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Akademický článek

4335 Role of PSD95 and nNOS interaction in gene regulation following fear conditioning and implications for molecular mechanisms underlying PTSD

Autor: Jheel Patel, Erik Dustrude, Melissa Haulcomb, Liangping Li, Guanglong Jiang, Yunlong Liu, Yvonne Lai, Andrei Molosh, Anantha Shekhar

Publikováno v: Journal of Clinical and Translational Science, Vol 4, Pp 15-16 (2020)

OBJECTIVES/GOALS: Normal fear learning produces avoidance behavior that promotes survival, but excessive and persistent fear after trauma can lead to development of phobias and post-traumatic stress disorder (PTSD). Our goal is to understand the mech

Externí odkaz: https://doaj.org/article/3eaf9fa8e96b459891f4922e39ce21ae

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Akademický článek

77822 PSD95-nNOS interaction alters the basolateral amygdala transcriptome following fear conditioning: implications for molecular mechanisms underlying PTSD

Autor: Jheel Patel, Melissa Haulcomb, Liangping Li, Guanglong Jiang, Erik Dustrude, Yunlong Liu, Yvonne Lai, Andrei Molosh, Anantha Shekhar

Publikováno v: Journal of Clinical and Translational Science, Vol 5, Pp 23-23 (2021)

ABSTRACT IMPACT: This research takes a transcriptomic approach to parse genes and molecular pathways that underlie the fear memory circuitry and, in doing so, identifies therapeutic targets that can further be developed into treatments for fear disor

Externí odkaz: https://doaj.org/article/9ad7ab8c0dae43bcbb51b2c3c891b910

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Akademický článek

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.

Autor: Yvonne Lai, Guanghui Yi, Alice Chen, Kanchan Bhardwaj, Brady J Tragesser, Rodrigo A Valverde, Adam Zlotnick, Suchetana Mukhopadhyay, C T Ranjith-Kumar, C Cheng Kao

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25837 (2011)

Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor ag

Externí odkaz: https://doaj.org/article/5f68fb6114f049728ebe21c4cd9f312e

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Akademický článek

LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs.

Autor: Yvonne Lai, Sreedevi Adhikarakunnathu, Kanchan Bhardwaj, C T Ranjith-Kumar, Yahong Wen, Jarrat L Jordan, Linda H Wu, Bogdan Dragnea, Lani San Mateo, C Cheng Kao

Publikováno v: PLoS ONE, Vol 6, Iss 10, p e26632 (2011)

BACKGROUND:Toll-like Receptor 3 (TLR3) detects viral dsRNA during viral infection. However, most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to hypothesize that TLR3 needs additional factors to be activated by v

Externí odkaz: https://doaj.org/article/c818087142964be6bc051c5564cac815

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Akademický článek

Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I.

Autor: C T Ranjith-Kumar, Yvonne Lai, Robert T Sarisky, C Cheng Kao

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12878 (2010)

The Innate immune system constitutes the first line of defense against pathogen infections. The Retinoic acid-inducible gene I (RIG-I) receptor recognizes triphosphorylated ssRNAs and dsRNA to initiate downstream signaling of interferon response. How

Externí odkaz: https://doaj.org/article/c6fb74281cfe416fb000f9707a456ad3

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