Výsledky vyhledávání - "Yvonne Eyobo"

Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement

Autor: Leonardo Sorci, Alexander D. MacKerell, Hong Zhang, Andrei L. Osterman, Nian Huang, Irina A. Rodionova, Rohit Kolhatkar, Yvonne Eyobo

Publikováno v: Journal of Medicinal Chemistry. 53:5229-5239

Bacterial nicotinate mononucleotide adenylyltransferase encoded by the essential gene nadD plays a central role in the synthesis of the redox cofactor NAD(+). The NadD enzyme is conserved in the majority of bacterial species and has been recognized a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794f0c22441659045c906b25001985ce
https://doi.org/10.1021/jm100377f

Zobrazit plný text záznamu

Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis

Autor: Xhavit Zogaj, Yvonne Eyobo, Hong Zhang, Giulio Magni, Evgeni V. Nikolaev, Dmitry A. Rodionov, Dariusz Martynowski, Andrei L. Osterman, Leonardo Sorci, Karl E. Klose

Publikováno v: Proceedings of the National Academy of Sciences. 106:3083-3088

Enzymes involved in the last 2 steps of nicotinamide adenine dinucleotide (NAD) cofactor biosynthesis, which catalyze the adenylylation of the nicotinic acid mononucleotide (NaMN) precursor to nicotinic acid dinucleotide (NaAD) followed by its amidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a527623e900722983cdf3bd23958676
https://doi.org/10.1073/pnas.0811718106

Zobrazit plný text záznamu

Crystal Structure of α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase: Insight into the Active Site and Catalytic Mechanism of a Novel Decarboxylation Reaction

Autor: Tingfeng Li, Kun Yang, Yvonne Eyobo, Hong Zhang, Dariusz Martynowski, Aimin Liu

Publikováno v: Biochemistry. 45:10412-10421

Alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD) is a widespread enzyme found in many bacterial species and all currently sequenced eukaryotic organisms. It occupies a key position at the branching point of two metabolic pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9309f852ec8fa84001dbdcd5b2851c39
https://doi.org/10.1021/bi060903q

Zobrazit plný text záznamu

Yersinia Effector YopJ Inhibits Yeast MAPK Signaling Pathways by an Evolutionarily Conserved Mechanism

Autor: Zhengchang Liu, Yvonne Eyobo, Kim Orth, Sara Yoon

Publikováno v: Journal of Biological Chemistry. 278:2131-2135

Yersinia effector, YopJ, inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways in mammalian cells. Herein, YopJ is shown to disrupt the MAP kinase signaling pathways in Saccharomyces cerevisiae. Expression of YopJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f8264b7833ffa3f1359998ca81d769
https://doi.org/10.1074/jbc.m209905200

Zobrazit plný text záznamu

Trinuclear silver(I) complexes of fluorinated pyrazolates

Autor: Nathan Roehr, Ivan Omari, Chammi S. Palehepitiya Gamage, Nadeeka R Dias, Himashinie V. K. Diyabalanage, Yvonne Eyobo, H. V. Rasika Dias, Lesly McKinney, Theresa Poth, Jeremy Keltner

Publikováno v: Inorganic chemistry. 46(8)

Silver pyrazolates [[3-(CF3)Pz]Ag]3, [[3-(CF3),5-(CH3)Pz]Ag]3, [[3-(CF3),5-(Ph)Pz]Ag]3, [[3-(CF3),5-(But)Pz]Ag]3, and [[3-(C3F7),5-(But)Pz]Ag]3 have been synthesized by treatment of the corresponding pyrazole with a slight molar excess of silver(I) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5634a000254f96e1cd72a2942a6c86
https://pubmed.ncbi.nlm.nih.gov/17375913

Zobrazit plný text záznamu

Crystal Structure of a Type III Pantothenate Kinase: Insight into the Mechanism of an Essential Coenzyme A Biosynthetic Enzyme Universally Distributed in Bacteria†

Autor: Diana R. Tomchick, Leisl A. Brand, Hong Zhang, Dariusz Martynowski, Yvonne Eyobo, Erick Strauss, Kun Yang

Pantothenate kinase (PanK) catalyzes the first step in the five-step universal pathway of coenzyme A (CoA) biosynthesis, a key transformation that generally also regulates the intracellular concentration of CoA through feedback inhibition. A novel Pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37a0d5517272851b312ea2deec7614
https://europepmc.org/articles/PMC1540032/

Zobrazit plný text záznamu

Akademický článek

Complexes of Bacterial Nicotinate Mononucleotide Adenylyltransferase with Inhibitors: Implication for Structure-Based Drug Design and Improvement.

Autor: Nian Huang, Rohit Kolhatkar, Yvonne Eyobo, Leonardo Sorci, Irina Rodionova, Andrei L. Osterman, Alexander D. MacKerell, Hong Zhang

Publikováno v: Journal of Medicinal Chemistry; Jul2010, Vol. 53 Issue 14, p5229-5239, 11p

Zobrazit plný text záznamu

Targeting NAD Biosynthesis in Bacterial Pathogens: Structure-Based Development of Inhibitors of Nicotinate Mononucleotide Adenylyltransferase NadD

Autor: Yvonne Eyobo, Yongping Pan, Leonardo Sorci, Oleg V. Kurnasov, Nian Huang, Irina A. Rodionova, Alexander D. MacKerell, Andrei L. Osterman, Shijun Zhong, Hong Zhang

Publikováno v: Chemistry & Biology. (8):849-861

SummaryThe emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fb0e202189c5035686c3863a182d0f

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání