Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Yvonne Y. Chen"'
Autor:
Eugenia Zah, Eunwoo Nam, Vinya Bhuvan, Uyen Tran, Brenda Y. Ji, Stanley B. Gosliner, Xiuli Wang, Christine E. Brown, Yvonne Y. Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associ
Externí odkaz:
https://doaj.org/article/ec2f088f8b5544bbb62387a290932f01
Autor:
Yvonne Y. Chen, Lyndsey Aponik-Gremillion, Eleonora Bartoli, Daniel Yoshor, Sameer A. Sheth, Brett L. Foster
Publikováno v:
Cell Reports, Vol 35, Iss 13, Pp 109304- (2021)
Summary: High-frequency activity bursts in the hippocampus, known as ripples, are thought to support memory consolidation during “offline” states, such as sleep. Recently, human hippocampal ripples have been observed during “online” episodic
Externí odkaz:
https://doaj.org/article/48864eb73fda47819527d907ce37dedf
Autor:
Jayapriya Jayaraman, Michael P. Mellody, Andrew J. Hou, Ruchi P. Desai, Audrey W. Fung, An Huynh Thuy Pham, Yvonne Y. Chen, Weian Zhao
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102931- (2020)
Chimeric antigen receptor (CAR) T cells use re-engineered cell surface receptors to specifically bind to and lyse oncogenic cells. Two clinically approved CAR-T–cell therapies have significant clinical efficacy in treating CD19-positive B cell canc
Externí odkaz:
https://doaj.org/article/c84096dfa04e47f780401fcebaf730ae
Autor:
Yvonne Y. Chen, Demetri M. Nicolaou, Yunfeng Ding, Anya S. Alag, Neha Iyer, Amanda Shafer, Emma Salvestrini, Xiangzhi Meng, Mobina Khericha, Laurence C. Chen, Ximin Chen
Differential chromatin accessible region and FPKM values from ATAC-seq on T cells harvested from tumor-bearing mice (Fig. 4E).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e83c0cd03957dc56de415dea14ab4a7
https://doi.org/10.1158/2326-6066.22546266
https://doi.org/10.1158/2326-6066.22546266
Autor:
Yvonne Y. Chen, Antoni Ribas, John M. Timmerman, Gary J. Schiller, Caspian Oliai, Patricia A. Young, Sven de Vos, Monica Mead, Karla Nawaly, Jonathan Said, Martin S. Allen-Auerbach, Melanie Ayala Ceja, Amr Almaktari, Stanley B. Gosliner, Beata Berent-Maoz, Thomas Schweppe, Mobina Khericha, Caitlin Harris, Mobina Roshandell, Jia Ming Chen, Jacqueline Trent, Jacob Naparstek, Sanaz N. Ghafouri, Brenda Ji, Christopher M. Walthers, Sarah M. Larson
CART19/20 cell product characteristics. (A) % CD4+ among total T cells and CAR-expressing T cells. (B) Comparison of T-cell subtype frequency among CD4+ vs. CD8+ T cells in cryopreserved CART19/20 cell products. Te/exh: effector/exhausted T cells, CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e23adcca8d5d92e2da936e75c073574
https://doi.org/10.1158/2159-8290.22542543
https://doi.org/10.1158/2159-8290.22542543
Autor:
Yvonne Y. Chen, Demetri M. Nicolaou, Yunfeng Ding, Anya S. Alag, Neha Iyer, Amanda Shafer, Emma Salvestrini, Xiangzhi Meng, Mobina Khericha, Laurence C. Chen, Ximin Chen
Figures S1 to S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19b9b18a8032cd56ca32e2117cbaf0f0
https://doi.org/10.1158/2326-6066.22546260
https://doi.org/10.1158/2326-6066.22546260
Autor:
Yvonne Y. Chen, Antoni Ribas, John M. Timmerman, Gary J. Schiller, Caspian Oliai, Patricia A. Young, Sven de Vos, Monica Mead, Karla Nawaly, Jonathan Said, Martin S. Allen-Auerbach, Melanie Ayala Ceja, Amr Almaktari, Stanley B. Gosliner, Beata Berent-Maoz, Thomas Schweppe, Mobina Khericha, Caitlin Harris, Mobina Roshandell, Jia Ming Chen, Jacqueline Trent, Jacob Naparstek, Sanaz N. Ghafouri, Brenda Ji, Christopher M. Walthers, Sarah M. Larson
To address antigen escape and loss of T-cell functionality, we report a phase I clinical trial (NCT04007029) evaluating autologous naive and memory T (TN/MEM) cells engineered to express a bispecific anti-CD19/CD20 chimeric antigen receptor (CAR; CAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050a671732fa83e533f6d56dd43cca46
https://doi.org/10.1158/2159-8290.c.6549963
https://doi.org/10.1158/2159-8290.c.6549963
Autor:
Yvonne Y. Chen, Antoni Ribas, John M. Timmerman, Gary J. Schiller, Caspian Oliai, Patricia A. Young, Sven de Vos, Monica Mead, Karla Nawaly, Jonathan Said, Martin S. Allen-Auerbach, Melanie Ayala Ceja, Amr Almaktari, Stanley B. Gosliner, Beata Berent-Maoz, Thomas Schweppe, Mobina Khericha, Caitlin Harris, Mobina Roshandell, Jia Ming Chen, Jacqueline Trent, Jacob Naparstek, Sanaz N. Ghafouri, Brenda Ji, Christopher M. Walthers, Sarah M. Larson
Representativeness of study participants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5e747491d7940bb0d582091c2fa708
https://doi.org/10.1158/2159-8290.22542522
https://doi.org/10.1158/2159-8290.22542522
Autor:
Yvonne Y. Chen, Demetri M. Nicolaou, Yunfeng Ding, Anya S. Alag, Neha Iyer, Amanda Shafer, Emma Salvestrini, Xiangzhi Meng, Mobina Khericha, Laurence C. Chen, Ximin Chen
Chimeric antigen receptors (CAR) are fusion proteins whose functional domains are often connected in a plug-and-play manner to generate multiple CAR variants. However, CARs with highly similar sequences can exhibit dramatic differences in function. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c19a561c65b7170d8e50633b44bed81
https://doi.org/10.1158/2326-6066.c.6551133
https://doi.org/10.1158/2326-6066.c.6551133
Autor:
Aliya Lakhani, Ximin Chen, Laurence C. Chen, Mobina Khericha, Yvonne Y. Chen, Junyoung O. Park
Publikováno v:
bioRxiv
Metabolism is an indispensable part of T-cell proliferation, activation, and exhaustion, yet the metabolism of chimeric antigen receptor (CAR)-T cells remains incompletely understood. CARs are comprised of extracellular domains that determine cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d871559f49aa23394360646f6b3eafce
https://doi.org/10.1101/2023.04.03.533021
https://doi.org/10.1101/2023.04.03.533021