Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Yvonne Scherbantin"'
Autor:
Yvonne Scherbantin, Gerd Bader, thomas Fett, Harald Weinstabl, Sophie Mitzner, Tuncay Ciftci, Bernhard Wolkerstorfer, Jens Bruchhaus, Xiaobing Lv, Dongyang Li, Bernadette Sharps, Daniela Haering, Heribert Arnhof, Nikolai Mischerikow, Geraldine Garavel, Andreas Schrenk, Joerg Rinnenthal, Roland Kousek, Thomas Gerstberger, Guido Scholz, Stephan Karl Zahn, Paola Martinelli, Jens Quant, Renate Schnitzer, Andreas Zoephel, Darryl B. McConnell, Moriz Mayer, Dirk Kessler, Xuechun Zhang, Michelle Burkard, Mark Pearson, Karin S. Hofbauer, Alicia Du, Matthias Treu, Christoph Harrer, Yali Li, Fabio Savarese, Klaus Rumpel, Biljana Peric-Simov, Georg Dahmann, Wolfgang Sommergruber, Peter Ettmayer
Publikováno v:
Journal of Medicinal Chemistry. 62:7976-7997
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction. Herein, we r
Autor:
Andreas Schrenk, Daniela Häring, Silke Fischer, Stefan Kornigg, Alex G. Waterson, Andreas Mantoulidis, Manfred Koegl, Markus Zeeb, Thomas Gerstberger, Mark Pearson, Wolfgang Hela, Andreas Zoephel, Darryl B. McConnell, Michael Gmachl, Bernadette Sharps, Jale Karolyi-Oezguer, Johann Hoffmann, Franziska Moser, Jason Phan, Teresa Gmaschitz, David Covini, Bernhard Wolkerstorfer, Qi Sun, Lyne Lamarre, Gabriella Siszler, Renate Schnitzer, Moriz Mayer, Dirk Kessler, Katharina Schipany, Petr Knesl, Christian Salamon, Peter Greb, Stephen W. Fesik, Andreas Gollner, Yvonne Scherbantin, Silvia Munico-Martinez, Craig M. Goodwin, Roland Kousek, Jörg Rinnenthal, Jiqing Sai, Christoph Peinsipp, Laetitia J. Martin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Despite decades of research, no approved drugs have been discovered for KRAS. Recently, a pocket occurring on the surface of the active and inactive form of KRAS was found, but, due to its comparatively shallow, polar nature, this pocket