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Akademický článek
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Autor:
R. J. Siarey, Z. Galdzicki
Publikováno v:
Genes, Brain and Behavior. 2:167-178
Mental retardation in Down's syndrome, human trisomy 21, is characterized by developmental delays, language and memory deficits and other cognitive abnormalities. Neurophysiological and functional information is needed to understand the mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04e094fdd6227061ca457056bf243bac
https://doi.org/10.1034/j.1601-183x.2003.00024.x
https://doi.org/10.1034/j.1601-183x.2003.00024.x
Publikováno v:
Journal of Neurocytology. 27:707-718
Summary The fine structural features of cultured PC12 cells were investigated after treatment for 1, 3, or 5 days with different concentrations of the vascular form of β- 1–40 (β-AP). PC12 cells treated with β-AP showed time- and concentration-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fc84afe7274b4ac914877ee42c6498
https://doi.org/10.1023/a:1006976400227
https://doi.org/10.1023/a:1006976400227
Autor:
Bowers Lm, Sandra C. Fitzgerald, V. Dunlap, Phillip G. Nelson, D. v. Agoston, Z. Galdzicki, S. I. Rapoport, E. A. Neale
Publikováno v:
Proceedings of the National Academy of Sciences. 94:12644-12648
Trisomy 21 (Down syndrome) is associated with a high incidence of Alzheimer disease and with deficits in cholinergic function in humans. We used the trisomy 16 (Ts16) mouse model for Down syndrome to identify the cellular basis for the cholinergic dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54459a75c0b052b9b5c88cfe9718e620
https://doi.org/10.1073/pnas.94.23.12644
https://doi.org/10.1073/pnas.94.23.12644
Publikováno v:
Biophysical Journal. 73(3):1276-1280
We present a hypothesis for the loss of acetylcholine in Alzheimer's disease that is based on two recent experimental results: that beta-amyloid causes leakage of choline across cell membranes and that decreased production of acetylcholine increases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526aa1e8909a4e480073b57db6a3315f
Publikováno v:
Biochemical Journal. 313:31-33
myo-Inositol and several other polyols were measured in the tissues of the trisomy 16 mouse (animal model of Down's Syndrome; human trisomy 21) and diploid controls. myo-Inositol was found to be selectively elevated in the brain of the trisomy 16 mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634d0a6217b2b66c2ad9f54a1fb11d5c
https://doi.org/10.1042/bj3130031
https://doi.org/10.1042/bj3130031
Autor:
Z, Galdzicki, R J, Siarey
Publikováno v:
Genes, brain, and behavior. 2(3)
Mental retardation in Down's syndrome, human trisomy 21, is characterized by developmental delays, language and memory deficits and other cognitive abnormalities. Neurophysiological and functional information is needed to understand the mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::422880b2e7913249b35bd2b929e84066
https://pubmed.ncbi.nlm.nih.gov/12931790
https://pubmed.ncbi.nlm.nih.gov/12931790
Publikováno v:
Restorative neurology and neuroscience. 12(2-3)
In the trisomy 16 mouse the increased gene dosage of SOD-1 increases H2O2 production that results in increased oxidative stress. We report here that in hippocampal primary cultures, metallothionein (MT)-I/II immunoreactivity was present mainly in gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6966a088b1a96ed56d44d6832b6fe524
https://pubmed.ncbi.nlm.nih.gov/12671302
https://pubmed.ncbi.nlm.nih.gov/12671302
The trisomy 16 (Ts16) mouse is an animal model for human trisomy 21 (Down's syndrome). The gene encoding the NR2A subunit of the NMDA receptor has been localized to mouse chromosome 16. In the present study, western blot analysis revealed a 2.5-fold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2edd41f0cb080405d647c05399d9985f
http://hdl.handle.net/11573/144587
http://hdl.handle.net/11573/144587
