PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages – a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

Autor: Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E Koot, Ruth Bender Atik, Kitty WM Bloemenkamp, Rebecca Brady, Annette Briley, Rebecca Cavallaro, Ying C Cheong, Justin Chu, Abey Eapen, Holly Essex, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Steve Parrott, Jackie A Ross, Lisa Sharpe, Jane Stewart, Dominic Trépel, Nirmala Vaithilingam, Roy G Farquharson, Mark David Kilby, Yacoub Khalaf, Mariëtte Goddijn, Lesley Regan, Rajendra Rai

Publikováno v: Health Technology Assessment, Vol 20, Iss 41 (2016)

Background and objectives: Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians and Gynaecologists and a Cochrane review called for a definitive trial to test whether or not progesterone therapy

Externí odkaz: https://doaj.org/article/c2c17247e8b7424c8d0a4e985677c1a1

A Randomized Trial of Progesterone in Women with Recurrent Miscarriages

Autor: Marjory MacLean, Feroza Dawood, Siobhan Quenby, Eugenie M. Kaaijk, Ayman Ewies, Carolien A.M. Koks, Ruth Bender Atik, Justin Chu, Tin-Chiu Li, Rebecca Brady, Arri Coomarasamy, Ying Cheong, Annemieke Hoek, Rajendra Rai, Ben W.J. Mol, Lisa Sharpe, Rachel Small, Roy G. Farquharson, Kitty W.M. Bloemenkamp, Yacoub Khalaf, Jane Stewart, Judith Moore, Nirmala Vaithilingam, Annette Briley, Abey Eapen, Mark D. Kilby, Mariëtte Goddijn, Paul T. Seed, Lesley Regan, Pratima Gupta, Ewa Truchanowicz, Yvonne E Koot, Rebecca Cavallaro, Helen M Williams, Jackie Ross

Publikováno v: New England Journal of Medicine, 373(22), 2141. Massachussetts Medical Society
New England journal of medicine, 373(22), 2141-2148. Massachussetts Medical Society
Coomarasamy, A, Williams, H, Truchanowicz, E, Seed, P T, Small, R, Quenby, S, Gupta, P, Dawood, F, Koot, Y E M, Bender Atik, R, Bloemenkamp, K W M, Brady, R, Briley, A L, Cavallaro, R, Cheong, Y C, Chu, J J, Eapen, A, Ewies, A, Hoek, A, Kaaijk, E M, Koks, C A M, Li, T-C, MacLean, M, Mol, B W, Moore, J, Ross, J A, Sharpe, L, Stewart, J, Vaithilingam, N, Farquharson, R G, Kilby, M D, Khalaf, Y, Goddijn, M, Regan, L & Rai, R 2015, ' A Randomized Trial of Progesterone in Women with Recurrent Miscarriages ', New England Journal of Medicine, vol. 373, no. 22, pp. 2141-8 . https://doi.org/10.1056/NEJMoa1504927
New England Journal of Medicine, 373(22), 2141-2148
New England Journal of Medicine, 373(22), 2141-2148. MASSACHUSETTS MEDICAL SOC

BACKGROUND: Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in the first trimester of pregnancy would increase the rate of live births among women with a history of unexplained recurrent misca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73e6d4a9f51e94f1fdaa9524b02135a
https://doi.org/10.1056/nejmoa1504927

PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages – a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

Autor: Eugenie M. Kaaijk, Siobhan Quenby, Judith Moore, Pratima Gupta, Nirmala Vaithilingam, Holly Essex, Rachel Small, Annette Briley, Helen Williams, Marjory MacLean, Feroza Dawood, Arri Coomarasamy, Yacoub Khalaf, Dominic Trépel, Ben W.J. Mol, Justin Chu, Carolien A.M. Koks, Mariëtte Goddijn, Mark D. Kilby, Ewa Truchanowicz, Annemieke Hoek, Rajendra Rai, Rebecca Brady, Rebecca Cavallaro, Ayman Ewies, Paul T. Seed, Jackie Ross, Abey Eapen, Yvonne E Koot, Steve Parrott, Tin-Chiu Li, Ruth Bender Atik, Jane Stewart, Lisa Sharpe, Kitty W.M. Bloemenkamp, Lesley Regan, Ying Cheong, Roy G. Farquharson

Publikováno v: Health Technology Assessment, Vol 20, Iss 41 (2016)
Health Technology Assessment, 20(41), 1-+. NIHR JOURNALS LIBRARY
Coomarasamy, A, Williams, H, Truchanowicz, E, Seed, P T, Small, R, Quenby, S, Gupta, P, Dawood, F, Koot, Y E, Atik, R B, Bloemenkamp, K W, Brady, R, Briley, A, Cavallaro, R, Cheong, Y C, Chu, J, Eapen, A, Essex, H, Ewies, A, Hoek, A, Kaaijk, E M, Koks, C A, Li, T-C, MacLean, M, Mol, B W, Moore, J, Parrott, S, Ross, J A, Sharpe, L, Stewart, J, Trépel, D, Vaithilingam, N, Farquharson, R G, Kilby, M D, Khalaf, Y, Goddijn, M, Regan, L & Rai, R 2016, ' PROMISE : first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages-a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation ', Health technology assessment (Winchester, England), vol. 20, no. 41, pp. 1-92 . https://doi.org/10.3310/hta20410
Health technology assessment (Winchester, England), 20(41), 1-92. National Co-ordinating Centre for HTA
Health Technology Assessment, 20(41), 1. National Co-ordinating Centre for HTA

Background and objectivesProgesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians and Gynaecologists and a Cochrane review called for a definitive trial to test whether or not progesterone therapy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e23fb6283ef8313af2d78e02d4467ef
https://doaj.org/article/c2c17247e8b7424c8d0a4e985677c1a1

Recurrent pre-clinical pregnancy loss is unlikely to be a 'cause' of unexplained infertility

Autor: Nick S. Macklon, Carolien M. Boomsma, Yvonne E Koot, Marinus J.C. Eijkemans, Eef G.W.M. Lentjes

Publikováno v: Human Reproduction. 26:2636-2641

BACKGROUND A proportion of women with ‘unexplained’ infertility may present with subfertility because their pregnancies fail before they are clinically recognized. In order to test whether pre-clinical early pregnancy losses (EPL) occur more freq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27d18957e38d3ee67591f29c0c4d37c
https://doi.org/10.1093/humrep/der217

Molecular aspects of implantation failure

Autor: Gijs Teklenburg, Madhuri S. Salker, Yvonne E Koot, Nick S. Macklon, Jan J. Brosens

Publikováno v: Biochimica et biophysica acta. 1822(12)

Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::688e2d72d6f4dabc8e23dbd2dae0dea0
https://pubmed.ncbi.nlm.nih.gov/22683339