Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yvonne M Kershaw"'
Autor:
Benjamin P Flynn, Matthew T Birnie, Yvonne M Kershaw, Audrys G Pauza, Sohyoung Kim, Songjoon Baek, Mark F Rogers, Alex R Paterson, Diana A Stavreva, David Murphy, Gordon L Hager, Stafford L Lightman, Becky L Conway-Campbell
Publikováno v:
PLoS Genetics, Vol 17, Iss 8, p e1009737 (2021)
Ultradian glucocorticoid rhythms are highly conserved across mammalian species, however, their functional significance is not yet fully understood. Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynam
Externí odkaz:
https://doaj.org/article/ebb7253002144d5885d6bce3701f46a0
Autor:
John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0227520 (2020)
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticoste
Externí odkaz:
https://doaj.org/article/11c2522dd7dd458c928d75377d179719
Autor:
Mitsuhiro Yoshimura, Benjamin P. Flynn, Yvonne M. Kershaw, Zidong Zhao, Yoichi Ueta, Stafford L. Lightman, Becky L. Conway-Campbell
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon most commonly associated with shift-work and transmeridian trave
Externí odkaz:
https://doaj.org/article/bcadd1670f5c46de9d4df0ba63659c00
Autor:
Matthew T. Birnie, Matthew D. B. Claydon, Oliver Troy, Benjamin P. Flynn, Mitsuhiro Yoshimura, Yvonne M. Kershaw, Zidong Zhao, Rebecca C. R. Demski-Allen, Gareth R. I. Barker, E. Clea Warburton, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway-Campbell
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Disrupted circadian activity is associated with many neuropsychiatric disorders. A major coordinator of circadian biological systems is adrenal glucocorticoid secretion which exhibits a pronounced preawakening peak that regulates metabolic, immune, a
Autor:
Matthew T. Birnie, Alen V. Eapen, Yvonne M. Kershaw, David Lodge, Graham L. Collingridge, Becky L. Conway‐Campbell, Stafford L. Lightman
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 34(10)
Over 50% of depressed patients show hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Conventional therapy takes weeks to months to improve symptoms. Ketamine has rapid onset antidepressant effects. Yet its action on HPA axis activity i
Autor:
Matthew T. Birnie, Matthew D.B. Claydon, Benjamin P. Flynn, Mitsuhiro Yoshimura, Yvonne M. Kershaw, Rebecca C.R. Demski-Allen, Gareth R.I. Barker, E. Clea Warburton, Zuner A. Bortolotto, Stafford L. Lightman, Becky L. Conway-Campbell
Neuropsychiatric disorders such as major depression and schizophrenia are highly prevalent and contribute substantially to disease burden worldwide. Despite this, progress understanding the pathophysiology has remained largely elusive, yet these diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6aba9fffa08156304733ee8ebb3d98
https://doi.org/10.1101/2022.07.12.499774
https://doi.org/10.1101/2022.07.12.499774
Autor:
Charlotte L, George, Matthew T, Birnie, Benjamin P, Flynn, Yvonne M, Kershaw, Stafford L, Lightman, Becky L, Conway-Campbell
Publikováno v:
Molecular and Cellular Endocrinology
In this paper we report differential decoding of the ultradian corticosterone signal by glucocorticoid target tissues. Pulsatile corticosterone replacement in adrenalectomised rats resulted in different dynamics of Sgk1 mRNA production, with a distin
Autor:
Helen C. Atkinson, James D. Leggett, Susan A. Wood, Emma S. Castrique, Yvonne M. Kershaw, Stafford L. Lightman
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:3561-3561