Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Yvonne J K, Edwards"'
Autor:
Kiran Kumar Reddi, Suresh Chava, Siva Chander Chabattula, Yvonne J. K. Edwards, Kamaljeet Singh, Romi Gupta
Publikováno v:
Cell Death and Disease, Vol 15, Iss 6, Pp 1-17 (2024)
Abstract Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is prone to metastasis and therapy resistance. Owing to its aggressive nature and limited availability of targeted therapies, TNBC is associated with higher mortality as
Externí odkaz:
https://doaj.org/article/7574e4873e944cacab157790c41ee73a
Autor:
Shah S. Hussain, Yvonne J. K. Edwards, Emily Falk Libby, Denise Stanford, Stephen A. Byzek, Don D. Sin, Merry-Lynn McDonald, S. Vamsee Raju, Steven M. Rowe
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Chronic obstructive pulmonary disease (COPD) is a progressive lung disease with poor treatment options. However, most mouse models of COPD produce a primarily emphysematous disease not recapitulating clinically meaningful COPD fea
Externí odkaz:
https://doaj.org/article/5546bf39b4744faea935782b19592074
Publikováno v:
Oncogenesis, Vol 10, Iss 7, Pp 1-14 (2021)
ABSTRACT Ovarian cancer is the leading cause of gynecological malignancy-related deaths. Current therapies for ovarian cancer do not provide meaningful and sustainable clinical benefits, highlighting the need for new therapies. We show that the histo
Externí odkaz:
https://doaj.org/article/23c150ebe4db4cd3bdf5f05586a50b96
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Metastatic and drug-resistant melanoma are leading causes of skin cancer–associated death. Mitogen-associated protein kinase (MAPK) pathway inhibitors and immunotherapies have provided substantial benefits to patients with melanoma. However, long-t
Externí odkaz:
https://doaj.org/article/20d47083c6a9489ebdf7ee1df05b646f
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Although epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFRi) are approved for treating EGFR-mutant lung adenocarcinoma (LUAD), emergence of acquired resistance limits their clinical benefits. Several mechanisms for acquired res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb8ae7134973c5638eaa6b784726acb5
https://doi.org/10.1073/pnas.2218118120
https://doi.org/10.1073/pnas.2218118120
Autor:
Timothy P. Fitzgibbons, Yvonne J. K. Edwards, Peter Shaw, Aline Iskandar, Mohamed Ahmed, Josiah Bote, Tejen Shah, Sumita Sinha, Robert E. Gerszten, John F. Keaney, Michael R. Zile, Gerard P. Aurigemma
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 4 (2017)
Stress cardiomyopathy (SCM) is a unique cardiac disorder that more often occurs in women. SCM presents in a similar fashion as acute myocardial infarction (AMI), with chest pain, ECG changes, and congestive heart failure. The primary distinguishing f
Externí odkaz:
https://doaj.org/article/a15e7ab6bfa540f29216a848febf4001
Autor:
Santiago Vernia, Alexandra Lee, Norman J. Kennedy, Myoung Sook Han, Marta Isasa, Julie Cavanagh-Kyros, Armanda Roy, Aafreen Syed, Shanzah Chaudhry, Yvonne J. K. Edwards, Steven P. Gygi, Guangping Gao, Roger J. Davis
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(44)
The cJun NH2-terminal kinase (JNK) signaling pathway in the liver promotes systemic changes in metabolism by regulating peroxisome proliferator-activated receptor α (PPARα)-dependent expression of the hepatokine fibroblast growth factor 21 (FGF21).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124e10d85f30cfe06f2159bf45d25a62
https://pubmed.ncbi.nlm.nih.gov/36282921
https://pubmed.ncbi.nlm.nih.gov/36282921
Autor:
Roshan Dutta, Praveen Guruvaiah, Kiran Kumar Reddi, Suresh Bugide, Dhana Sekhar Reddy Bandi, Yvonne J K Edwards, Kamaljeet Singh, Romi Gupta
Publikováno v:
NAR Cancer. 4
Breast cancer is a leading cause of cancer-related deaths among women, and current therapies benefit only a subset of these patients. Here, we show that ubiquitin-conjugating enzyme E2T (UBE2T) is overexpressed in patient-derived breast cancer sample
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5bfc1e59befa5dad0543e3af6c7c20f
https://doi.org/10.1093/narcan/zcac035
https://doi.org/10.1093/narcan/zcac035
Publikováno v:
Am J Physiol Cell Physiol
The endoplasmic reticulum protein Jagunal (JAGN1) was first identified as a requirement for Drosophila melanogaster oocyte development. Subsequent studies in human patients linked mutations in JAGN1 to severe congenital neutropenia, as well as a broa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d12bf4a538c8677150885e94ace1de1
https://doi.org/10.1152/ajpcell.00436.2019
https://doi.org/10.1152/ajpcell.00436.2019
Autor:
Chad M. Petit, Andrew M. Clarke, David A. Schneider, Yvonne J. K. Edwards, Abigail K. Huffines
Publikováno v:
Genes; Volume 12; Issue 12; Pages: 1939
Genes, Vol 12, Iss 1939, p 1939 (2021)
Genes
Genes, Vol 12, Iss 1939, p 1939 (2021)
Genes
Saccharomyces cerevisiae has approximately 200 copies of the 35S rDNA gene, arranged tandemly on chromosome XII. This gene is transcribed by RNA polymerase I (Pol I) and the 35S rRNA transcript is processed to produce three of the four rRNAs required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827e818c15b2900f6b95d433f3244358