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Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints

Autor: J, Kuang, G, He, Z, Huang, A R, Khokhar, Z H, Siddik

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(11)

1R,2R-Diaminocyclohexane(trans-diacetato)(dichloro)-platinum(IV) (DACH-acetato-Pt) is a novel platinum-based agent that is highly effective against cisplatin-resistant ovarian tumor cells. To probe its cellular mechanism, the effects of DACH-acetato-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2cc17beb610aa3839d6fadbaff35b892
https://pubmed.ncbi.nlm.nih.gov/11705886

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EGF receptor and p21WAF1 expression are reciprocally altered as ME-180 cervical carcinoma cells progress from high to low cisplatin sensitivity

Autor: N J, Donato, M, Perez, H, Kang, Z H, Siddik, Y H, Ling, R, Perez-Soler

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(1)

Cell cycle regulators and signal transduction pathways can influence apoptotic sensitivity of tumor cells, and we previously described an association between EGFr overexpression, reduced DNA repair activity, and increased apoptotic sensitivity of ME-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3a2a12d2c08b673dcc0318e037857b54
https://pubmed.ncbi.nlm.nih.gov/10656450

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Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner

Autor: T, Furui, R, LaPushin, M, Mao, H, Khan, S R, Watt, M A, Watt, Y, Lu, X, Fang, S, Tsutsui, Z H, Siddik, R C, Bast, G B, Mills

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(12)

Lysophosphatidic acid (LPA) is one of the major growth factors in ascites from ovarian cancer patients and appears to play an important role in proliferation, survival, and invasion of ovarian cancer cells. Recently, several groups have shown that Ed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59b4aff05d0ad9c6c61a2e462818a531
https://pubmed.ncbi.nlm.nih.gov/10632375

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Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV)

Autor: G S, Hagopian, G B, Mills, A R, Khokhar, R C, Bast, Z H, Siddik

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(3)

The compound (1R,2R-diaminocyclohexane)(transdiacetato)(dichloro)platinum(IV) (DACH-acetato-Pt) is a novel platinum-based antitumor agent with clinical potential against cisplatin-resistant disease that is under development in our laboratory. In view

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc2287f899f442fe5921bcb8668c4cce
https://pubmed.ncbi.nlm.nih.gov/10100719

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Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line

Autor: Z H, Siddik, B, Mims, G, Lozano, G, Thai

Publikováno v: Cancer research. 58(4)

The p53 tumor suppressor gene is critical in regulating cell proliferation following DNA damage, and disruption of p53 protein function by mutation has been implicated as a factor responsible for resistance of tumor cells to chemotherapeutic agents.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ccb1d91d3ac806fbc00fae3c0df782b
https://pubmed.ncbi.nlm.nih.gov/9485023

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Phase I clinical and pharmacological study of liposome-entrapped NDDP administered intrapleurally in patients with malignant pleural effusions

Autor: R, Perez-Soler, D M, Shin, Z H, Siddik, W K, Murphy, M, Huber, S J, Lee, A R, Khokhar, W K, Hong

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 3(3)

cis-Bis-neodecanoato-trans-R,R-1,2-diaminocyclohexane platinum(II) (NDDP) is a lipophilic non-cross-resistant platinum compound formulated in large multilamellar liposomes (1-3 micrometer). The maximum tolerated dose (MTD) of liposomal-entrapped NDDP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::894f42266a3570fcda04cbbdee3f10cc
https://pubmed.ncbi.nlm.nih.gov/9815694

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Tetravalent platinum complexes with ammine/amine carrier ligand configuration: circumvention of platinum resistance in vivo

Autor: Z H, Siddik, G, Thai, M, Yoshida, Y P, Zhang, A R, Khokhar

Publikováno v: Anti-cancer drug design. 9(6)

A platinum(II) and three platinum(IV) ammine/cycloalkylamine homologous series, the latter possessing either chloro, acetato or hydroxo axial ligands, were evaluated for efficacies in mice bearing tumor cells sensitive (leukemia L.1210/0 and reticulo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bad7fb288f97d144910453d384b3fb3e
https://pubmed.ncbi.nlm.nih.gov/7880375

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Circumvention of platinum resistance: structure-activity relationship for homologous series of ammine/amine platinum(II) complexes in L1210 cell lines

Autor: M, Yoshida, A R, Khokhar, Z H, Siddik

Publikováno v: Anti-cancer drug design. 9(5)

Ammine/amine dichloroplatinum(II) complexes have been evaluated for structure-activity relationship in wild-type L1210/0, 185-fold cisplatin-resistant L1210/DDP and 39-fold tetraplatin-resistant L1210/DACH murine leukemia cells. The mechanism of resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6730df368dff71adaebcfa27b8694487
https://pubmed.ncbi.nlm.nih.gov/7945726

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