Výsledky vyhledávání - "Z E, Winters"

Akademický článek

Immediate and delayed autologous abdominal microvascular flap breast reconstruction in patients receiving adjuvant, neoadjuvant or no radiotherapy: a meta‐analysis of clinical and quality‐of‐life outcomes

Autor: A. Khajuria, W. N. Charles, M. Prokopenko, A. Beswick, A. L. Pusic, A. Mosahebi, D. J. Dodwell, Z. E. Winters

Publikováno v: BJS Open, Vol 4, Iss 2, Pp 182-196 (2020)

Background Effects of postmastectomy radiotherapy (PMRT) on autologous breast reconstruction (BRR) are controversial regarding surgical complications, cosmetic appearance and quality of life (QOL). This systematic review evaluated these outcomes afte

Externí odkaz: https://doaj.org/article/90db1044363147e38140728c5202bd0e

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Phase III development of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire module for women undergoing breast reconstruction

Autor: Z E Winters, V Balta, H J Thomson, Y Brandberg, A Oberguggenberger, Y Sinove, D Unukovych, M Nava, K Sandelin, H Johansson, J Dobbeleir, P Blondeel, N Bruno, G Catanuto, R Llewellyn-Bennett

Publikováno v: British Journal of Surgery. 101:371-382

Background Comprehensive outcome assessments after breast reconstruction (BRR) require surgery-specific patient-reported outcome measures. The aims of this study were to assess the relevance, acceptability and redundancy of questions/items (phase III

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa483218ae207bf886b1c38a41cfb575
https://doi.org/10.1002/bjs.9397

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International validation of the European Organisation for Research and Treatment of Cancer QLQ-BRECON23 quality-of-life questionnaire for women undergoing breast reconstruction

Autor: Z E Winters, M Afzal, C Rutherford, B Holzner, G Rumpold, R A da Costa Vieira, S Hartup, K Flitcroft, V Bjelic-Radisic, A Oberguggenberger, M Panouilleres, M Mani, G Catanuto, M Douek, J Kokan, P Sinai, M T King, A Spillane, K Snook, F Boyle, J French, E Elder, B Chalmers, M Kabir, I Campbell, A Wong, H Flay, J Scarlet, J Weis, J Giesler, B Bliem, E Nagele, N del Angelo, V Andrade, D Assump¸ão Garcia, F Bonnetain, M Kjelsberg, S William-Jones, A Fleet, S Hathaway, J Elliott, M Galea, J Dodge, A Chaudhy, R Williams, L Cook, S Sethi, P Turton, A Henson, J Gibb, R Bonomi, S Funnell, C Noren, J Ooi, S Cocks, L Dawson, H Patel, L Bailey, S Chatterjee, K Goulden, S Kirk, W Osborne, L Harter, M A Sharif, S Corcoran, J Smith, R Prasad, A Doran, A Power, L Devereux, J Cannon, S Latham, P Arora, S Ridgway, M Coulding, R Roberts, M Absar, T Hodgkiss, K Connolly, J Johnson, K Doyle, N Lunt, M Cooper, I Fuchs, L Peall, L Taylor, A Nicholson

Publikováno v: The British journal of surgery. 105(3)

Background The aim was to carry out phase 4 international field-testing of the European Organisation for Research and Treatment of Cancer (EORTC) breast reconstruction (BRECON) module. The primary objective was finalization of its scale structure. Se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f31b32ce9def9b1efa7065cc678b083
https://pubmed.ncbi.nlm.nih.gov/29116657

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Patient-reported outcomes and their predictors at 2- and 3-year follow-up after immediate latissimus dorsi breast reconstruction and adjuvant treatment

Autor: Z E Winters, M Afzal, V Balta, J Freeman, R Llewellyn-Bennett, Z Rayter, J Cook, R Greenwood, M T King, S Hallam, E Weiler-Mithoff, S Nicholson, P McManus, M Galea, J Benson

Publikováno v: Winters, Z E, Afzal, M, Balta, V, Llewellyn-Bennett, R, Rayter, Z, Cook, J, Greenwood, R J & King, M T 2016, ' Patient-reported outcomes and their predictors at 2-and 3-year follow-up after immediate latissimus dorsi breast reconstruction and adjuvant treatment ', British Journal of Surgery, vol. 103, no. 5, pp. 524-536 . https://doi.org/10.1002/bjs.10102

Background The aim of this study was to estimate the impact 2 and 3 years after surgery of implant-assisted latissimus dorsi (LDI) and autologous latissimus dorsi (ALD) flap breast reconstructions on patient-reported outcomes (PROs), and, secondarily

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996581fd259812c51ecb7de04112926d
https://hdl.handle.net/1983/f63f041b-bfc5-4588-87f8-7456f9908498

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Barriers to accrue to clinical trials and possible solutions

Autor: Peter McCulloch, N Bidad, Clare Griffin, Z E Winters, Rob Horne

Publikováno v: British Journal of Cancer

A systematic review of worldwide phase 3 trials over 9 years showed that a third of all trials close early due to poor accrual (Schroen et al, 2012). The QUEST (Quality of Life after mastectomy and breast reconstruction) feasibility phase 3 trials (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0c4c84f2f844869b2b196d30a7d76a
https://pubmed.ncbi.nlm.nih.gov/24960407

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Learning from the QUEST multicentre feasibility randomization trials in breast reconstruction after mastectomy

Publikováno v: The British journal of surgery. 102(1)

Background Breast reconstruction aims to improve health-related quality of life after mastectomy. However, evidence guiding patients and surgeons in shared decision-making concerning the optimal type or timing of surgery is lacking. Methods QUEST com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f9d580ec8917429874429b9186648b
https://pubmed.ncbi.nlm.nih.gov/25451179

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Integration of patient-reported outcome measures with key clinical outcomes after immediate latissimus dorsi breast reconstruction and adjuvant treatment

Autor: Z E, Winters, J, Haviland, V, Balta, J, Benson, A, Reece-Smith, N, Betambeau, M, Galea

Background Clinical evidence on patient-reported outcome measures (PROMS) in breast reconstruction is lacking. The aim of this study was to evaluate PROMs in implant-assisted latissimus dorsi (LDI) or tissue-only autologous latissimus dorsi (ALD) fla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87219445ddf2faf876b3060dd9b571
https://eprints.soton.ac.uk/365652/

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P53 pathways involving G2 checkpoint regulators and the role of their subcellular localisation

Autor: Z E, Winters

Publikováno v: Journal of the Royal College of Surgeons of Edinburgh. 47(4)

DNA damage activates checkpoint pathways to produce a G1 or G2 cell cycle arrest and DNA repair. G2 checkpoint integrity prevents inappropriate mitosis of unrepaired DNA. Cell cycle progression is determined by cyclin-dependent kinase (CDK) enzymes i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8626f6f0fbb090c59a2fd9cdc692f6d2
https://pubmed.ncbi.nlm.nih.gov/12363184

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Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis

Autor: Z E, Winters, N C, Hunt, M J, Bradburn, J A, Royds, H, Turley, A L, Harris, C J, Norbury

Publikováno v: European journal of cancer (Oxford, England : 1990). 37(18)

The heterodimeric cyclin B/Cdc2 protein kinase governs entry into mitosis, and can be negatively regulated through p53-mediated transcriptional induction of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Ectopic expression of p21(WAF1/CIP1) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ab3dc0163c06740723053728b49f3425
https://pubmed.ncbi.nlm.nih.gov/11720835

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