Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Yvonne Y C Yeap"'
Autor:
Dan Xu, Minghui Yao, Yaqing Wang, Ling Yuan, Joerg D Hoeck, Jingwen Yu, Liang Liu, Yvonne Y C Yeap, Weiya Zhang, Feng Zhang, Yinghang Feng, Tiantian Ma, Yujie Wang, Dominic C H Ng, Xiaoyin Niu, Bing Su, Axel Behrens, Zhiheng Xu
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e2006613 (2018)
Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated and hence controls neurogenes
Externí odkaz:
https://doaj.org/article/10394521c613474994f3be209b267415
Autor:
Belal Shohayeb, Zhe Wei, Kum Kum Khanna, Amanda L. Bain, Josephine Bowles, Uda Ho, Dominic C.H. Ng, Yvonne Y C Yeap, Chun-Wei Allen Feng, Melissa E. Reichelt, Hayden Homer
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
WDR62 is a scaffold protein involved in centriole duplication and spindle assembly during mitosis. Mutations in WDR62 can cause primary microcephaly and premature ovarian insufficiency. We have generated a genetrap mouse model deficient in WDR62 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f9ba191333efb8904c2efa91256f19
https://pubmed.ncbi.nlm.nih.gov/34059773
https://pubmed.ncbi.nlm.nih.gov/34059773
Autor:
Yvonne Y C Yeap, Dominic C.H. Ng, Uda Ho, Zhiheng Xu, Michael Piper, Robert G. Parton, Belal Shohayeb, S. Sean Millard
Publikováno v:
Human molecular genetics. 29(2)
WDR62 mutations that result in protein loss, truncation or single amino-acid substitutions are causative for human microcephaly, indicating critical roles in cell expansion required for brain development. WDR62 missense mutations that retain protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d720a364d3d2f95dd08b9173d24dea
https://pubmed.ncbi.nlm.nih.gov/31816041
https://pubmed.ncbi.nlm.nih.gov/31816041
Autor:
Melissa E. Reichelt, Yvonne Y C Yeap, Dominic K. Richards, Grant McLachlan, Phillip L. van der Peet, Owen L. Woodman, Dominic C.H. Ng, Spencer J. Williams
Publikováno v:
Circulation Research. 123
3’,4’-dihydroxyflavonol (DiOHF) is a synthetic flavonol in a class of phytochemicals known as flavonoids can have beneficial biological properties. Previous studies revealed that intravenous administration of DiOHF immediately preceding myocardia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a582a85af6ecf5b90c0bc3eecce3b41
https://doi.org/10.1161/res.123.suppl_1.426
https://doi.org/10.1161/res.123.suppl_1.426
Autor:
Clive N. May, Nicholas R. Lim, Owen L. Woodman, Colleen J. Thomas, Yvonne Y C Yeap, Alphious Kedikaetswe, Dominic C.H. Ng
Publikováno v:
European Journal of Pharmacology. 758:53-59
The novel pro-drug of 3'4'-dihydroxyflavonol, NP202, potently reduces myocardial infarct size resulting from ischemia-reperfusion (I/R) through mechanisms that remain to be fully defined. In this study, we investigated whether cardioprotection induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a0ea2b42434af8d61dce63d5e53ea6
https://doi.org/10.1016/j.ejphar.2015.03.054
https://doi.org/10.1016/j.ejphar.2015.03.054
Publikováno v:
Biochemical and Biophysical Research Communications. 446:248-254
The stathmin (STMN) family of tubulin-binding phosphoproteins are critical regulators of interphase microtubule dynamics and organization in a broad range of cellular processes. c-Jun N-terminal kinase (JNK) signalling to STMN family proteins has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478bb74f4293c5a21dd6fc0440ea5b84
https://doi.org/10.1016/j.bbrc.2014.02.101
https://doi.org/10.1016/j.bbrc.2014.02.101
Publikováno v:
Journal of Biological Chemistry. 289:2157-2169
Dynamic microtubule changes after a cell stress challenge are required for cell survival and adaptation. Stathmin (STMN), a cytoplasmic microtubule-destabilizing phosphoprotein, regulates interphase microtubules during cell stress, but the signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a41c8b8d7fd8b063e05d2cf17461e6
https://doi.org/10.1074/jbc.m113.470682
https://doi.org/10.1074/jbc.m113.470682
Autor:
Minghui Yao, Yaqing Wang, Liang Liu, Yvonne Y C Yeap, Zhiheng Xu, Weiya Zhang, Yujie Wang, Axel Behrens, Yinghang Feng, Xiaoyin Niu, Jingwen Yu, Tiantian Ma, Feng Zhang, Dan Xu, Bing Su, Joerg D. Hoeck, Ling Yuan, Dominic C.H. Ng
Publikováno v:
PLoS Biology, Vol 16, Iss 12, p e2006613 (2018)
PLoS Biology
PLoS Biology
Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated and hence controls neurogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::597fab7719b6118f52cae1f9686738ac
https://doi.org/10.1371/journal.pbio.2006613
https://doi.org/10.1371/journal.pbio.2006613
Autor:
Yvonne Y C Yeap, Nicholas R. Lim, Marie A. Bogoyevitch, Ching-Seng Ang, Nicholas A. Williamson, Dominic C.H. Ng, Leonie M. Quinn
Publikováno v:
Cell cycle (Georgetown, Tex.). 15(3)
Mitotic spindle organization is regulated by centrosomal kinases that potentiate recruitment of spindle-associated proteins required for normal mitotic progress including the microcephaly protein WD40-repeat protein 62 (WDR62). WDR62 functions underl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a76ed9f6b8e63cf0af6ef2139d76f5d
https://pubmed.ncbi.nlm.nih.gov/27110649
https://pubmed.ncbi.nlm.nih.gov/27110649
Autor:
Ivan Hong Wee Ng, Dominic C.H. Ng, Christopher Semsarian, Yvonne Y C Yeap, Tatiana Tsoutsman, Julie R. McMullen, Bahareh Badrian, Marie A. Bogoyevitch
Publikováno v:
Journal of Biological Chemistry. 286:1576-1587
Excessive proliferation and stabilization of the microtubule (MT) array in cardiac myocytes can accompany pathological cardiac hypertrophy, but the molecular control of these changes remains poorly characterized. In this study, we examined MT stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc1da898845d4f77b09310c6a98b3a
https://doi.org/10.1074/jbc.m110.128157
https://doi.org/10.1074/jbc.m110.128157