Structural and functional fine mapping of cysteines in mammalian glutaredoxin reveal their differential oxidation susceptibility

Autor: Elizabeth M. Corteselli, Mona Sharafi, Robert Hondal, Maximilian MacPherson, Sheryl White, Ying-Wai Lam, Clarissa Gold, Allison M. Manuel, Albert van der Vliet, Severin T. Schneebeli, Vikas Anathy, Jianing Li, Yvonne M. W. Janssen-Heininger

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Protein-S-glutathionylation is a post-translational modification involving the conjugation of glutathione to protein thiols, which can modulate the activity and structure of key cellular proteins. Glutaredoxins (GLRX) are oxidoreductases tha

Externí odkaz: https://doaj.org/article/b5c9d223376f4a1cb9e9e02ac6e0d59e

Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models.

Autor: Jos L van der Velden, John F Alcorn, David G Chapman, Lennart K A Lundblad, Charles G Irvin, Roger J Davis, Kelly Butnor, Yvonne M W Janssen-Heininger

Publikováno v: PLoS ONE, Vol 15, Iss 1, p e0226904 (2020)

The stress-induced kinase, c-Jun-N-terminal kinase 1 (JNK1) has previously been implicated in the pathogenesis of lung fibrosis. However, the exact cell type(s) wherein JNK1 exerts its pro-fibrotic role(s) remained enigmatic. Herein we demonstrate pr

Externí odkaz: https://doaj.org/article/f8d307a682104fc8880e8ee9ed1135fb

Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Autor: Christopher M. Dustin, Nirav Daphtary, Caspar Schiffers, Lennart K. A. Lundblad, Niki L. Reynaert, Emiel F.M. Wouters, Albert van der Vliet, Minara Aliyeva, David J. Seward, Milena Hristova, Yvonne M. W. Janssen-Heininger, Aida Habibovic

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L144-L158. American Physiological Society
Am J Physiol Lung Cell Mol Physiol

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7b682d676a388c62b278898341509c
https://doi.org/10.1152/ajplung.00021.2021

Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases

Autor: Yvonne M. W. Janssen-Heininger, Jos van der Velden, Evan Elko, Ying-Wai Lam, Cheryl van de Wetering, Reem Aboushousha, Charles G. Irvin, Albert van der Vliet, David J. Seward, Shi B. Chia, Joseph E Druso, Vikas Anathy, Allison M. Manuel

Publikováno v: American Journal of Physiology-Cell Physiology. 318:C304-C327

Glutathione is a major redox buffer, reaching millimolar concentrations within cells and high micromolar concentrations in airways. While glutathione has been traditionally known as an antioxidant defense mechanism that protects the lung tissue from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1125f4e2ea35174b620428b13d8379be
https://doi.org/10.1152/ajpcell.00410.2019

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

Autor: Charles G. Irvin, Colin J. Henderson, C. Roland Wolf, Maximilian B. MacPherson, Ian M. Adcock, Angelo D'Alessandro, Reem Aboushousha, Mona Sharafi, Garrett Chan, Lennart K. A. Lundblad, Allison M. Manuel, Yvonne M. W. Janssen-Heininger, Florence Schleich, Nazanin Zounemat-Kermani, Emiel F.M. Wouters, Eric Bohrnsen, Matthew E. Poynter, Cheryl van de Wetering, Niki L. Reynaert, Albert van der Vliet, Cuixia Erickson, Jos van der Velden, Anne E. Dixon, Jianing Li, Xi Qian, Renaud Louis

Publikováno v: Redox Biology, Vol 47, Iss, Pp 102160-(2021)
Redox Biology
Redox Biology, 47:102160. Elsevier Science

Background Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430c10ff8ca1a0d7d330562da4bb2e87
http://www.sciencedirect.com/science/article/pii/S2213231721003207