Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Z, Tozuka"'
Akademický článek
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Autor:
N. Yamane, Tomoe Fujita, Z. Tozuka, Yuichi Sugiyama, A. Yamazaki, Mika Maeda, Shinichi Yokota, Yuji Kumagai
Publikováno v:
Journal of Clinical Pharmacy and Therapeutics. 35:169-175
Summary Objective: Fexofenadine is a P-glycoprotein substrate of low bioavailability. It is primarily excreted into faeces as a parent drug via biliary excretion. The predictability from microdose data for the drug absorbed via transporters such as P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87799f62e03a3f07e70078b0d4cf0919
https://doi.org/10.1111/j.1365-2710.2009.01159.x
https://doi.org/10.1111/j.1365-2710.2009.01159.x
Publikováno v:
Xenobiotica. 29:217-229
1. Studies using human liver microsomes and recombinant human cytochrome P450 (P450) enzymes and flavin-containing monooxygenase (FMO) were performed to identify the enzymes responsible for the formation of zotepine metabolites in man. 2. Human liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50edc36bf07b8290c2fcdc0933c65e6b
https://doi.org/10.1080/004982599238623
https://doi.org/10.1080/004982599238623
Autor:
F. P. Guengerich, Z Tozuka, H. Matsuda, K. Takeshita, Kazuhide Iwasaki, Toshiro Niwa, T Hata, T Shiraga
Publikováno v:
Xenobiotica. 25:1063-1071
1. Species-, gender- and strain-related differences in amine sulphoconjugations were studied in 105,000 g supernatants of liver samples isolated from mouse, rat, guinea pig, rabbit, dog, monkey and man and were compared with those of alcoholic and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0098aba689aaed108973965ed2cac773
https://doi.org/10.3109/00498259509061906
https://doi.org/10.3109/00498259509061906
Publikováno v:
Journal of clinical pharmacy and therapeutics. 35(2)
Fexofenadine is a P-glycoprotein substrate of low bioavailability. It is primarily excreted into faeces as a parent drug via biliary excretion. The predictability from microdose data for the drug absorbed via transporters such as P-glycoprotein is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d15b05d01c362bc842c46155bf8a3579
https://pubmed.ncbi.nlm.nih.gov/20456735
https://pubmed.ncbi.nlm.nih.gov/20456735
Publikováno v:
Research communications in molecular pathology and pharmacology. 91(1)
The metabolism of 14C-labeled 7-ethoxycoumarin (7EC) has been investigated in precision-cut liver slices from guinea pigs and dogs. 7EC was incubated with slices in 12-well plates (4 slices/well; n = 3) for up to 8 hr. In addition, a new simple metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::801b4a4768802d7788a3e36deee50bad
https://pubmed.ncbi.nlm.nih.gov/8824930
https://pubmed.ncbi.nlm.nih.gov/8824930
Autor:
A. Togawa, T Hata, Z Tozuka, Toshiro Niwa, Y. Naritomi, T Shiraga, H Kaneko, Kazuhide Iwasaki
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 25(10)
1. Species and sex differences in testosterone hydroxylation and nifedipine oxidation in liver microsomes from rat, dog and monkey have been investigated. 2. The formation of 2 alpha-, 2 beta-, 6 beta-, and 16 alpha-hydroxytestosterone and androstene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2caef668b9958933d7ff5f8358022c5
https://pubmed.ncbi.nlm.nih.gov/8578760
https://pubmed.ncbi.nlm.nih.gov/8578760
Publikováno v:
Research communications in molecular pathology and pharmacology. 86(2)
The interaction of renal clearance between nilvadipine metabolites, M3 and M7, in male and female rats including protein binding and renal excretion was investigated to clarify the mechanisms involved. In male rats, active renal secretion of M7 (the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96c49693b6dca677198786c1228128a7
https://pubmed.ncbi.nlm.nih.gov/7881869
https://pubmed.ncbi.nlm.nih.gov/7881869
Autor:
K, Iwasaki, T, Shiraga, K, Nagase, Z, Tozuka, K, Noda, S, Sakuma, T, Fujitsu, K, Shimatani, A, Sato, M, Fujioka
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(6)
To characterize structures and biological activities of FK506 metabolites, FK506 was incubated with liver microsomes prepared from phenobarbital-treated rats in the presence of NADPH generating system under aerobic condition. Oxidative metabolites fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0edb1c13158bfd4ee41669e5db7ea70
https://pubmed.ncbi.nlm.nih.gov/7507815
https://pubmed.ncbi.nlm.nih.gov/7507815
Akademický článek
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