Short-Chain Fatty Acids Differentially Affect Intracellular Lipolysis in a Human White Adipocyte Model

Autor: Johan W. E. Jocken, Manuel A. González Hernández, Nicole T. H. Hoebers, Christina M. van der Beek, Yvonne P. G. Essers, Ellen E. Blaak, Emanuel E. Canfora

Publikováno v: Frontiers in Endocrinology, Vol 8 (2018)

Background and aimsGut-derived short-chain fatty acids (SCFA), formed by microbial fermentation of dietary fibers, are believed to be involved in the etiology of obesity and diabetes. Previous data from our group showed that colonic infusions of phys

Externí odkaz: https://doaj.org/article/bbf9d3962d4343a4ad5e7ab5f3e6f105

Mild intermittent hypoxia exposure induces metabolic and molecular adaptations in men with obesity

Autor: Kasper M.A. Rouschop, Lars M.M. Vliex, Yvonne P. G. Essers, Gijs H. Goossens, Henrike Sell, Ellen E. Blaak, Paul F.M. Schoffelen, Joey S J Smeets, M. A. A. Vogel, Joris Hoeks, Johan W. E. Jocken, Nicole Hoebers, Rens L. J. van Meijel, Sander Kersten

Publikováno v: Molecular Metabolism, 53:101287. Elsevier
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101287-(2021)
Molecular Metabolism 53 (2021)
Molecular Metabolism, 53

Objective Recent studies suggest that hypoxia exposure may improve glucose homeostasis, but well-controlled human studies are lacking. We hypothesized that mild intermittent hypoxia (MIH) exposure decreases tissue oxygen partial pressure (pO2) and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc2a5bc27f6862cef92293a521b0fee
https://doi.org/10.1016/j.molmet.2021.101287

Contribution of lipase deficiency to mitochondrial dysfunction and insulin resistance in hMADS adipocytes

Autor: Gijs H. Goossens, Ellen E. Blaak, Yvonne P. G. Essers, Herman E. Popeijus, Nicole Hoebers, Johan W. E. Jocken

Publikováno v: International Journal of Obesity, 40(3), 507-513. Nature Publishing Group

BACKGROUND/OBJECTIVES: Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are key enzymes involved in intracellular lipid catabolism. We have previously shown decreased expression and activity of these lipases in adipose tissue of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d13d605c4d64ba10779d209b2f91db
https://doi.org/10.1038/ijo.2015.211

Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation

Autor: Nicolas Venteclef, Ellen E. Blaak, Jack P.M. Cleutjens, Ellen Konings, Merima Cajlakovic, Gijs H. Goossens, Alessandro Bizzarri, Volker Ribitsch, Yvonne P. G. Essers, Johan W. E. Jocken, Karine Clément

Publikováno v: Circulation, 124(1), 67-76. LIPPINCOTT WILLIAMS & WILKINS

Background— Adipose tissue (AT) dysfunction in obesity contributes to chronic, low-grade inflammation that predisposes to type 2 diabetes mellitus and cardiovascular disease. Recent in vitro studies suggest that AT hypoxia may induce inflammation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1001a5f37bc97fa503fb9f7dfb4eb881
https://doi.org/10.1161/circulationaha.111.027813

Uterine Artery Remodeling in Pseudopregnancy Is Comparable to That in Early Pregnancy1

Autor: Olivier W.H. van der Heijden, Marc E. A. Spaanderman, Guillaume J.J.M. van Eys, Louis L.H. Peeters, Jo G. R. De Mey, Yvonne P. G. Essers

Publikováno v: Biology of Reproduction. 73:1289-1293

During pregnancy, the lumenal diameter and wall mass of the uterine artery (UA) increase, most likely in response to the increased hemodynamic strain resulting from the chronically elevated uterine blood flow (UBF). In this remodeling process, the ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cb63d1d61c1b577a504cb20301ebe40
https://doi.org/10.1095/biolreprod.105.044438