Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Z, Machková"'
Publikováno v:
Immunopharmacology and immunotoxicology. 13(1-2)
A pharmacokinetic profile of 14C-AdDP with uniformly labelled alanine was investigated. It was shown that the distribution phase after an i.v. administration is very short with a half-life of 2.1 min. The half-life of elimination phase after the i.v.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d059dc45475c249736fe7e708de0e2
https://pubmed.ncbi.nlm.nih.gov/1770213
https://pubmed.ncbi.nlm.nih.gov/1770213
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 13(1)
Binding difference spectra of rat renal and hepatic cytochromes P-450 with cyclosporine A (CsA) were measured. In both cases reversed type I spectra were found with the absorbance maximum at 416 nm and minimum at 378 nm. Apparent spectral dissociatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b26ff8178fbe1c153259081a89480163
https://pubmed.ncbi.nlm.nih.gov/1870359
https://pubmed.ncbi.nlm.nih.gov/1870359
Publikováno v:
Toxicology. 62(3)
The administration of the lipophilic 3,7-bis-(4-trifluoromethylphenyl)-1,5,3,7-dioxadiazocane (TFMPD) to rats induced the following effects on the biosynthesis of DNA in the liver, kidney, thymus and spleen: (a) The utilization of [3H]thymidine for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e858ad25f4dfd6fd72c5c778e86bc877
https://pubmed.ncbi.nlm.nih.gov/2389245
https://pubmed.ncbi.nlm.nih.gov/2389245
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 12(4)
The effect of cyclosporine A (CsA), the immunosuppressant used in transplantation and also in the treatment of some autoimmune diseases, on the microsomal mixed function oxidase (MFO) systems in rat kidney and liver was studied. Since CsA given intra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee9c751665793e6ea126193f9084252e
https://pubmed.ncbi.nlm.nih.gov/2374470
https://pubmed.ncbi.nlm.nih.gov/2374470
Autor:
Z. Machková, V. Černý
Publikováno v:
Collection of Czechoslovak Chemical Communications. 39:1091-1097
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5143c05b1b90ee12287110390f98fb6
https://doi.org/10.1135/cccc19741091
https://doi.org/10.1135/cccc19741091
Autor:
J. Seifert, Z. Machková
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 114:59-63
Like other lipid-soluble xenobiotics, clofibrate (ethyl-2-(4-chlorophenoxy)-2-methylpropanoate) increased the level of microsomal cytochrome P-450 in liver and decreased the utilization of 14C-orotic acid for the synthesis of hepatic cytidine nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1e918cedba9c8e6c5a267055693482
https://doi.org/10.1007/bf00390486
https://doi.org/10.1007/bf00390486
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 6(8)
Muramyl dipeptide (MDP) protection from acrolein, chloroform and carbon tetrachloride toxicity was tested using isolated rat hepatocytes prepared by collagenase perfusion method. Hepatotoxin lethal effects were assessed using trypan blue exclusion an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34fa8c083d86044e787d9783558b09be
https://pubmed.ncbi.nlm.nih.gov/6492941
https://pubmed.ncbi.nlm.nih.gov/6492941
Autor:
J, Seifert, Z, Machková
Publikováno v:
Physiologia Bohemoslovaca. 33(5)
The utilization of (2-14C)orotic acid for the synthesis of cytidine components of the acid-soluble extract and for the RNA cytosine is decreased in the liver of rats which fasted for 24 or 72 h. The depression of the specific activity of the cytidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa417561a55dcac0a6278e39f27dcff0
https://pubmed.ncbi.nlm.nih.gov/6209737
https://pubmed.ncbi.nlm.nih.gov/6209737
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 8(8)
The present study was carried out to investigate the effect of single and multiple doses of N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP) on CCl4-induced hepatotoxicity, and hence some of the mechanisms involved. MDP (8.26 mumol/kg i.v.) was administ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7ed297f417bf46a297a78980241a99e2
https://pubmed.ncbi.nlm.nih.gov/3747640
https://pubmed.ncbi.nlm.nih.gov/3747640
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