Julie Winkel Missel, Christina Grønberg, Kamil Gotfryd, Erik Lindahl, Magnus Andersson, Kirstine Calloe, Pascal F Egea, Dan Arne Klaerke, Michael Pusch, Per Amstrup Pedersen, Z Hong Zhou, Pontus Gourdon
Publikováno v:
PLoS Biology, Vol 17, Iss 4, p e3000218 (2019)
ClC-1 protein channels facilitate rapid passage of chloride ions across cellular membranes, thereby orchestrating skeletal muscle excitability. Malfunction of ClC-1 is associated with myotonia congenita, a disease impairing muscle relaxation. Here, w
Externí odkaz:
https://doaj.org/article/83a7e6f4ff29469c8e807f5e8caa11cf
Autor:
Wei Liu, Xinghong Dai, Jonathan Jih, Karen Chan, Phong Trang, Xuekui Yu, Rilwan Balogun, Ye Mei, Fenyong Liu, Z Hong Zhou
Publikováno v:
PLoS Pathogens, Vol 15, Iss 2, p e1007615 (2019)
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (
Externí odkaz:
https://doaj.org/article/9f162cbda3494a6b9c7cd569d4eff963
Autor:
Zhu Si, Jiayan Zhang, Sakar Shivakoti, Ivo Atanasov, Chang-Lu Tao, Wong H Hui, Kang Zhou, Xuekui Yu, Weike Li, Ming Luo, Guo-Qiang Bi, Z Hong Zhou
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007452 (2018)
Human cytomegalovirus (HCMV) enters host by glycoprotein B (gB)-mediated membrane fusion upon receptor-binding to gH/gL-related complexes, causing devastating diseases such as birth defects. Although an X-ray crystal structure of the recombinant gB e
Externí odkaz:
https://doaj.org/article/753988f7f4f94e23817c7adc12b950c8
Autor:
Kai Xu, Yee-Peng Chan, Birgit Bradel-Tretheway, Zeynep Akyol-Ataman, Yongqun Zhu, Somnath Dutta, Lianying Yan, YanRu Feng, Lin-Fa Wang, Georgios Skiniotis, Benhur Lee, Z Hong Zhou, Christopher C Broder, Hector C Aguilar, Dimitar B Nikolov
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005322 (2015)
Nipah virus (NiV) is a paramyxovirus that infects host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. Here we repo
Externí odkaz:
https://doaj.org/article/d7d53e34d8c04943b73c50bfbe07fb34
Publikováno v:
eLife, Vol 4 (2015)
mRNA transcription in dsRNA viruses is a highly regulated process but the mechanism of this regulation is not known. Here, by nucleoside triphosphatase (NTPase) assay and comparisons of six high-resolution (2.9–3.1 Å) cryo-electron microscopy stru
Externí odkaz:
https://doaj.org/article/0d0f8d0b5be34f09bf296d7672dad2d5
Autor:
Xing Zhang, Huatao Guo, Lei Jin, Elizabeth Czornyj, Asher Hodes, Wong H Hui, Angela W Nieh, Jeff F Miller, Z Hong Zhou
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/edfb5f46a687417a87fd510d60b71c20
Autor:
Karthik Sathiyamoorthy, Jiansen Jiang, Yao Xiong Hu, Cynthia L Rowe, Britta S Möhl, Jia Chen, Wei Jiang, Elizabeth D Mellins, Richard Longnecker, Z Hong Zhou, Theodore S Jardetzky
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004309 (2014)
Epstein-Barr Virus (EBV) is an enveloped double-stranded DNA virus of the gammaherpesvirinae sub-family that predominantly infects humans through epithelial cells and B cells. Three EBV glycoproteins, gH, gL and gp42, form a complex that targets EBV
Externí odkaz:
https://doaj.org/article/8b7acd2542c642678bab7e0320cf2d9c