Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Z, Binienda"'
Publikováno v:
Neurotoxicology and Teratology. 18:147-154
To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were treated from about 1 month of gestation until term with either 0 (N = 3), 0.3 (N = 3), 1.0 (N = 3), or escalating doses up to 8.5 (N = 3)
Publikováno v:
Toxicology and Applied Pharmacology. 136:250-259
A physiologically based pharmacokinetic (PBPK) model that describes the kinetics of organic anions by using 2,4-dichlorophenoxyacetic acid (2,4-D) as a representative compound was constructed for the developing rabbit brain at near-term pregnancy (Ge
Autor:
Eduarda Fernandes, Teresa Summavielle, Eduardo Alves, Z. Binienda, Cecília J. Alves, Maria Amélia Tavares, M. de Lourdes Bastos, Félix Carvalho
Publikováno v:
Neuroscience. 158(2)
3,4-Methylenedioximethamphetamine (MDMA, ecstasy) is a worldwide abused stimulant drug, with persistent neurotoxic effects and high prevalence among adolescents. The massive release of 5-HT from pre-synaptic storage vesicles induced by MDMA followed
Publikováno v:
Metabolic brain disease. 14(2)
3-Nitropropionic acid (3-NPA) is a toxin sometimes produced on moldy crops (sugarcane, peanuts, etc.) in amounts sufficient to cause severe neurological disorders when consumed by humans. In vitro, 3-NPA irreversibly inactivates SDH, a Complex II res
Autor:
Z, Binienda, M A, Beaudoin, B T, Thorn, D R, Prapurna, J R, Johnson, C M, Fogle, W, Slikker, S F, Ali
Publikováno v:
Annals of the New York Academy of Sciences. 844
Ibogaine (IBO) is a psychoactive indole alkaloid that has antiaddictive properties. However, treatment with IBO may lead to neurotoxicity, since IBO and its metabolites interact persistently with many neurotransmitter systems. Here, we recorded corti
Autor:
Z, Binienda, R R, Holson, F X, Chen, E, Oriaku, C S, Kim, T J, Flynn, W, Slikker, M G, Paule, R J, Feuers, S A, Ferguson
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 14(4)
The effects of acute perinatal ischemia-hypoxia on fetal liver and brain energy metabolism, fetal brain total free fatty acid concentration and subsequent offspring behavior were investigated in rats. Ischemia-hypoxia was induced at term either by li
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(8)
Publikováno v:
Annals of the New York Academy of Sciences. 723
Publikováno v:
Contemporary topics in laboratory animal science. 33(5)
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 21(2)
The transplacental pharmacokinetics of cocaine were studied in three pregnant rhesus monkeys (Macaca mulatta) at 150-154 days of pregnancy (term approximately 165 days). Animals were dosed intramuscularly with cocaine hydrochloride at 1 mg/kg, supple