Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yvonne Van Gessel"'
Autor:
Khin Saw Aye Myint, Anja Kipar, Richard G Jarman, Robert V Gibbons, Guey Chuen Perng, Brian Flanagan, Duangrat Mongkolsirichaikul, Yvonne Van Gessel, Tom Solomon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e2980 (2014)
Japanese encephalitis (JE) is a major cause of mortality and morbidity for which there is no treatment. In addition to direct viral cytopathology, the inflammatory response is postulated to contribute to the pathogenesis. Our goal was to determine th
Externí odkaz:
https://doaj.org/article/d6326f7282674c41a31312bd2dfd975d
Autor:
Amber M. Smith, Stephan Chalon, Ryan N Heine, Tracy B Stewart, James S. McCarthy, Robbin Christensen, Lidiya Bebrevska, Elizabeth John, Ronald H. Dallas, Fabian Gusovsky, John C. Panetta, Yvonne Van Gessel, Kristen Branum, Branko Mitasev, R. Kiplin Guy, Aditya H. Gaur, Shelley Ost, Burgess B. Freeman, John Woodford, Nehali Patel, Li Tang, Jörg J. Möhrle, Patricia M. Flynn, Julie Richardson
Publikováno v:
The Lancet. Infectious diseases. 20(8)
Summary Background (+)-SJ000557733 (SJ733) is a novel, orally bioavailable inhibitor of Plasmodium falciparum ATP4. In this first-in-human and induced blood-stage malaria phase 1a/b trial, we investigated the safety, tolerability, pharmacokinetics, a
Autor:
Daniel E. Neafsey, Dyann F. Wirth, Jon Clardy, Arvind Sharma, Ping S. Lui, Anne-Marie Zeeman, Sean Eckley, Yvonne Van Gessel, Mathias Wawer, Matthias Marti, Elizabeth A. Winzeler, Elamaran Meibalan, Nobutaka Kato, Benito Munoz, Emily R. Derbyshire, Stuart L. Schreiber, Marshall L. Morningstar, Jeremy R. Duvall, Clemens H. M. Kocken, Eli L. Moss, Bennett C. Meier, Joshua A. Bittker, Vicky M. Avery, Manmohan Sharma, John E. Burke, Eamon Comer, Jacob A. McPhail, Maurice A. Itoe, Jessica Bastien, Nicolas M. B. Brancucci, Branko Mitasev, David Clarke, Timothy A. Lewis, Victoria C. Corey, Sandra Duffy, Tomoyo Sakata-Kato, Fabian Gusovsky, Sandra March, Takashi Yoshinaga, Gillian L. Dornan, Flaminia Catteruccia, Morgane Sayes, Emily Lund, Christina Scherer, Sangeeta N. Bhatia, Michael Foley, Amit Sharma, Amanda K. Lukens, Paul A. Clemons, Koen J. Dechering, Karin M. J. Koolen, Micah Maetani
Publikováno v:
Nature
Antimalarial drugs have thus far been chiefly derived from two sources-natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a diverse collection
Autor:
Larry A. Walker, Rajnish Sahu, Gregory A. Reichard, H. M. T. Bandara Herath, N. P. Dhammika Nanayakkara, Babu L. Tekwani, Frank R. Fronczek, Anchalee Tungtaeng, James D. McChesney, Paul C. Baresel, Kristina S. Wickham, Yvonne Van Gessel, Victor Melendez, Rosemary Rochford, Marilyn S. Bartlett, Colin Ohrt, Montip Gettayacamin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4737-4744
Hematotoxicity in individuals genetically deficient in glucose-6-phosphate dehydrogenase (G6PD) activity is the major limitation of primaquine (PQ), the only antimalarial drug in clinical use for treatment of relapsing Plasmodium vivax malaria. PQ is
Autor:
Robert Putnak, Martin Spruth, Shailesh Dewasthaly, Montip Gettayacamin, Alessandra Formica, Christoph Klade, Yvonne Van Gessel, Anchalee Tungtaeng, Somporn Krasaesub, Bruno Cena
Publikováno v:
Vaccine. 29:5925-5931
Immune sera from volunteers vaccinated in a blinded Phase 3 clinical trial with JE-VAX(®) and a new Japanese encephalitis virus (JEV) vaccine (IC51 or IXIARO), were tested for the ability to protect mice against lethal JEV challenge. Sera from IXIAR
Autor:
David Hutto, Yoshihiko Kotake, Zhihong Chen, Yimin Jiang, Krista Condon, Yvonne Van Gessel, Kuan-Chun Huang, Sandeep Akare, Sean Eckley
Publikováno v:
The FASEB Journal. 29
Autor:
Douglas K. Tadaki, Kelvin P. Lee, Yvonne Van Gessel, Mark E. Lasbury, P J Perrin, Richard L. Beswick, Pamela J. Durant, Suchismita Chattopadhyay, Roxanne E. Baumgartner, Chao-Hung Lee
Publikováno v:
Microbial Pathogenesis. 33:193-201
Pneumocystis carinii pneumonia (PCP) is a frequent and serious opportunistic infection in immunocompromized patients. Although the pathogenesis of PCP-mediated lung injury is poorly understood, a central involvement of host inflammatory responses has
Autor:
Richard G. Jarman, Tom Solomon, Anja Kipar, Duangrat Mongkolsirichaikul, Yvonne Van Gessel, Khin Saw Aye Myint, Robert V. Gibbons, Guey Chuen Perng, Brian F. Flanagan
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e2980 (2014)
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e2980 (2014)
Background Japanese encephalitis (JE) is a major cause of mortality and morbidity for which there is no treatment. In addition to direct viral cytopathology, the inflammatory response is postulated to contribute to the pathogenesis. Our goal was to d
Autor:
Yoshikazu Taketa, Sandeep Akare, Jiro Sonoda, Kazuhiro Hayakawa, Kyoko Nakano-Ito, David Hutto, Kazuo Tsukidate, Yasuhiro Fujikawa, Satoru Hosokawa, Akira Inomata, Yvonne Van Gessel, Etsuko Ohta
Publikováno v:
Toxicologic pathology. 42(8)
Vascular endothelial growth factor (VEGF) receptor tyrosine kinase (RTK) inhibitors are reported to cause reversible mucosal hyperplasia (adenosis) in the duodenum of rats; however, the pathogenesis is not fully elucidated. Using lenvatinib, a VEGF R
Autor:
Anthony J. Marshall, Laura Rosa Brunet, Yvonne van Gessel, Ana Alcaraz, Susan K. Bliss, Edward J. Pearce, Eric Y. Denkers
Publikováno v:
The Journal of Immunology. 163:2089-2097
To address the question of how the murine host responds to a prototypic type 1 cytokine inducer while concurrently undergoing a helminth-induced type 2 cytokine response, C57BL/6 strain animals with patent schistosomiasis mansoni were orally infected