Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yvonne Puplampu-Dove"'
Autor:
Yvonne Puplampu-Dove, Tal Gefen, Anugraha Rajagopalan, Darija Muheramagic, Brett Schrand, Eli Gilboa
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
TGFβ secreted by tumor cells and/or tumor infiltrating stromal cells is a key mediator of tumor growth and immune suppression at the tumor site. Nonetheless, clinical trials in cancer patients targeting the TGFβ pathway exhibited at best a modest t
Externí odkaz:
https://doaj.org/article/9458eae395db4704bee53da5840f006f
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Table 1Suppl. Table 1 related to materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c867539694432660b7dd69219ed965
https://doi.org/10.1158/2326-6066.22544859.v1
https://doi.org/10.1158/2326-6066.22544859.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Supplementary Figures S1-S7Supplementary Figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10cee7b46fd70653a2fd06bbbb1e9efe
https://doi.org/10.1158/2326-6066.22544862.v1
https://doi.org/10.1158/2326-6066.22544862.v1
Autor:
Gianluca Carlesso, Darren J. Schofield, Ronald Herbst, Geetha K. Bhat, Jeffrey M. Riggs, Yvonne Puplampu-Dove, Zenon Zenonos, Gareth Browne, Andrew Garcia, Tamer I. Mahmoud, Hormas Ghadially, Des C. Jones, Taeil Kim, Madhu Ramaswamy
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec9ec374bbda9dffe535a040c2c2b71
https://doi.org/10.1158/2326-6066.c.6550767.v1
https://doi.org/10.1158/2326-6066.c.6550767.v1
Publikováno v:
JAMA. 329:1404
This study examines the dissemination of trial results by data source (ie, ClinicalTrials.gov and PubMed) and funder type (ie, industry and nonindustry).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fae7c54dc76057ecb060ff9f113bbaff
https://doi.org/10.1001/jama.2023.2351
https://doi.org/10.1001/jama.2023.2351
Autor:
Madhu Ramaswamy, Taeil Kim, Des C. Jones, Hormas Ghadially, Tamer I. Mahmoud, Andrew Garcia, Gareth Browne, Zenon Zenonos, Yvonne Puplampu-Dove, Jeffrey M. Riggs, Geetha K. Bhat, Ronald Herbst, Darren J. Schofield, Gianluca Carlesso
Publikováno v:
Cancer immunology research. 10(2)
Checkpoint blockade therapies targeting PD-1/PD-L1 and CTLA-4 are clinically successful but also evoke adverse events due to systemic T-cell activation. We engineered a bispecific, mAb targeting CD28 homolog (CD28H), a newly identified B7 family rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c36032091d7d1ccc89453eacc2b535
https://pubmed.ncbi.nlm.nih.gov/34937728
https://pubmed.ncbi.nlm.nih.gov/34937728
Autor:
Anugraha Rajagopalan, Yvonne Puplampu-Dove, Darija Muheramagic, Tal Gefen, Brett Schrand, Eli Gilboa
Publikováno v:
OncoImmunology, Vol 7, Iss 4 (2018)
TGFβ secreted by tumor cells and/or tumor infiltrating stromal cells is a key mediator of tumor growth and immune suppression at the tumor site. Nonetheless, clinical trials in cancer patients targeting the TGFβ pathway exhibited at best a modest t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800809127916f1dc24fe30c2b3f102ac
https://europepmc.org/articles/PMC5889204/
https://europepmc.org/articles/PMC5889204/
T cell immunoglobulin-3 (TIM-3) is a negative regulator of interferon-γ (IFN-γ) secreting CD4+ T cells and CD8+ T cytotoxic cells. Recent studies have highlighted the role of TIM-3 as an important mediator of CD8+ T cell exhaustion in the setting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed13bb24dac1aaf7fc64da920ea5425
https://europepmc.org/articles/PMC5628791/
https://europepmc.org/articles/PMC5628791/
Immune responses elicited against cancer using existing therapies such as vaccines or immune stimulatory antibodies are often not curative. One way to potentiate antitumor immunity is to enhance the long-term persistence of anti-tumor CD8+ T cells. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::969ca95161ac02f6185a962ef8d9a2bd
https://europepmc.org/articles/PMC5363184/
https://europepmc.org/articles/PMC5363184/
Publikováno v:
Cancer Research. 75:3147-3147
CD8 memory T cells play a crucial role in controlling chronic infections and certain malignancies. It is possible to expand the population redirecting early-activated T-cells toward memory differentiation by altering intracellular signaling of mTORC1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738f7bb09bbca7e7af3ac4cdb5731dc6
https://doi.org/10.1158/1538-7445.am2015-3147
https://doi.org/10.1158/1538-7445.am2015-3147