Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Yvonne R Freund"'
Autor:
Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 1, p e0007957 (2020)
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal-adult worm killing-drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that ta
Externí odkaz:
https://doaj.org/article/dec6d4c0192a4b7f912f2690a17c0fac
Autor:
Andrés Palencia, Alexandre Bougdour, Marie‐Pierre Brenier‐Pinchart, Bastien Touquet, Rose‐Laurence Bertini, Cristina Sensi, Gabrielle Gay, Julien Vollaire, Véronique Josserand, Eric Easom, Yvonne R Freund, Hervé Pelloux, Philip J Rosenthal, Stephen Cusack, Mohamed‐Ali Hakimi
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 3, Pp 385-394 (2017)
Abstract Toxoplasma gondii is an important food and waterborne pathogen causing toxoplasmosis, a potentially severe disease in immunocompromised or congenitally infected humans. Available therapeutic agents are limited by suboptimal efficacy and freq
Externí odkaz:
https://doaj.org/article/96892dd7fa464077a75b0e590d1fd393
Autor:
Ning Zhang, Martin Zoltner, Ka-Fai Leung, Paul Scullion, Sebastian Hutchinson, Ricardo C Del Pino, Isabel M Vincent, Yong-Kang Zhang, Yvonne R Freund, Michael R K Alley, Robert T Jacobs, Kevin D Read, Michael P Barrett, David Horn, Mark C Field
Publikováno v:
PLoS Pathogens, Vol 14, Iss 2, p e1006850 (2018)
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However
Externí odkaz:
https://doaj.org/article/15b9266be10f461686b0efc0aad70326
Autor:
Tsutomu Akama, Yvonne R. Freund, Pamela W. Berry, David S. Carter, Eric E. Easom, Kurt Jarnagin, Christopher S. Lunde, Jacob J. Plattner, Fernando Rock, Rianna Stefanakis, Chelsea Fischer, Christina A. Bulman, Kee Chong Lim, Brian M. Suzuki, Nancy Tricoche, Abdelmoneim Mansour, Utami DiCosty, Scott McCall, Ben Carson, John W. McCall, James McKerrow, Marc P. Hübner, Sabine Specht, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari, Robert T. Jacobs
Publikováno v:
ACS Infectious Diseases
A series of benzimidazole–benzoxaborole hybrid molecules linked via an amide linker are described that exhibit good in vitro activity against Onchocerca volvulus, a filarial nematode responsible for the disease onchocerciasis, also known as river b
Autor:
Tsutomu, Akama, Yong-Kang, Zhang, Yvonne R, Freund, Pamela, Berry, Joanne, Lee, Eric E, Easom, Robert T, Jacobs, Jacob J, Plattner, Michael J, Witty, Rosemary, Peter, Tim G, Rowan, Kirsten, Gillingwater, Reto, Brun, Bakela, Nare, Luke, Mercer, Musheng, Xu, Jiangong, Wang, Hao, Liang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolen
Novel l-valinate amide benzoxaboroles and analogues were designed and synthesized for a structure-activity-relationship (SAR) investigation to optimize the growth inhibitory activity against Trypanosoma congolense (T. congolen
Autor:
Thomas S. Kilduff, Barrett P Eynon, Stephen R. Morairty, Linda Dousman, A. Apte-Deshpande, Yvonne R. Freund, Akira Terao
Publikováno v:
Journal of Neuroimmunology. 132:99-112
Using GeneChipsR, basal and lipopolysaccharide (LPS)-induced gene expression was examined in the hippocampus of 3-, 12-, 18- and 24-month-old male C57BL/6 mice to identify genes whose altered expression could influence hippocampal function in advance
Autor:
Moire R. Creek, Jack E. Dabbs, Sandra J. Phillips, Charles A. Tyson, Yvonne R. Freund, James T. MacGregor
Publikováno v:
Toxicology and Applied Pharmacology. 181:16-26
Pyrimethamine (Pyr) is commonly used for treatment of toxoplasmic encephalitis in AIDS patients; however, in two clinical studies, an increased number of deaths were observed when Pyr was coadministered with zidovudine (ZDV). The BALB/c mouse was cho
Publikováno v:
Toxicological Sciences. 55:335-342
Trimethoprim-sulfamethoxazole (TMP-SMX), commonly used for prophylaxis of Pneumocystis carinii pneumonia (PCP) in AIDS patients, often produces a high incidence of treatment-limiting reactions. We investigated the effect of oral administration of TMP
Autor:
Jon C. Mirsalis, James W. Hodge, Leslie A. Hokama, Joyce Brune, David G. Fairchild, Jeffrey Schlom, Janice Schindler-Horvat, Charles A. Tyson, Yvonne R. Freund, Judy Kantor, Susan J. Donohue, Joseph E. Tomaszewski
Publikováno v:
International Journal of Cancer. 85:508-517
B7-1 is a co-stimulatory molecule that provides a second signal for T-cell activation. Several studies have demonstrated that vaccination with a vector containing genes encoding B7-1 and an antigen appears to be efficacious at promoting immune respon
Publikováno v:
Toxicological Sciences. 42:91-98