Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yvonne Yao"'
Autor:
Carol Thach, Jeff Kucharski, Jingchuan Zhang, Yvonne Yao, Shuangwei Li, Anjali Babbar, Dashyant Dhanak, Rasmus Hansen, Yuan Liu, Yuching Chen, Pingda Ren, Ulf Peters, Yi Liu, Shisheng Li, Ke Yu, Yi Wang, Patrick Parvis Zarrinkar, Xiaohu Deng, Matthew R. Janes, Sarah J. Firdaus, Ata Zarieh, Lian-Sheng Li, Tao Wu, Xin Guo, Jun Feng, Matthew V. Lorenzi, Dana D. Hu-Lowe, Jeffrey H. Chen
Publikováno v:
Cancer Research. 78:929-929
Activating mutations in KRAS have a high prevalence in human cancer. The codon 12 glycine to cysteine missense mutation (KRASG12C) is among the most common KRAS mutations, present in non-small cell lung adenocarcinoma (~15 %), colorectal adenocarcino
Autor:
Jingchuan Zhang, Shuangwei Li, Linda Kessler, Dana D. Hu-Lowe, Yi Wang, Francis Burrows, Lian-Sheng Li, Tao Wu, Jun Feng, Pingda Ren, Ulf Peters, Shisheng Li, Ke Yu, Ata Zarieh, Jeffrey C. Chen, Matt Janes, Yvonne Yao, Yi Liu, Rasmus Hansen, Carol Thach, Jeff Kucharski, Xin Gao
Publikováno v:
Cancer Research. 78:3885-3885
The MAPK pathway is a major driver of malignant progression, particularly in cancers arising from mutations in pathway components, and BRAF and MEK inhibitors have been approved for treatment of BRAF-mutant melanoma. ERK1/2 kinases are the final node
Autor:
Jeff Kucharski, Ulf Peters, Yun O. Long, Shisheng Li, Pingda Ren, Ata Zarieh, Dana D. Hu-Lowe, Ke Yu, Yuan Liu, Tao Wu, Carol Thach, Dirk Brehmer, Tess Ely, Xin Guo, Patrick P. Zarrinkar, Matthew P. Patricelli, Yi Wang, Rasmus Hansen, Dashyant Dhanak, Yi Liu, Jun Feng, Shuangwei Li, Matthew R. Janes, Yuching Chen, Sarah J. Firdaus, Levan Darjania, Linda Kessler, Jeffrey H. Chen, Xiaohu Deng, Yvonne Yao, Anjali Babbar, Matthew V. Lorenzi, Jingchuan Zhang, Lian-Sheng Li
Publikováno v:
Cell. 172:578-589.e17
KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its act
Autor:
Shuangwei Li, Jingchuan Zhang, Linda Kessler, Ata Zarieh, Pingda Ren, Yi Wang, Carol Thach, Tao Wu, Yvonne Yao, Lian-Sheng Li, Yi Liu, Xin Gao, Levan Darjania, Jeffrey H. Chen, Francis Burrows, Ke Yu, Dana D. Hu-Lowe, Rasmus Hansen
Publikováno v:
Cancer Research. 77:5168-5168
The RAS/RAF/MEK pathway is a major driver of malignant progression, particularly in cancers arising from mutations in RAS, BRAF and NF1. Although both BRAF and MEK inhibitors have been approved for treatment of melanoma, their clinical activity is co
Autor:
Jingchuan Zhang, Patrick P. Zarrinkar, Ulf Peters, Levan Darjania, Shisheng Li, Rasmus Hansen, Ke Yu, Ata Zarieh, Shuangwei Li, Dana D. Hu-Lowe, Jolanta Grembecka, Pingda Ren, Linda Kessler, Szymon Klossowski, Duxin Sun, Francis Burrows, Yvonne Yao, Tess Ely, Lian-Sheng Li, Yi Liu, Yuan Liu, Katarzyna Kempińska, Hongzhi Miao, Jeff Kucharski, Tao Wu, Trupta Purohit, Bo Wen, Tomasz Cierpicki, Jun Feng, Brian M. Linhares, Yi Wang
Publikováno v:
Cancer Research. 77:5077-5077
Patients with MLL-rearranged leukemia typically have a poor prognosis. With chemotherapy and stem cell transplantation as current standard of care, the 5-year survival rate is estimated to be only about 35%. As the leukemogenic activity of MLL fusion
Autor:
Sally A. Camper, Fritz M. Rottman, Dennis N. Luck, Robert H. Lyons, Ray G. Goodwin, Richard P. Woychik, Yvonne Yao
Publikováno v:
DNA. 3:237-249
The gene coding for bovine prolactin was shown to exist as a single copy per haploid genome. Three restriction fragment polymorphisms were detected in the prolactin gene by Southern blot analysis of DNA obtained from the semen of pedigreed bulls repr
Publikováno v:
Journal of Biological Chemistry. 260:12246-12251
A 1-kilobase DNA fragment containing the promoter of the bovine prolactin gene was fused to the chloramphenicol acetyltransferase gene and the activity of the promoter was assayed by transfection of the fusion gene into COS-1, HeLa, and GH3 cells. Tr
Autor:
R. Albers, S. Horowitz, Yvonne Yao, Fritz M. Rottman, Timothy W. Nilsen, Prema Narayan, Raymond G. Goodwin, Sally A. Camper, Deborah G. Ayers, Patricia A. Maroney
Publikováno v:
Biological Methylation and Drug Design ISBN: 9781461293989
Methylation of cellular and viral mRNA is a common post-transcriptional event whose function is not well understood. Although a role for 5′ terminal methylated cap structures in translation and mRNA stability has been demonstrated (Both et al., 197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df4b575434877e7872fd6961540a2995
https://doi.org/10.1007/978-1-4612-5012-8_16
https://doi.org/10.1007/978-1-4612-5012-8_16
Autor:
Yvonne Yao, Robert K. Hampson, Sally A. Camper, Dennis Sakai, Robert H. Lyons, Richard P. Woychik, Edward C. Goodwin, Fritz M. Rottman
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468452112
Prolactin and growth hormone are members of a gene family which has been extensively studied during the past several years (Miller and Eberhardt, 1983). Along with the gonadotropins, the members of this gene family are primarily expressed in the ante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71da3fbe8810dbafefe622a473a45694
https://doi.org/10.1007/978-1-4684-5209-9_13
https://doi.org/10.1007/978-1-4684-5209-9_13