Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Z A, Darieva"'
Autor:
Boris A. Margulis, Elena B. Lasunskaia, Milton M. Kanashiro, Irina Fridlianskaia, Z. A. Darieva, Mariele S R da Silva
Publikováno v:
Biotechnology and Bioengineering. 81:496-504
Mouse myeloma NS0 cells widely used in hybridoma technology lack the expression of a major stress protein Hsp70 which is the principal component of the basic cellular defense mechanism. These cells rapidly undergo apoptosis at the late-stationary pha
Autor:
Z. A. Darieva, Mariana N. N. Campos, Wilmar Dias da Silva, Thereza Liberman Kipnis, Elena B. Lasunskaia
Publikováno v:
Journal of leukocyte biology. 75(4)
The proinflammatory response of infected macrophages is an important early host defense mechanism against mycobacterial infection. Mycobacteria have been demonstrated to induce proinflammatory gene transcription through the Toll-like receptors, (TLR)
[Constitutive activity of MAP kinase cascades in REF cells transformed by E1A and cHa-ras oncogenes]
Publikováno v:
Tsitologiia. 43(10)
Proteins of Ras family play an important role in regulation of cell growth and proliferation, and their mutations can lead to growth factor-independent proliferation due to constitutive activity of various signal transduction cascades. In the present
Publikováno v:
Tsitologiia. 43(6)
Changes in the levels of mRNAs encoding ion transporters (ATP1B1, NHE1, NKCC1), beta-actin, GAPDH, regulators of proliferation and apoptosis (p53, Bcl-2) and kinase hSGK, involved in cell water regulation, were studied using RT PCR in the peripheral
Publikováno v:
International Journal of Molecular Medicine.
Two BCG vaccine formulations of the Moreau strain, commercially manufactured for anti-tuberculosis vaccination, ID-BCG, or anti-cancer adjuvant therapy, Onco-BCG, were compared for immunogenic activity in vitro. The growth rates of both vaccines in m
Publikováno v:
Tsitologiia. 41(7)
DNA binding activity and intracellular distribution of transcription factor NF-kappa B in primary embryo fibroblast (REF) cells transformed by the complementing oncogenes E1A plus cHa-ras have been studied. By means of a gel retardation assay with a
Autor:
I V, Guzhova, A C, Arnholdt, Z A, Darieva, A V, Kinev, E B, Lasunskaia, K, Nilsson, V M, Bozhkov, A P, Voronin, B A, Margulis
Publikováno v:
Cell stresschaperones. 3(1)
The presence of antibodies against the major stress protein, Hsp70, in patients with autoimmune diseases led us to hypothesize that Hsp70 may occur extracellularly, and could exert chaperoning and regulatory effects on various cells. We examined the
Publikováno v:
Cell stresschaperones. 2(2)
Polypeptides belonging to the Hsp70 major stress protein family and to the NF-kB/Rel multi-functional regulatory complex are known to be involved in cellular defense mechanisms. It was suggested that both systems may interact in cells that respond to
Autor:
A D, Scholl-Engberts, E N, Sokolova, Z A, Darieva, Iu G, Popov, T V, Pospelova, V S, Gurevich
Publikováno v:
Tsitologiia. 34(5)
In view of recent studies showing that cell proliferation of E1Aad5+c-Ha-ras-transformed fibroblasts cannot be regulated by growth factors and phorbol eaters in contrast to normal and E1Aad5-immortalized cell lines, the present work was undertaken to
Publikováno v:
Voprosy onkologii. 37(3)
The ability of growth factors (GF) to stimulate proliferation of rat embryo fibroblast (REF) lines immortalized by E 1A oncogene and transformed by complementing E 1A and c-Ha-ras oncogenes (mutant form) was studied. Unlike untreated REF, those immor