Výsledky vyhledávání - "Yvonne Ibig-Rehm"

Identification of Small Molecules Which Induce Skeletal Muscle Differentiation in Embryonic Stem Cells via Activation of the Wnt and Inhibition of Smad2/3 and Sonic Hedgehog Pathways

Autor: Maude Patoor, Corinne Haller, Yvonne Ibig‐Rehm, Shola M. Richards, Carole Manneville, Matthias Mueller, Caroline Gubser Keller, Thierry Doll, Marjo Goette, Isabelle Fruh, Hyun-Woo Lee, Laure C. Bouchez

Publikováno v: Stem Cells. 34:299-310

The multilineage differentiation capacity of mouse and human embryonic stem (ES) cells offers a testing platform for small molecules that mediate mammalian lineage determination and cellular specialization. Here we report the identification of two sm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4e20d7dbd06b1f5eea261821397966
https://doi.org/10.1002/stem.2228

Zobrazit plný text záznamu

Identification of SPPL2a Inhibitors by Multiparametric Analysis of a High-Content Ultra-High-Throughput Screen

Autor: Marjo Götte, Danilo Guerini, Ansgar Schuffenhauer, Daniela Siebert, Marion Kamke, Ursula Bodendorf, Yvonne Ibig-Rehm, Daniela Gabriel, Xian Zhang, Dan Beisner, Ghislain M. C. Bonamy

Publikováno v: SLAS discovery : advancing life sciences RD. 22(9)

The intramembrane protease signal peptide peptidase-like 2a (SPPL2a) is a potential drug target for the treatment of autoimmune diseases due to an essential role in B cells and dendritic cells. To screen a library of 1.4 million compounds for inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612b52645289838ac486f1b08e55e349
https://pubmed.ncbi.nlm.nih.gov/28731783

Zobrazit plný text záznamu

High-Content Assay to Study Protein Prenylation

Autor: Yvonne Ibig-Rehm, Gabriele Hofmann, Maxime Magnier, Johann Zimmermann, Marjo Simonen, Daniela Gabriel, Geneviève Albrecht, Valerie Heidinger

Publikováno v: SLAS Discovery. 13:456-467

The mevalonate pathway leads to synthesis of cholesterol and isoprenoid lipids. Prenyltransferases attach the isoprenoid lipids to the C-terminus of several small guanosine triphosphate–binding proteins. The prenyl groups are essential for the biol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af4b9bcff2efa54b4344676d598dcda
https://doi.org/10.1177/1087057108318757

Zobrazit plný text záznamu

Differentiation and visualization of diverse cellular phenotypic responses in primary high-content screening

Autor: Daniela Gabriel, Paul Selzer, Isabel Schmidt, Marjo Götte, Yvonne Ibig-Rehm, Anne Kümmel, Daniela Siebert, Jürgen Reinhardt, Christian N. Parker

Publikováno v: Journal of biomolecular screening. 17(6)

High-throughput screening, based on subcellular imaging, has become a powerful tool in lead discovery. Through the generation of high-quality images, not only the specific target signal can be analyzed but also phenotypic changes of the whole cell ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebac44dd79c00e522dbc41c2c3d11d43
https://pubmed.ncbi.nlm.nih.gov/22396475

Zobrazit plný text záznamu

High-content screening to distinguish between attachment and post-attachment steps of human cytomegalovirus entry into fibroblasts and epithelial cells

Autor: David Woodhall, Adam L. Feire, Marjo Götte, Yvonne Ibig-Rehm, Teresa Compton, Nathan Brown, Daniela Gabriel, Ashley Shea

Publikováno v: Antiviral research. 89(3)

Human cytomegalovirus (HCMV) enters cells through a complex pathway involving the interaction of multiple viral glycoproteins and cellular receptors. While HCMV clinical isolates enter a wide range of cell types, entry has historically been studied u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396b1a8023cfbb270849b5767c0f9be9
https://pubmed.ncbi.nlm.nih.gov/21277329

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání