Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Yvonne Eskildsen-Helmond"'
Autor:
Michael R. Horsman, Britt Elmedal Laursen, Ulf Simonsen, Junjing Su, Yvonne Eskildsen-Helmond
Publikováno v:
Su, J, Laursen, B E, Eskildsen-Helmond, Y, Horsman, M R & Simonsen, U 2012, ' The vascular-disrupting agent, combretastatin-A4-phosphate, enhances neurogenic vasoconstriction in rat small arteries ', European Journal of Pharmacology, pp. 104-111 . https://doi.org/10.1016/j.ejphar.2012.08.023
Combretastatin-A4-phosphate (CA4P/CA4), an anti-cancer drug, induces tumour hypoxia by destabilizing the cytoskeleton in tumour endothelial cells. Hypertensive side effects have been observed. We hypothesized that CA4P/CA4 lead to endothelial dysfunc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa1852350e97cd6111ea1ec619afd0f
https://doi.org/10.1016/j.ejphar.2012.08.023
https://doi.org/10.1016/j.ejphar.2012.08.023
Autor:
Britt Elmedal Laursen, Henrik Vorum, Bent Honoré, Michael J. Mulvany, Ulf Simonsen, Jonas Baandrup, Lise Bech Thorsen, Louise Østergaard, Yvonne Eskildsen-Helmond
Publikováno v:
Østergaard, L, Honoré, B, Thorsen, L B, Baandrup, J, Eskildsen-Helmond, Y, Laursen, B E, Vorum, H, Mulvany, M J & Simonsen, U 2011, ' Pulmonary pressure reduction attenuates expression of proteins identified by lung proteomic profiling in pulmonary hypertensive rats ', Proteomics, vol. 11, no. 23, pp. 4492-502 . https://doi.org/10.1002/pmic.201100171
The present study was designed to analyze protein expression in lungs from pulmonary hypertensive rats in order to identify novel signaling pathways. This was achieved by proteomic studies in which proteins from lung homogenates from hypoxic were com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d62e192da0f74485018fbc018f2cad
https://doi.org/10.1002/pmic.201100171
https://doi.org/10.1002/pmic.201100171
Autor:
Yvonne Eskildsen-Helmond, Khalid Matrougui, Michael J. Mulvany, Alain Tedgui, Bernard I. Levy, Daniel Henrion, A. Fiebeler
Publikováno v:
Matrougui, K, Eskildsen-Helmond, Y, Fiebeler, A, Henrion, D, Levy, B I, Tedgui, A & Mulvany, M J 2000, ' Angiotensin II stimulates extracellular signal-regulated kinase activity in intact pressurized rat mesenteric resistance arteries. ', Hypertension, vol. 36, no. 4, pp. 617-621 .
Aarhus University
Aarhus University
Abstract —The activation of extracellular signal–regulated kinases 1/2 (ERK1/2) was assessed in isolated rat mesenteric resistance arteries (200-μm diameter) in a pressure myograph and stimulated for 5 minutes by angiotensin II (Ang II, 0.1 μmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a97c1e2996cdf9c49049342ec73511
https://doi.org/10.1161/01.hyp.36.4.617
https://doi.org/10.1161/01.hyp.36.4.617
Autor:
Yvonne Eskildsen-Helmond, Lise Bech Thorsen, Britt Elmedal Laursen, Johannes-Peter Stasch, Helle Zibrandtsen, Ulf Simonsen
Publikováno v:
Thorsen, L, Eskildsen-Helmond, Y, Zibrandtsen, H, Stasch, J-P, Simonsen, U & B., E L 2010, ' BAY 41-2272 inhibits the development of chronic hypoxic pulmonary hypertension in rats ', European Journal of Pharmacology, vol. 647, no. 1-3, pp. 147-54 .
The present study investigated whether BAY 41-2272(5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine), a novel pyrazolopyridine that activates guanylyl cyclase and sensitizes the enzyme towards nitric oxide (NO)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f17c1f932f414aadf99f0fed32d2515
https://pubmed.ncbi.nlm.nih.gov/20828552
https://pubmed.ncbi.nlm.nih.gov/20828552
Autor:
Michael J. Mulvany, Niels Uldbjerg, Henrik Vorum, Ulf Simonsen, Bent Honoré, Louise Østergaard, Yvonne Eskildsen-Helmond
Publikováno v:
Østergaard, L, Simonsen, U, Eskildsen-Helmond, Y, Vorum, H, Uldbjerg, N, Honoré, B & Mulvany, M J 2009, ' Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells. ', Proteomics, vol. 9, no. 19, pp. 4457-67 .
Aarhus University
Ostergaard, L, Simonsen, U, Eskildsen-Helmond, Y, Vorum, H, Uldbjerg, N, Honoré, B & Mulvany, M J 2009, ' Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells ', Proteomics, vol. 9, no. 19, pp. 4457-67 . https://doi.org/10.1002/pmic.200800130
Aarhus University
Ostergaard, L, Simonsen, U, Eskildsen-Helmond, Y, Vorum, H, Uldbjerg, N, Honoré, B & Mulvany, M J 2009, ' Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells ', Proteomics, vol. 9, no. 19, pp. 4457-67 . https://doi.org/10.1002/pmic.200800130
A proteomic approach was applied to explore the signalling pathways elicited by lowering O(2) in endothelial cells. Endothelial cells isolated from native umbilical cords were subjected to 21, 5, or 1% O(2) for 24 h. 2-D PAGE was performed and candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d20b2438cd8eee2f92c3695fc6a5b5d
https://pure.au.dk/portal/da/publications/proteomics-reveals-lowering-oxygen-alters-cytoskeletal-and-endoplasmatic-stress-proteins-in-human-endothelial-cells(5a6ba180-a77c-11de-a554-000ea68e967b).html
https://pure.au.dk/portal/da/publications/proteomics-reveals-lowering-oxygen-alters-cytoskeletal-and-endoplasmatic-stress-proteins-in-human-endothelial-cells(5a6ba180-a77c-11de-a554-000ea68e967b).html
Autor:
Malene Rohr Andersen, Edgaras Stankevičius, Ulf Simonsen, Yvonne Eskildsen-Helmond, Thomas Ledet, Louise Østergaard, Michael J. Mulvany
Publikováno v:
Østergaard, L, E., S, Andersen, M R, Eskildsen-Helmond, Y, Ledet, T, Mulvany, M J & Simonsen, U 2007, ' Diminished NO release in chronic hypoxic human endothelial cells ', Am. J. Physiol. Heart Circ Physiol, vol. 293(5), pp. H2894-903 .
Aarhus University
Aarhus University
The present study addressed whether chronic hypoxia is associated with reduced nitric oxide (NO) release due to decreased activation of endothelial NO synthase (eNOS). Primary cultures of endothelial cells from human umbilical veins (HUVECs) were use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f83618443c337a077b565f053b0459b
https://pubmed.ncbi.nlm.nih.gov/17720765
https://pubmed.ncbi.nlm.nih.gov/17720765
Publikováno v:
Nielsen, E R, Eskildsen-Helmond, Y E G & Rattan, S I S 2006, ' MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro ', New York Academy of Sciences. Annals, vol. 1067, pp. 343-348 . https://doi.org/10.1196/annals.1354.048
Adult human skin fibroblasts were exposed repeatedly to 41 degrees C or 42 degrees C heat shock (HS) for 1 h twice a week during serial passaging throughout their replicative life span. On the basis of longevity curves, cell size, and morphology, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6c4d9ffd995cf62f106e44f4316324
https://pubmed.ncbi.nlm.nih.gov/16804009
https://pubmed.ncbi.nlm.nih.gov/16804009
Publikováno v:
Rattan, S I S, Eskildsen-Helmond, Y E G & Beedholm, R 2004, ' Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells ', Dose-Response, vol. 2, no. 2, pp. 105-16 . https://doi.org/10.1080/15401420490464376
Rattan, S, Eskildsen-Helmond, Y & Beedholm, R 2004, ' Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells ', Nonlinearity, no. 2, pp. 1-12 .
Dose-Response, Vol 2 (2004)
Aarhus University
Rattan, S, Eskildsen-Helmond, Y & Beedholm, R 2004, ' Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells ', Nonlinearity, no. 2, pp. 1-12 .
Dose-Response, Vol 2 (2004)
Aarhus University
Udgivelsesdato: 2004-Apr In a series of experimental studies we have shown that repetitive mild heat stress has anti-aging hormetic effects on growth and various other cellular and biochemical characteristics of human skin fibroblasts undergoing agin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d73f6cae3568093b3a7e139763a9f6
https://pure.au.dk/portal/da/publications/molecular-mechanisms-of-antiaging-hormetic-effects-of-mild-heat-stress-on-human-cells(45514df0-81ba-11de-b4c2-000ea68e967b).html
https://pure.au.dk/portal/da/publications/molecular-mechanisms-of-antiaging-hormetic-effects-of-mild-heat-stress-on-human-cells(45514df0-81ba-11de-b4c2-000ea68e967b).html
Publikováno v:
Aarhus University
Extracellular signal-regulated kinase 1/2 (ERK1/2) may play a central signaling role in vascular remodeling. We investigated a possible combined role for the renin-angiotensin system and platelet-derived growth factor β-receptor (PDGF-β-R) in press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24cbbab3b9731391fbb7185185811f4c
https://pubmed.ncbi.nlm.nih.gov/12623863
https://pubmed.ncbi.nlm.nih.gov/12623863
Publikováno v:
Aarhus University
Rattan, S, Eskildsen-Helmond, Y & Beedholm, R 2004, ' Molecular mechanisms of anti-aging hormetic effects of mild stress on human cells. ', Dose-Response, vol. 2, no. 2, pp. 105-116 .
Rattan, S, Eskildsen-Helmond, Y & Beedholm, R 2004, ' Molecular mechanisms of anti-aging hormetic effects of mild stress on human cells. ', Dose-Response, vol. 2, no. 2, pp. 105-116 .
Udgivelsesdato: April-June
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ebeca4c7ba7f3ecb072dc6eccddcf65c
https://pure.au.dk/portal/en/publications/molecular-mechanisms-of-antiaging-hormetic-effects-of-mild-stress-on-human-cells(4a5f8480-aa24-11db-bee9-02004c4f4f50).html
https://pure.au.dk/portal/en/publications/molecular-mechanisms-of-antiaging-hormetic-effects-of-mild-stress-on-human-cells(4a5f8480-aa24-11db-bee9-02004c4f4f50).html